A Novel Microwave-Assisted, One-Pot Three Component Synthesis Based Upon Environmentally Protection Principles
Subject Areas : Micro & Nano MechanicsKourosh Motevalli 1 * , Zahra Yaghoubi 2
1 -
2 - IT Department, South Tehran Branch,Islamic Azad University, Tehran, Iran
Keywords: Three-component reaction, Pyridine, Microwave-assisted reaction, Solvent-free, fluid, synthesis,
Abstract :
In this research, a new synthesis method of 2-phenylH-imidaze(1,2-a] pyridines is, obtained ¡ from a one-pot, three-component reaction between pyridine, urea (or guanidine) and a-bromoketones under microwave irradiation by observing the obvious principles of fluid mechanics and solvent-free conditions in excellent yields. One-pot multicomponent reactions have been disclosed as an effective instrument for atom economic and fluid mechanics obvious synthesis principles with regards to their convergence, productivity, and generation of highly diverse and complex products from easily available starting materials.
Green chemistry in relationship with fluid mechanics obvious principles emphasizes the importance for environmentally clean and safe synthesis, which contains high atom efficiency, elimination of dangerous chemicals, and easy separation with recovery and reuse of chemicals. In this way, the utility of microwave energy in synthetic organic chemistry has been increasingly recognized as compared with conventional heating. Reactions promoted by microwave irradiation (MWI) have shown an environmentally friendly nature, greater selectivity, and enhanced reaction rate. Therefore, the MWI-mediated multicomponent reaction has erected a specific attractive synthetic strategy for the fast and efficient library generation.