The kinetic parameters of drug compounds adsorption onto mesoporous materials

Subject Areas : Journal of Physical & Theoretical Chemistry

Masoud. Giahi ¹ , Abdollah. Falah Shojaie ² , Farkhondeh. Mirsfa Moqadam ³

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Received: 2015-05-09 Accepted : 2015-05-09 Published : 2008-05-01

Keywords: MCM-41, Psudeoephedrine hydrochloride, Desorption, Adsorption,

Abstract :

The discovery of mesoporous molecular sieves, MCM-41, which possesses a regular hexagonalarray of uniform pore openings, aroused a worldwide resurgence in this field. This is not onlybecause it has brought about a series of novel mesoporous materials with various compositionswhich may find applications in catalysis, adsorption, and guest-host chemistry, but also it hasopened a new avenue for creating of the zeotype materials. This paper presents a comprehensiveoverview of recent advances in the field of MCM-41. Adsorption of drug molecules such asPseudeoephedrine hydrochloride onto mesoporous molecular sieves (MCM-41) from aqueoussolution has been investigated systematically using batch experiments in this study. Resultsindicate that Pseudeoephedrine hydrochloride adsorption is initially rapid and the adsorptionprocess reaches a steady state after 2 min. The adsorption isotherms are well described by theLangmuir model. Based on the results, it suggests that the adsorption is primarily brought about byhydrophobic interaction between drug molecules and MCM-41 surface.