Phytotherapy in Burn Wound Healing: A Review of Native Iranian Medicinal Plants
Subject Areas : Journal of Chemical Health RisksAlireza Esmaeili 1 , Pouya Parsaei 2 , Mohammadreza Nazer 3 , Ronak Bakhtiari 4 , Halleh Mirbehresi 5 , Hossein Safian Boldaji 6
1 - Non-Communicable Disease Research Center, Ilam University of Medical Sciences, Ilam, Iran |Assistant Professor of Hematology and Oncology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
2 - Department of Food Hygiene, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran |Research Center of Nutrition and Organic Products (RCNOP), Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
3 - School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 - Assistant Professor, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5 - Assistant Specialist in Internal Neurology and Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6 - Department of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Keywords: Iran, Medicinal Plants, Treatment, Wound healing, Burn,
Abstract :
Studies have shown that burn wounds are one of the most severe forms of trauma which may cause disability, morbidity and mortality, stupendous hospital costs, and emotional disturbance. In spite of the therapeutic effects of synthetic drugs, due to their unwanted side effects, the tendency of people to use these drugs has been decreasing, contrary to the use of natural origin drugs. Medicinal plants that can be formulated to treat and repair the wound should be identified. Therefore, in this article a number of native Iranian medicinal plants that have been studied and their healing effects on burn wounds have been reported are discussed. In this review article, the keywords medicinal plants, burn, burn wound repair, burn wound and Iran were used to search for relevant articles indexed in databases such as IranMedex, Scientific Information Database, Google Scholar, Scopus, Institute for Scientific Information, Web of Science and PubMed. Based on the results, the medicinal plants Aloe vera (L.) Burm.f., Matricaria chamomilla L, Quercus brantii Lindl., Cydonia oblonga Mill., Scrophularia striata, Camellia sinensis (L.) Kuntze, Portulaca oleracea L, Cinnamomum zeylanicum Blume, Achillea talagonica Boiss., Olea europaea L., Hypericum perforatum L., Cucurbita pepo L., Teucrium polium L., Myrtus communis, Brassica oleracea L., Plantago major L., Malva sylvestris L., Arnebia euchroma (Royle) I.M.Johnst., Cucurbita moschata Duchesne, Achillea millefolium L., Lythrum salicaria L., Crocus sativus L. and Allium sativum L. are some of the most important herbal remedies to repair burn wounds. According to the various researches on the medicinal plants, the anti-inflammatory, antimicrobial and antimicrobial effects of these plants have been scientifically demonstrated, which has led to information that can be used to produce antimicrobial drugs for infectious and burn wounds.
1. Burned adults. 2002. cluster analysis of the coping with burns questionnaire (CBQ).Burns. 28, 549- 54.
2. Lawrence J.W., Fauerbach J.A., Heinberg L., Doctor M., 2004. Visible vs hidden scars and their relation to body image. J Burn Care Rehabil. 25(1), 25-32.
3. Burns, 2009. the sixth cause of death in Iran. [Cited 2009 0ct 5]. Available from :http :// www. hamshahrionline.ir/news.aspx?id=92205
4. Forjuoh S.N., 2006. Burns in low- and middle-income countries: a review of available literature on descriptive epidemiology, risk factors, treatment and prevention. Burns. 32, 529-37
5. Mirmohammadi S.J., Mehrparvar A.H., Jalilmanesh M., Kazemeini K., Delbari N., Mostaghaci M., 2012. An epidemiologic survey on burns in Yazd from 2008 till 2009. Acta Med Iran. 50(1), 70-5.
6. liechukwu S.T., 2006. Psychiatry of the medically ill in the burn unit. Psychiatric Clinics of North America. 2, 129-47
7. ChurchD., 2006. BurnWound Infections. Burns. 19, 9-10.
8. Atiyeh B., Masellis A., Conte C., 2010. Optimizing burn treatment in developing low- and middle-income countries with limited health care resources (part 1). Ann Burns Fire Disasters. 23(1),13-18.
9. Schwartz S., Spencer F.G., 2007. Principle of Surgery. 10th Edition, Mc Grow Hill: New York, 3-9.
10. Groohi B., Alaghebandan R., Lari A.R., 2002. Analysis of 1098 burn patients in province of Kurdistan, Iran. Burns. 28, 569-74.
