Synthesis of alkyl 2-(4-oxoquinazolin-3(4H)-yl) acrylate by nucleophilic additionof alkyl propiolates catalysed by Ph3P

Subject Areas :

1 - Department of Organic Chemistry, Karaj Branch, Islamic Azad university, Karaj, Iran
2 - Department of Organic Chemistry, Karaj Branch, Islamic Azad university, Karaj, Iran

Received: 2016-05-31 Accepted : 2016-05-31 Published : 2012-05-01

Keywords: Alkyl propiolates, Triphenylphosphine, 4-Hydroxyquinazoline, alkylacrylat,

Abstract :

4-Hydroxyquinazoline undergoes neutral conditions with alkyl propiolates in the presence of triphenylphosphine (0.26g), and by α substituation the corresponding 2-(4-oxoquinazolin-3(4H)-yl acrylate was obtained in good yields.

References:

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Synthesis of alkyl 2-(4-oxoquinazolin-3(4H)-yl) acrylate by nucleophilic additionof alkyl propiolates catalysed by Ph3P