Comparison of the Effect of Two Different Types of HIIT on Serum Homocysteine and 25-hydroxyvitamin D Levels in Overweight Women with Low Vitamin D Status

Subject Areas : Journal of Chemical Health Risks

Ghanbar Ali Samadi ¹ , Saqqa Farajtabar Behrestaq ^{2 *} , Babisan Askari ³ , Ali Pourmahak ⁴ , seyedehfatemeh Jalali ⁵

1 - Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
2 - Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
3 - Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
4 - Department of Physical Education and Sport Sciences, Bandaranzali Branch, Islamic Azad University, Bandaranzali, Iran
5 - Master of Physical Education and Sports Sciences, Teacher of Physical Education in the 1st District of Sari, Iran

Received: 2024-04-29 Accepted : 2024-09-17 Published : 2025-04-19

Keywords: Overweight, High-intensity interval training, Homocysteine, Vitamin D,

Abstract :

Vitamin D deficiency along with obesity, which is a significant health problem, can increase the risk of many diseases. Regular exercise has a favorable effect on this problem, but some people spend little or no time to benefit from these favorable effects. In this study, the effect of two different types of high intensity interval training on serum homocysteine and 25-hydroxyvitamin D levels in overweight women with low vitamin D levels was compared. This semi-experimental study was conducted on 39 overweight women with vitamin D deficiency. Subjects were randomly divided into control groups, high intensity interval resistance training, and high intensity interval running training after being selected using the available sampling method. Interval training were performed during 8 weeks and 3 sessions per week. High intensity interval resistance training was performed in three sets with an intensity of 80% of a maximum repetition and a 2.5minute rest between sets. high intensity interval running training was performed with the 12 x 1-min running bouts at 80-90% HRmax interspersed with 1-min active recovery at 50% HRmax. Data were analyzed using one-way ANOVA tests (Kruskal-Wallis for non-normal data) and paired t at a significance level of less than P<0.05. After 8 weeks, the level of homocysteine in the experimental groups decreased and the level of 25-hydroxyvitamin D increased significantly (P<0.05). In addition, there was no significant difference between the effect of two types of intermittent exercise on reducing homocysteine or increasing 25-hydroxyvitamin D (P<0.05). It seems that both types of intense interval training (repetitive running and resistance) can have similar protective effects in obese women with vitamin D deficiency, by reducing homocysteine, improving vitamin D status, and reducing body weight.

References:

1. Alidarzi E., Askari B., Habibian M., 2023. Investigating the Effect of Two Models of High-Intensity Interval on Brain-Derived Neurotrophic Factor and Body Composition in Women with Vitamin D Deficiency. J Jiroft Univ Med Sci. 10(1), 1228-1237.
2. Ercan M., Konukoglu D., 2008. Role of plasma viscosity and plasma homocysteine level on hyperinsulinemic obese female subjects. Clin Hemorheol Microcirc. 38(4), 227-34.
3. Yoo TK., Rhim HC., Lee YT., 2022. Relationship between hyperhomocysteinemia and coexisting obesity with low skeletal muscle mass in asymptomatic adult population. Sci Rep. 12, 12439.
4. Glueck C.J., Jetty V., Rothschild M., Duhon G., Shah P., Prince M., Lee K., Goldenberg M., Kumar A., Goldenberg N., Wang P., 2016. Associations between serum 25-hydroxyvitamin D and lipids, lipoprotein cholesterols, and homocysteine. North Am J Med Sci. 8, 284-90
5. Pham T.M., Ekwaru J.P., Mastroeni S.S., Mastroeni M.F., Loehr S.A., Veugelers P.J., 2016. The Effect of Serum 25-Hydroxyvitamin D on Elevated Homocysteine Concentrations in Participants of a Preventive Health Program. PLoS One. 11(8), e0161368.
6. Amer M., Qayyum R., 2104. The relationship between 25-hydroxyvitamin D and homocysteine in asymptomatic adults. J Clin Endocrinol Metab. 99, 633–8.
7. Karimi M., rahnama M., 2018. Effect of 8 Weeks of Selected Pilates Exercises on Plasma Levels of Homocysteine and Fibrinogen in Non-Athlete Obese Women. Qom Univ Med Sci J. 11(11), 33-40
8. Tuttor M., von Stengel S., Kohl M., Lell M., Scharf M., Uder M., Wittke A., Kemmler W., 2018. High Intensity Resistance Exercise Training vs. High Intensity (Endurance) Interval Training to Fight Cardiometabolic Risk Factors in Overweight Men 30-50 Years Old. Front Sports Act Living. 2020(2), 68.
9. Rafiq S., Jeppesen P.B., 2018. Body mass index, vitamin D, and type 2 diabetes: A systematic review and meta-analysis. Nutrients. 10(9), E1182
10. Aghamohammadi A., Mogharnasi M., Kianian T., 2015. Effects of different types of exercise training and detraining on plasma homocysteine and the factors associated with obesity in sedentary young men. Der Pharmacia Lettre. 7(9), 78-83
11. Rao G., 2018. Cardiometabolic diseases: a global perspective. J. Cardiol. Cardiovasc. Ther. 12, 1–5. Gundu H R. Cardiometabolic Diseases: A Global Perspective. J Cardiol & Cardiovasc Ther. 12(2), 555834.
12. Hankey G.J., Eikelboom J.W., Ho W.K., van Bockxmeer F.M., 2004. Clinical usefulness of plasma homocysteine in vascular disease. Med J Aust. 20;181(6), 314-8.
13. Scott K., Edward T., 2019. Exercise Physiology: Theory and Application to Fitness and Performance Tenth Edition; McGraw-Hill Education: New York, NY, USA. pp.302–320
14. Barker T., Henriksen V.T., Martins T.B., Hill H.R., Kjeldsberg C.R., Schneider E.D., Dixon B.M., Weaver L.K., 2013. Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury. Nutrients. 17;5(4), 1253-75.
15. Sun X., Ma XK., Zhang L., Cao ZB., 2020. Effects of resistance training on serum 25(OH)D concentrations in young men: A randomized controlled trial. Nutr Metab. 17, 1–7.
16. Makanae Y., Ogasawara R., Sato K., Takamura Y., Matsutani K., Kido K., Shiozawa N., Nakazato K., Fujita S., 2015. Acute bout of resistance exercise increases vitamin D receptor protein expression in rat skeletal muscle. Exp Physiol. 100, 1168–76.
17. Vella CA., Taylor K., Drummer D., 2017. High-intensity interval and moderate-intensity continuous training elicit similar enjoyment and adherence levels in overweight and obese adults. Eur J Sport Sci. 17(9), 1203-1211.
18. Eslami Vasmaleii F., Habibian M., Moosavi S.J., 2021. The effectiveness of vitamin D supplementation with Pilates Training on vitamin D status in overweight men. A clinical trial study. Medical journal of mashhad university of medical sciences. 23(5), 17-28.
19. Abdeen H.A.A., Rodriguez-Sanz D., Ewidea M., Al-Hamaky D.M.A., Mohamed M.A.E., Elerian A.E., 2021. Efficacy of Vitamin D Supplementation in Addition to Aerobic Exercise Training in Obese Women with Perceived Myalgia: A Single-Blinded Randomized Controlled Clinical Trial. Nutrients. 27;13(6),1819.
20. Wang Y., Jiang Y., Wang N., Zhu M., Liu X., Wang R., Jiang F., Chen Y., Zhao Q., Zhao G., 2019. Central But Not General Obesity Is Positively Associated with the Risk of Hyperhomocysteinemia in Middle-Aged Women. Nutrients. 11(7),1614.
21. Xiang Y., Zhao Q., Wang N., Yu Y., Wang R., Zhang Y., Cui S., Wu Y., Liu X., Jiang Y., Yu Y., Zhao G., 2021. Association of Obesity with the Risk of Hyperhomocysteinemia among the Chinese Community Residents: A Prospective Cohort Study in Shanghai, China. Nutrients. 13, 3648.
22. Poon ET., Little JP., Sit CH., Wong SH., 2020. The effect of low-volume high-intensity interval training on cardiometabolic health and psychological responses in overweight/obese middle-aged men. J Sports Sci. 38(17),1997-2004.
23. Park S.B., Georgiades A., 2013. Changes in Body Composition Predict Homocysteine Changes and Hyperhomocysteinemia in Korea. J. Korean Med Sci. 28, 1015–1020.
24. Jafari M., Rahimzadeh S., Gharezadeh S., 2021. Effect of eight weeks High Intensity Interval Training (HIIT) on some atherogenic factors. EBNESINA. 23(3), 79-84.
25. Bahram M.E., Pourvaghar M.J., 2016. The Effect of 12 Weeks of High-Intensity Interval Training (HIIT) on Homocysteine and CRP Cardiovascular Risk Factors and Body Composition in Overweight Men. JABS. 6(3), 334-342.
26. Mohammadyari S., Abdi S., Bakhtiyari A., 2019. The effect of low volume high-intensity interval training on predictive markers of cardiovascular disease in overweight men', Sport Physiology & Management Investigations. 11(2),133-143.
27. Hjinajaf S., mohammadi F., Azizi M., 2018. Effect of Aerobic Interval Exercise Training on Serum Levels of 25-Hydroxyvitamin D and Indices Anthropometry in Overweight and Obesity Patients. Jundishapur Scientific Medical Journal. 17(1), 37-48.
28. Kobza V.M., Fleet J.C., Zhou J., Conley T.B., Peacock M., IglayReger H.B., DePalma G., Campbell W.W., 2013. Vitamin D status and resistance exercise training independently affect glucose tolerance in older adults. Nutr Res. 33, 349-57.
29. Xiang Y., Zhao Q., Wang N., Yu Y., Wang R., Zhang Y., Cui S., Wu Y., Liu X., Jiang Y., Yu Y., Zhao G., 2021. Association of Obesity with the Risk of Hyperhomocysteinemia among the Chinese Community Residents: A Prospective Cohort Study in Shanghai, China. Nutrients. 13, 3648.