11. Maghsoudi H., Pourzand A., Azarmir G., 2005. Etiology and outcome of burns in Tabriz, Iran: An analysis of 2963 cases. Scand J Surg. 94, 77-81
12. Salmon J.K., Armstrong C.A., Ansel J.C., 1994. The skin as an immune organ. West J Med. 160, 146–152.
13. Niemi T., Svartliny N., 1998. Haemostatic disturbances in burned patient in early exsicsion and skin grafting. Blood Coagul Fibrinolysis. 9(1), 19-28.
14. Speakers B.G., 1997. Immunological responses to termal injury. Burns. 23(2), 106-13.
15. Maekavat Kajihara H., Okabayashik Otani M., Yuge O., 2002. Impairment of splenic B, T lymphocytes in the early period after severe thermal injury: immunohistochemical and electron microscopic analysis. Burns. 28(4), 329-39.
16. Klein R., 2002. Severe background and procedural burn pain: develop a pain control plan, drug therapy perspective.17(20), 5-8.
17. Byers J., Bridges S., Kijek J., Laborde P., 2001. Burn patients pain and anxiety experiences. Burn Care Rehab. 22(2), 144-49.
18. Morgan E.D., 2000. Ambulatory management of burns. Am Fam Physician. 62(9), 1-9.
19. Willebrand M., Anderson G., Kildal M., Ekselius L., 2002. Exploration of coping patterns in burned adults: cluster analysis of the coping with burns questionnaire (CBQ). Burns. 28, 549- 54.
20. Lawrence J.W., Fauerbach J.A., Heinberg L., Doctor M., 2004. Visible vs hidden scars and their relation to body image. J Burn care Rehabil. 25(1), 25-32.
21. Mallouk Y., Vayssier-Taussat M., Bonventre J.V., Polla B.S., 1999. Heat shock protein 70 and ATP as partners in cell homeostasis (Review). Int J Mol Med. 4(5), 463-74.
22. Rubin B.B., Romaschin A., Walker P.M., Gute D.C., Korthuis R.J., 1996. Mechanisms of postischemic injury in skeletal muscle: intervention strategies. J Appl Physiol. 80(2), 369-87.
23. Venkatachalam M.A., Weinberg J.M., 1994. Mechanisms of cell injury in ATP-depleted proximal tubules. Role of glycine, calcium, and polyphosphoinositides. Nephrol Dial Transplant. 9(4), 15-21.
24. Seyyedi M., 1997. Burns. 1th ed. Tehran: Eshtiagh. 24-6.
25. Rakhshandeh H., Mahdavi-shahri N., 2003. The effect of topical administration of bovine eye vitreous on the improvement of burn wound healing caused by the .Dutch on the skin of male rabbits. Hormones J. 10, 48-52.
26. Brunicardi F.C., Schwartz S.I., 2005. Schwartz's principles of surgery. 8th ed. NewYork: McGraw Hill, 23.
27. Holmes J.H., Heimbach D.M., 2005. Burns. In: Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Pollock RE. Schwartz's principles of surgery. 8th ed. NewYork: McGraw- Hill. 204-28.
28. Wyatt D., McGowan D.N., Najarian M.P., 1990. Comparison of a hydrocolloid dressing and silver sulfadiazine cream in the outpatient management of second degree burns. J Trauma. 30(7), 857-67.
29. Muthu C., Ayyanar M., Raja N., Ignacimuthu S., 2006. Medicinal plants used by traditional healers in Kancheepuram district of Tamil Nadu, India. J Ethnobiol Ethnomed. 2, 43-45.
30. Ashrafi K., Esmaeli E., Shahinfard N., Ansari R., Parvin N., Namjoo A.R, 2011. The effect of hydroalcoholic extracts of Zizipus vulgaris L. on burn healing. J Shahrekord Uni Med Sci. 12(4), 78-82.
31. Ghahraman A., Attar, F. 1998. Biological diversity of Iranian plant series. Tehran Medical University: Press, Iran. 24-26.
32. Goertz O., Ring A., Buschhaus B., Hirsch T., Daigeler A., Steinstraesser B., 2011. Influence of anti-inflammatory and vasoactive drugs on microcirculation and angiogenesis after burn in mice. Burns. 37(4), 656-64.
33. Nouri A., Heidarian E., Amini-Khoei H., Abbaszadeh S., Basati G., 2019. Quercetin through mitigation of inflammatory response and oxidative stress exerts protective effects in rat model of diclofenac-induced liver toxicity. J Pharmacy Pharmacog Res. 7(3), 200-212.
