The Study of the Effectiveness of a Mixture of Arnebia Euochroma and Gum Extract in Animal Oils and Comparing It with Honey in Diabetic Foot Ulcer
Subject Areas : Journal of Chemical Health RisksAli Sharifi 1 , Elham Shafiei 2 , Morteza Hoseinzadeh 3
1 - Department of Internal Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
2 - Clinical Research Development Unit, Mostafa Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran
3 - Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
Keywords: Honey, Diabetic Foot Ulcer, Arenbi Euro Chroma Plant, Gum Wax,
Abstract :
One of the most important causes of disability in diabetic patients is diabetic foot ulcers. Native use of medicinal herbs may significantly affect the wound healing process. In this study, a mixture of Arnebia euochroma extracts and essential oil of Pistacia Atlantica in animal oil used for healing diabetic wounds was compared with natural honey. Thirty male Wistar rats weighing 250 g became diabetic. Wounds of equal size were created in their back area and the wound was dressed with a mixture of Arnebia euochroma and essential oil of Pistacia Atlantica in animal oil. Afterward, their recovery process was photographed daily. Finally, when we saw evidence of rats' wound healing; we killed rats and searched tissue granulation and epithelialization process. The study results showed that Arnebia euochroma and gum mixture at a concentration of 5% of animal oils was more effective compared to honey. Local and regional experiences can be a good source to access pharmaceutical products and services for patients, a scientific reason for this study. We found a more effective ointment for wound dressing. It can help diabetic patients. The oral forms of these plants are recommended to be provided.
1. Athyros V. G., Katsiki N., Karagiannis A., Mikhailidis D. P., 2015. High-intensity statin therapy and regression of coronary atherosclerosis in patients with diabetes mellitus. J Diabetes Complications. 29(1), 142-145.
2. Wang C., Li L., Wang L., Ping Z., Flory M. T., Wang G., Xi Y., Li W., 2013. Evaluating the risk of type 2 diabetes mellitus using artificial neural network: An effective classification approach. Diabetes Res Clin Pract. 100(1), 111-118.
3. Shankaracharya, Odedra D., Samanta S., Vidyarthi A. S., 2010. Computational intelligence in early diabetes diagnosis: a review. Rev Diabet Stud. 7(4), 252-262.
4. Galehdari H., Negahdari S., Kesmati M., Rezaie A., Shariati G., 2016. Effect of the herbal mixture composed of Aloe Vera, Henna, Adiantum capillus-veneris, and Myrrha on wound healing in streptozotocin-induced diabetic rats. BMC Complement Altern Med. 16 (1), 386.
5. Lu L. L., Wan P., Li L. Z., Zhao M. J., Hu J. Y., Zhao Y. F., 2013. Experimental study on topical treatment of diabetic skin ulcers with yi medicine "yi bu a jie" extract. Chin J Integr Med. 19(6), 464-467.
6. Budovsky A., Yarmolinsky L., Ben-Shabat S., 2015. Effect of medicinal plants on wound healing. Wound Repair Regen. 23(2), 171-183.
7. Ho T. J., Jiang S. J., Lin G. H., Li T. S., Yiin L. M., Yang J. S., Hsieh M. C., Wu C. C., Lin J. G., Chen H. P., 2016. The In Vitro and In Vivo Wound Healing Properties of the Chinese Herbal Medicine "Jinchuang Ointment". Evid Based Complement Alternat Med. 2016, 1654056.
8. Khodavaisy S., Rezaie S., Noorbakhsh F., Baghdadi E., Sharifynia S., Aala F., 2016. Effects of Pistacia atlantica subsp. kurdica on Growth and Aflatoxin Production by Aspergillus parasiticus. Jundishapur J Microbiol. 9(7), e35452.
9. Ranjbar H.J.D.J.O.P.S., 2008. Overview of diabetic foot; novel treatments in diabetic foot ulcer. 16 (Suppl. 1), 1-6.
10. Aalaa M., Heshmat R., Larijani B., Mohajeri-Tehrani M. J. D., 2012. Smelil (ANGIPARS™) as a New Herbal Drug on Diabetic Foot Ulcer. J Biomol Res Ther1: e104. doi: 10.4172/2167-7956.1000 e104 Page 2 of 2 Volume 1, Issue 2, 1000e104 J Biomol Res Ther ISSN: 2167-7956 JBMRT, an open access journal htkar AA, et al.(2008) Assessment of maximum tolerated dose of a new herba l drug, Semelil (ANGIPARS™) in patients with diabetic foot ulcer: A Phase I clini-cal trial. 16, 25-30.
