مروری بر کاربرد پروبیوتیک ها ومتابولیت های آن در درمان بیماریها

Subject Areas : Biotechnological Journal of Environmental Microbiology

Mohaddeseh Larypoor ^{1 *} , Hamideh Karbalaeiheidar ² , Kimia Basiji ³ , Maede Ebrahimi ⁴

1 - گروه میکروبیولوژی ، دانشکده علوم پایه ، واحد تهران شمال ، دانشگاه آزاد اسلامی ، تهران ، ایران
2 - دانش آموخته ارشد بیوتکنولوژی، دانشکده علوم زیستی، گروه بیوتکنولوژی،دانشگاه آزاد اسلامی ،واحدتهران شمال، تهران، ایران
3 - دانش آموخته ارشد میکروبیولوژی، دانشکده علوم زیستی، گروه بیوتکنولوژی،دانشگاه آزاد اسلامی ،واحدتهران شمال، تهران، ایران
4 - دانش آموخته ارشد میکروبیولوژی، دانشکده علوم زیستی، گروه بیوتکنولوژی،دانشگاه آزاد اسلامی ،واحدتهران شمال، تهران، ایران

Received: 2023-10-30 Accepted : 2023-11-20 Published : 2023-11-23

Keywords: پروبیوتیک, سین بیوتیک, پری بیوتیک, پست بیوتیک,

Abstract :

 دستگاه گوارش انسان حاوی میکروبیوتای غنی و پیچیده ای است که در عملکرد دستگاه گوارشی، فرایندهای ایمونولوژیک و درمسیر برخی از بیماری ها از جمله دیس بیوز نقش مهمی را ایفا می کند. بر طبق تحقیقات مجموعه میکروبیوتای دستگاه گوارش می تواند، بر روی کاهش یا افزایش جمعیت میکروبیوم پوست، دستگاه عصبی  و قسمتهای دیگر بدن انسان تأثیر گذار باشد. مصرف مکملهای  غذایی فراسودمند به عنوان یک استراتژی بالقوه و امیدوارکننده برای تنظیم میکروبیوتای روده وبهبود بیماری های تحث تأثیر آن در حال ظهور است. انواع مکمل های پروبیوتیک می تواند شامل مخمرها، باکتری ها و انواع پری بیوتیک شامل پلی ساکارید های غیر قابل هضم با منشاء گیاهی، میکروبی، قارچهای کلاهدارو جلبکها  باشند. همراه شدن پروبیوتیک ها و پری بیوتیکها منجر به تولید فراورده های سینبیوتیک با اثرات قوی تر در ارتقاء سلامت انسان می شود. علاوه بر این موارد، پست بیوتیک ها محصولات جانبی متابولیک آزاد شده از پروبیوتیک ها می باشند و پس از تجزیه باکتری‌ با اثرات سلامتی زیادی مانند تنظیم سلامت روده و تقویت سیستم ایمنی، مانند پروبیوتیک‌ها مورد استفاده قرار گرفته اند.   تا به امروز در مطالعات انجام شده، اثرات افزایش پروبیوتیک های روده و کاهش میکروارگانیسم های بیماریزا پری بیوتیک و اثرات ضد سرطانی ، التهابی  و ایمونومدولاتوری پست بیوتیک ها و سین بیوتیک ها  بر روی میکروبیوم دستگاه گوارشی اثبات شده لذا تهیه مکمل های فراسودمند ومصرف آنها افزایش پیدا کرده است.

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