34. Shahanipour K., Sadeghi M., 2016. The therapeutic effects of Aloe vera and Honey on burn wounds in rats. J North Khorasan Uni Medical Sci. 8(1), 71-81.
35. Jarrahi M., Emami Abarghooee M., 2008. The effect of hydroalcoholic matricaria chamomilla extract on cutaneous burn wound healing in albino Rats. J Gorgan Univ Med Sci. 10(2), 22-26
36. Nikrooze L., Jafari Barmak M., Naghmachi M., Ghafarian shirazi H., Dehghani N., 2013. Study of Jaft Aqueous Extract and Silver Sulfadiazine on Burn Healing in Male Rat. Yasuj Uni Med Sci J. 18(2), 107-114.
37. Tajoddini A., Rafieian-kopaei M., Namjoo A.R., Sedehi M., Ansari R., Shahinfard N., 2013. Effect of Ethanolic Extract of Cydonia Oblonga Seed on the Healing of Second-Degree Burn Wounds. Yasuj Uni Med Sci J. 17(6), 72, 494-501.
38. Azhdari-Zarmehri H., Nazemi S., Ghasemi E., Musavi Z., Tahmasebi Z., Farsad F., Farzam A., 2014. Assessment of Effect of Hydro-Alcoholic Extract of Scrophularia Striata on Burn Healing in Rat. J Babol Univ Med Sci. 16(5), 42-48.
39. Asadi S.Y., Zamiri A., Ezzati S., Parsaei P., Rafieian M., Shirzad H., 2011. Effect of alcoholic extract of green tea (Camellia sinensis) on the healing process in surgical and burn wounds in rats. Journal of Birjand Uni Med Sci. 18(1), 1-9.
40. Rafiee-Vardanjani L., Sahinfard N., Rahimi-Madiseh M., Ansari- Samani R., Rahimi M., Parvin N., Taji-Eshkaftaki F., 2012. Effect of Portulaca oleracea L vice versa silver sulfadiazine on burn wound healing in Balb/c mice. J Shahrekord Univ Med Sci. 13(6), 92 100.
41. Ahmadi D., Ghasemi N., 2016. The effect of cinnamon extract (Cinnamomum zeylanicum) topically and the injection burn wound healing in diabetic rats compared with normal rats. Islamic Azad Uni Med Sci J. 25(1), 27-32.
42. Habibian S., Karimi I., Tavakoli T., Kaboutari J., 2013. The effects of Achillea talagonica alcoholic extract on cutaneous burn wounds healing in rabbit. Iranian Journal of Vetrinary Clinical Sciences. 7(2), 33-44.
43. Akbari G., Shahbazfar A., Kianifard D., Rezaei H., Shokrollahi S., Mohebi D., 2017. Microscopic Study of the Healing Effects of the Mixture of Olive Oil and Lime Water on the Second Degree Burning in Rats. Sci J Ilam Uni Med Sci. 24(6), 169-176.
44. Momeni E., Aroi N., Aroi M., Jafari Barmak M., Mahmoudi R., Malekzadeh J.M., 2014. The Effect of Hypericum Perforatum Extract and 1 % Silver Sulfadiazine on Second Degree Burn Wound Healing in Male Rats. Armaghane-danesh. 19(7), 625-632.
45. Naghsh N., Aboutalebi F., Karam Seychani S., 2013. Designing a New Nano-Plant Composite of Cucurbita pepo for Wound Repair of Skin in Male Albino Mice: A New Nano Approach for Skin Repair. J Fasa Uni Med Sci. 3(1), 27-33.
46. Ansari M., Alizadeh A.M., Paknejad M., Khaniki M., Naeimi S.M., 2009. Effects of Teucrium Polium Honey on Burn Wound Healing Process. J Babol Uni Med Sci. 11(3), 7-12.
47. Jorsaraei S.Gh., Moghadamnia A.A., Firoozjahi A.R., Miri S.M., Omranirad A., Saghebi R., Hashemi S.F., 2006. A comparison on histopathological effects of Myrtle extract and silver sulfadiazine 1% on healing of second degree burn wound in rats. J Qazvin Uni Med Sci. 10(1), 5-16.
48. Hassanzadeh G.H.R., Hajmanouchehri F., Beheshtiroi A., Hassanzadeh N., Shafigh N., Barzroudipour M., Baazm M., Choobineh H., 2013. Comparing Effects of Silver sulfadiazine, Sucralfate and Brassica oleracea extract on Burn Wound Healing. Life Sci J. 10(6s), 852-861.