11. Rouhipour N., Hayatshahi A., Nikoo M. K., Yazdi N. M., Heshmat R., Qorbani M., 2012. Clinical microbiology study of diabetic foot ulcer in Iran; pathogens and antibacterial susceptibility. Afr J Microbiol Res. 6(27), 5601-5608.
12. Rashidi M. K., Mirazi N., Hosseini A., 2016. Effect of topical mixture of honey, royal jelly and olive oil-propolis extract on skin wound healing in diabetic rats. Wound Medicine. 12, 6-9.
13. Shaw J., Hughes C., Lagan K., Bell P., 2007. The clinical effect of topical phenytoin on wound healing: a systematic review. British Journal of Dermatology. 157 (5), 997-1004.
14. Bergin S. M., Wraight P., 2006. Silver based wound dressings and topical agents for treating diabetic foot ulcers. Cochrane Database Syst Rev(1), Cd005082.
15. Aliasl J., Barikbin B., Khoshzaban F., Naseri M., Sedaghat R., Kamalinejad M., Talei D., Emadi F., Akbari Z., Aliasl F., Jalaly N.Y., Mohseni-Moghaddam P., 2015. Effect of Arnebia euchroma ointment on post-laser wound healing in rats. J Cosmet Laser Ther. 17 (1), 41-45.
16. Fan H.Y., Zhang Z.L., Liu K., Yang M.Y., Lv W.H., Che X., Xu H., Song W.W., 2013. Effectiveness of a hydroxynaphthoquinone fraction from Arnebia euchroma in rats with experimental colitis. World J Gastroenterol. 19(48), 9318-9327.
17. Bahramnejad B., 2014. Identification and characterization of a NBS-LRR class resistance gene analog in Pistacia atlantica subsp. Kurdica. Mol Biol Res Commun. 3(3), 175-185.
18. Ou Y.Y., Jiang Y., Li H., Zhang Y.Y., Lu Y., Chen D. F., 2017. Polysaccharides from Arnebia euchroma Ameliorated Endotoxic Fever and Acute Lung Injury in Rats Through Inhibiting Complement System. Inflammation. 40(1), 275-284.
19. Fan H., Yang M., Che X., Zhang Z., Xu H., Liu K., Meng Q., 2012. Activity study of a hydroxynaphthoquinone fraction from Arnebia euchroma in experimental arthritis. Fitoterapia. 83(7), 1226-1237.
20. Singh B., Sahu P., Jain S., Singh S., 2004. Estimation of naphthaquinones from Arnebia hispidissima (Lehm.) DC. in vivo and in vitro. I. anti‐inflammatory screening. Phytotherapy Research. 18(2), 154-159.
21. Xiong W., Luo G., Zhou L., Zeng Y., Yang W., 2009. In vitro and in vivo antitumor effects of acetylshikonin isolated from Arnebia euchroma (Royle) Johnst (Ruanzicao) cell suspension cultures. Chinese medicine. 4(1), 14.
22. Li Z., Wang J., Ren J., Yi Z., 2004. Effects of topical emu oil on wound healing in scalded rats. Di 1 jun yi da xue xue bao= Academic Journal of the First Medical College of PLA. 24(11), 1255-1256.
23. Desbois A.P., Smith V.J., 2010. Antibacterial free fatty acids: activities, mechanisms of action and biotechnological potential. Applied Microbiology and Biotechnology. 85(6), 1629-1642.
24. Reza F., Javad T., Haddad K. M. H., 2008. Chemical Composition and Oxidative Stability of Kernel Oils from Two Current Subspecies of Pistacia atlantica in Iran. Journal of the American Oil Chemists' Society. 85(8), 723.
25. Kiadaliri A. A., Najafi B., Mirmalek-Sani M., 2013. Quality of life in people with diabetes: a systematic review of studies in Iran. Journal of Diabetes & Metabolic Disorders. 12(1), 54.