Synthesis of New Glycine Cephalexin Condensed Polymer as Peptide Biopolymer for Controlled Release of Cephalexin
Subject Areas : Journal of Chemical Health Risks
Aseel K.Al-Saffar
1
(College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq)
Ahamed M. Abbas
2
(Department of Chemistry, College of Science, University of Misan, Maysan, Iraq)
Dawood Salman
3
(Department of Chemistry, College of Science, University of Misan, Maysan, Iraq)
Keywords: Characterization, glycine, Physical properties, Cephalexin, biopolymer,
Abstract :
A new peptide-based polymer was synthesized via polymerization of cephalexin acid chloride with glycine acid chloride with molar ratio 1:1 in condensed polymer solution. This Glycine Cephalexin peptide biopolymer was characterized by different analyses of UV, FT-IR and 1H NMR spectroscopy. Also, physical properties of new synthesized Glycine Cephalexin peptide biopolymer were studied with measurement of its intrinsic viscosity at 30°C, swelling percentage in water and studying drug release in pH 4-10 at 37°C.