Efficient one-pot synthesis and characterization of 13-Acetyl-9-methyl-11-oxo-8-oxa-10,12-diazatricyclo [7.3.1.0^2,7] trideca-2,4,6-triene

Subject Areas : Journal of Physical & Theoretical Chemistry

Hojatollah Salehi ¹ , Mohammad Rabbani ² , Qian-Rong Li ³ , Qing-xiang Guo ⁴

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Received: 2015-04-27 Accepted : 2015-04-27 Published : 2005-05-01

Keywords: Oxygen-bridged dihydropyrimidi, Intramolecular Michael-additio, One-pot-solvent-free synthesis, NMR and EL_TOFMS,

Abstract :

An efficient and environmentally friendly procedure for one-pot synthesis of 13-acetyl-9-methyl-11-ox-8-oxa-10,12-diazatricyclo [7.3.1. ] trideca-2,4,6-triene from salicylaldehyde, acetylaceton and urea via Biginelli condensation and intramolecular Michael-addition by using magnesium bromide as an expensive and easily available catalyst under solvent-free condition is desired. The structural elucidation of the product is also described by -and -NMR spectra and the detailed fragmentation routs of EI-TOFMS