Synthesis and Physicochemical Characterization of New Amidic Derivative of Sodium Alginate

Subject Areas :

Shokouh Khodayar ¹ , Mohammad Reza Shushizadeh ^{2 *} , Elham Tahanpesar ³ , Behzad Sharif Makhmalzadeh ⁴ , Haleh Sanaeishoar ⁵

1 - Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.
2 - Marine Pharmaceutical Science Research Center and Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz Iran.
3 - Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran
4 - Nanotechnology research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5 - Department of chemistry, Ahvaz branch, Islamic Azad university

Received: 2023-12-16 Accepted : 2023-12-27 Published : 2023-12-01

Keywords: Ethylenediamine, Amidation reaction, Sodium alginate, Biohydrogel,

Abstract :

In this study, our objective was to synthesis a new derivative of alginate, a natural biocompatible, biodegradable and non-toxic biopolymer to improve the gelling mechanism. For this purpose, ethylenediamine (EDA) was coupled to sodium alginate (NaA) in an aqueous-phase reaction using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC-HCl) and N-hydroxy succinimide (NHS) as coupling reagents to synthesis ethylenediamine-grafted amphiphilic sodium alginate-amide derivative (NaA-g-EDA). Synthesized derivative showed no environmental sensitivity but the swelling percentage of hydrogels shows that hydrogels obtained from NaA-g-EDA had higher water absorption compared to non-functionalized sodium alginate. It seems that hydrogels can uptake water more than 100% of their weight but in a slow manner. This character is a perfect property for wound dressing. Biodegradable synthesized hydrogel can be decomposed into non-toxic by-products. The purity and grafting of copolymers were characterized using fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1HNMR), X-ray diffraction (XRD), and elemental analysis (CHNX). These analytical methods confirmed the structure of NaA-g-EDA.