Solvent Free Synthesis of tetra alkyl- phenyl-1H-pyrimido [4, 5-e][1,3,4]Thiadiazine-3,7-diamines

Subject Areas :

mohammad kazem mohammadi ¹

1 - Department of chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.

Received: 2019-01-07 Accepted : 2019-02-26 Published : 2019-03-01

Keywords: 5-e][1, 3, New 1, 5-tetra alkyl methyl- phenyl-1H-pyrimido[4, 4]thiadiazine-3, 7-diamine were synthesized via the cyclocondensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate and further replacement of chlorine atom on the seven number position of pyrimido[4, 5- e][1, 4]thiadiazin by appropriate secondary amines in simple and efficient methods,