A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition

Subject Areas :

Ali Ezabadi ¹ (Department of Chemistry, Faculty of Sciences, Islamic Azad University, Central Tehran Branch, Sanat Square, Iran)
Fatemeh Tosan ² (Department of Chemistry, Faculty of Sciences, Islamic Azad University, Central Tehran Branch, Sanat Square, Iran)

Received: 2016-05-25 Accepted : 2016-05-25 Published : 2011-05-01

Keywords: Hantzsch 1, 4 – dihydropyridines, PEG-400, Three-component reaction, catalyst-free, Aldehydes, ethyl acetoacetate, ammonium acetate,

Abstract :

An efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at 110°С and the products were obtained in good to high yields.

References:

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A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition