One-pot Synthesis of Polysubstituted Indolizine Derivatives
Subject Areas : PolymerMohammad Piltan 1 , Seyed Amir Zarei 2 , Hassan Saydi 3 , Ashraf Sadat Shahvelayati 4
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Abstract :
An efficient approach to the synthesis of 1,2,3-trisubstituted indolizines is described via one-pot reactions of pyridine and dialkyl acetylendicarboxylate in the presence of ethyl 2-chloroacetoacetate in MeOH at room temperature. The corresponding 1, 2, 3-trisubstituted indolizines may be useful building blocks for the construction of complex indolizine derivatives.