The Effect of Rosa Damascena Extract on Diazinon Toxicity in Mice

Subject Areas : Journal of Chemical Health Risks

Oveys  Pourmahdi ¹ (Undergraduate of Veterinary Medicine Faculty, Babol Branch, Islamic Azad University, Babol, Iran)
Tohid  Moradi Gardeshi ² (Undergraduate of Veterinary Medicine Faculty, Garmsar Branch, Islamic Azad University, Garmsar, Iran)
Ali  Amirkhani ³ (Undergraduate of Veterinary Medicine Faculty, Babol Branch, Islamic Azad University, Babol, Iran)
Majid  Gholami-Ahangaran ⁴ (Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran)

Received: 2021-10-05 Accepted : 2023-05-01 Published : 2023-12-01

Keywords: Toxicity, Mice, Oxidative stress, diazinon, Rosa damascene,

Abstract :

Diazinon (DNZ) is one of the most widely used organophosphorus poisons, which plays an important role in chemical pest control by controlling a wide range of chewing and sucking pests in gardens and fields. Diazinon causes death in living organisms by reducing cholinesterase and disrupting nerve cells. In this research, the effect of Rosa damascena extract against DNZ toxicity and oxidative damage induced by DZN in mice was studied. The mice toxified with DNZ (32.5 mg kg-1, intraperitoneally) and treated by pralidoxime (PM) (20 mg kg-1, intraperitoneally) or R. Damascena extract (50, 100, 200 mg kg-1, orally) daily for two weeks. In the end, the acetylcholinesterase (AchE), ferric-reducing antioxidant power (FRAP), Malondialdehyde (MDA), ALT, AST, ALP, and total bilirubin were assayed. DZN administration significantly lowered the AchE, and FRAP and increased the MDA (P < 0.05). However, R. Damascena extracts treatment caused a significant reduction in MDA level and restored the levels of AchE and FRAP as well as significantly prevented the DZN-induced increase in liver aminotransferases, ALP, and total bilirubin. We found that R. Damascena administration nearly eliminated DZN-induced toxicity by preventing oxidative stress in mice.

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