Uranyle Complexes: synthesis, evaluation of biological activity

Subject Areas :

Shahriar Ghammamy ¹ (Department of Chemistry, Faculty of Science, Imam Khomeini International University,Ghazvin, Iran)
Rozita Hosseinzadeh Khezri ² (Department of Chemistry, Faculty of Science, Imam Khomeini International University, Ghazvin, Iran)
Zahra Amini ³ (Department of Chemistry, Faculty of Science, Imam Khomeini International University, Ghazvin, Iran)
Monir Al-sadat Mirrahimi ⁴ (Department of Chemistry, Faculty of Science, Imam Khomeini International University, Ghazvin, Iran)
Masoud Soleimani ⁵ (Department of Hematology, Faculty of Medicine, Tarbiat Modarres University, P.O. Box, Tehran, Iran)
Saeid Kaviani ⁶ (Department of Hematology, Faculty of Medicine, Tarbiat Modarres University, P.O. Box, Tehran, Iran)

Received: 2014-01-14 Accepted : 2014-05-14 Published : 2014-06-01

Keywords: Inorganic, Uranyl complex-donor ligands, Schiff bases, Anticancer Activity,

Abstract :

In this research, some of the inorganic complexes of uranyl with N- donor ligandswere synthesized. Complexes were characteriezed by FT-IR and UV spectra, ¹HNMR,¹³CNMR and some physical properties. The uranyl unit (UO2) is composed of a center ofuranium atom with the charge (+6) and two oxygen atom by forming two U=O double bonds.The structure is linear (O=U=O, 180) and usually stable. So other ligands often coordinate tothe U atom in the plane perpendicularly to the O=U=O axis. The antitumor activity of some ofligand and their complexes against a panel of human tumor cell lines (HT29: Haman colonadenocarcinoma cell line T47D: human breast adenocarcinoma cell line) were determined byMTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay. These datasuggest that some of these compounds provide good models for the further design of potentantitumor compounds.

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