Review High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on chiral stationary phases

Subject Areas : Journal of the Iranian Chemical Research

Jahanbaksh Ghasemi ^{1 *} , Mahmood Chamsaz ² , Saeid Asadpour ³ , Ali Sarafraz Yazdi ⁴

1 - Department of Chemistry, Faculty of Sciences, K.N. Toosi University of Technology, Tehran, Iran
2 - Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Iran
3 - Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Iran
4 - Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Iran

Received: 2009-02-16 Accepted : 2009-03-15 Published : 2009-03-20

Keywords: HPLC, Enantiomer separation, Drug, Chiral stationary phases,

Abstract :

In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. High-performance liquid Chromatography is a very useful method for the direct separation of enantiomers. However, about 30−40 years ago, commercially available chiral stationary phases were very limited. Researchers developed many novel chiral stationary phases for gas and liquid chromatography, and found these phases were effective practically to the separation and analysis of various chiral compounds. Enantioseparation of drugs with multiple chiral centers is challenging. This review describes resolution of some drugs with multiple chiral centers using polysaccharide-type chiral stationary phases.