Potential of magnetite nanoparticles with biopolymers loaded with gentamicin drug for bone cancer treatment

Subject Areas : Journal of Nanoanalysis

Ehsan Nassireslami ¹ , Mehdi Motififard ² , Bahareh Kamyab Moghadas ³ , Zahra Hami ⁴ , Amir Jasemi ⁵ , Amin Lachiyani ⁶ , Reza Shokrani Foroushani ⁷ , Saeed Saber-Samandari ⁸ , Amirsalar Khandan ⁹

1 - 1 Toxicology Research Center, AJA University of Medical Sciences, Tehran; Iran 2 Department of Pharmacology and Toxicology, AJA University of Medical Sciences, Tehran, Iran
2 - Department of Orthopedic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 - Department of Chemical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran
4 - Toxicology Research Center, AJA University of Medical Sciences, Tehran; Iran
5 - Department of Chemical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran
6 - Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
7 - Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
8 - New Technologies Research Center, Amirkabir University of Technology, Tehran, Iran
9 - New Technology Research Center, Amirkabir University of Technology, Tehran, Iran

Received: 2021-10-19 Accepted : 2021-10-19 Published : 2021-09-01

Keywords: Magnetic nanoparticles, magnetization, Drug delivery system, Malignant Tumor,

Abstract :

Objective(s): Due to the natural bone microstructure, the design and fabrication ofporous ceramic scaffold nanocomposite materials coated with a thin layer of a naturalthe polymer can provide an ideal scaffold for bone tissue engineering. This study aimed tofabricate multi-component porous magnetic scaffolds by freeze-drying (FD) techniqueusing a gelatin polymer layer coated with a gentamicin drug.Methods: Magnetic nanoparticles (MNPs) can be manipulated and controlled byan external magnetic field gradient (EMFG) that is inherent in the magnetic field'spermeability within human tissues. In the present work, unlike the usual ceramic/polymer composite scaffold, the ceramic components, and the magnet were placedtogether in the reaction medium from the beginning, and bioceramics were replacedin the composite polymer network and then coated with a drug-loaded polymer. Toevaluate the morphology of the magnetic scaffold, scanning electron microscopy(SEM) was utilized to evaluate the microstructure and observe the porosity of theporous tissue.Results: After analyzing the SEM images, the porosity of the scaffolds was measured,which was similar to the normal bone architecture. The addition of gentamicin tothe gelation was investigated to monitor the drug delivery reaction in the biologicalenvironment. The magnetic properties of the sample were evaluated using thehyperthermia test for 15 seconds at the adiabatic conditions. Also, the porosity valueincreased from 55% to 78% with the addition of MNPs to the based matrix.Conclusions: The results of this study showed that gentamicin-gelatin-coated onporous ceramic-magnet composite scaffolds could be used in bone tissue engineeringand apply for treatment of bone tumors, because of their similarity to the bonestructure with good porosity.