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Manuscript ID : JCHR-2108-1397 (R1) Visit : 336 Page: 621 - 634

10.22034/jchr.2022.1938969.1397

Article Type: Original Research

Evaluation of Antimicrobial Activity of Hydroalcoholic Extracts from Different Parts of Ferula assafoetida L. in Three Regions of South Khorasan Province

Subject Areas : Journal of Chemical Health Risks

Batool Jalili 1 , Sakineh Saeidi-sar 2 , Nahid Masoudian 3 , Asghar Zarban 4 , Mohammad Hasan Namaei 5

1 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2 - Department of Agriculture, Faculty of Shariati, Tehran Branch, Technical and Vocational University (TVU), Tehran, Iran
3 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
4 - Professor, Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
5 - Infectious Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran

Received: 2021-08-28 Accepted : 2022-04-17 Published : 2022-12-01

Keywords: hydroalcoholic extract, Antimicrobial Activity, South Khorasan Province, Ferula asafoetida L,

Abstract :

Due to the increased resistance of bacteria to chemical drugs and the low side effects of medicinal plants, using these plants has been considered in disease treatment. Ferula asafoetida L., as one of the medicinal and native plants of southern Khorasan province (Iran), is used in traditional medicine to treat many diseases. The present study aimed to investigate the antimicrobial activity of hydroalcoholic extract of different parts of Ferula asafoetida L. in three regions of South Khorasan Province.The required chemicals were purchased from Merck and Sigma companies. The microbes were obtained from the Birjand University of Medical Sciences and the Iranian Scientific and Industrial Research Organization. The antimicrobial activity of hydroalcoholic extracts was evaluated by dilution in agar. For this purpose, the plant was collected from three areas: Sarbisheh, Ghayen, and Nehbandan. After identification, drying, and pulverizing, the extracts were prepared by soaking. Some of the extracts showed an inhibitory effect on gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), but none inhibited the growth of Gram-negative bacteria. Moreover, hydroalcoholic extracts of different parts of Ferula asafoetida L. of Sarbisheh had no inhibition effect on the growth of Candida albicans. The results revealed that the hydroalcoholic extracts of the plant could be used as a suitable substitute for chemical drugs to treat diseases.

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