Solvent-free One Pot Biginelli Method for Synthesis of new Dihydropyrimidinone compounds

Subject Areas :

1 - Department of polymer engeeniering, Tehra Science and Reaserch Branch, Islamic Azad University,Tehran, Iran

Received: 2019-01-02 Accepted : 2019-02-28 Published : 2019-03-01

Keywords: Solvent-free, One-pot, Biginelli reaction, Dihydropyrimidinones,

Abstract :

An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.

References:

Synthesis and spectroscopic study of a new diamidophosphoester, (4-CH3-C6H4O)((CH3)2CHNH)2P(O)
Print Date : 2023-09-18
One-pot synthesis of 1,2,4,5-tetrasubstituted Imidazoles using BiFeO3
Print Date : 2020-05-01
Tributyl hexadecyl phosphonium bromide as a new and efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidinones/thiones via a three component condensation reactions
Print Date : 2019-06-01
Theoretical study of HCX (NH2) (X= O, S, and Se) analogs in the gas phase: Electronic Structure, Natural Bond Orbital (NBO) & Natural Resonance Theory (NRT)
Print Date : 2022-03-01
Synthesis 3 and 4-Dihydropyrimidinone and Thiones using Multi-Walled Carboxylated Carbon Nanotube Catalysts
Print Date : 2019-08-01
Study of the effects of solvent and temperature on the Connections of the MTX and L-FMTX with single-walled carbon nanotubes using QM and MM
Print Date : 2022-09-01

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Solvent-free One Pot Biginelli Method for Synthesis of new Dihydropyrimidinone compounds