49. Amini M., Mohammadiaa, Kherad M., 2019. Effect of plantago major on Burn Wound Healing in Rat. World J Plast Surg. 8(1), 51–57.
50. Ghasemi Pirbalouti A., Yousefi M., Nazari H.A., Karimi I., Koohpayeh A., 2009. Evaluation of Burn Healing Properties of Arnebia euchroma and Malva sylvestris. Elect J Biol. 5(3), 62-66.
51. Bahramsoltani R., Farzaei M.H., Abdolghaffari A.H., Rahimi R., Samadi N., Heidari M., Esfandyari M.A., Baeeri M., Hassanzadeh G.H.R., Abdollahi M., Soltani S., Pourvaziri A., Amin G.H.R., 2017. Evaluation of phytochemicals, antioxidant and burn wound healing activities of Cucurbita moschata Duchesne fruit peel. Iranian J Basic Med Sci. 20, 798-805.
52. Shokouhi F., Jalali S., Tajik H., Hadian M., 2012. Efficacy of topical application of alcoholic extract of yarrow in the healing process of experimental burn wounds in rabbit. Comp Clin Patholy. 21(2), 177–181
53. Vafi F., Bahramsoltani R., Abdollahi M., Manayi A., Hossein Abdolghaffari A., Samadi A.,, Hassanzadeh G., Jamalifar H., Baeeri M., Heidari M., Khanavi M., 2016. Burn Wound Healing Activity of Lythrum salicaria L. and Hypericum scabrum L. Wounds, 29;WNDS20160929-2. Online ahead of print.
54. Khorasani G.A., Hosseinimehr S.J., Zamani P., Ghasemi M., Ahmadi A., 2008. The Effect of Saffron (Crocus Sativus) Extract for Healing of Second-degree Burn Wounds in Rats. Keio J Med. 57(4), 190－195.
55. Hashemi S.R., Davoodi H., 2012. Herbal plants as new immuno-stimulator in poultry industry: a review. Asian J Anim Vet Adv. 3(3), 1683-9919.
56. Eamlamnam K., Patumraj S., Visedopas N., Thong-Ngam D., 2006. Effects of Aloe Vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats. World J Gastroenterol. 7, 12(13), 2034-9.
57. Chithra P., Sajithlal G.B., Chandrakasan G., 1998. Influence of Aloe Vera on the healing of dermal wounds in diabetic rats. J Ethnopharmacol. 59(3), 195-201.
58. Davis R.H., Maro N.P., 1989. Aloe Vera and gibberellin. Anti-inflammatory activity in diabetes. J of the American Podiatric Medical Association. 79(1), 24-6.
59. Salamon I., 2007. Effect of the internal and external factors on yield and qualitative-quantitative characteristics of chamomile essential oil. J Sci Ind Res. 99, 132-9.
60. Franze C., Hoelzel J., Voemel A., 2011. Preliminary morphological and chemical characterization of some population and varieties of Matricaria chamomila L. Acta Hortic. 2, 379-85.
61. Santieseban-Lopez A., Palou E., Lopez-Malo A., 2007. Susceptibility of food-borne bacteria to binary combination of antimicrobials at selected aw and pH. J Appl Microbiol. 102, 486-97.
62. Mole S., Waterman P.G., 1987. Tannic acid and proteolytic enzymes: enzyme inhibition or substrate deprivation?. Phytochem. 26, 99-102.
63. Safary A., Motamedi H., Maleki S., Seyyednejad S.M., 2009. A preliminary study on the antibacterial activity of Quercus brantii against bacterial pathogens, particularly enteric pathogens. Inter J Bot. 1-5.
64. Zargari A., 1988. Pharmaceutical plants. 2nd ed., Tehran: Amir Kabir Publications. 563-5.
65. Mozafarian V.A., 1999. Khuzastan flora: Agriculture natural resources research. 1st ed. Ahvaz: Publication Center of Khuzestan Province. pp.353.
66. Park S.U., Park N., Kim Y.K., Suh S.Y., Eom S.H., Lee S.Y., 2009. Application of plant biotechnology in the medicinal plant Rehmannia glutinosa Liboschitz. J Med Plants Res. 3(13), 1258-63.
67. Recio M.C., Giner R.M., Manez S., Rios J.L., 1994. Structural considerations on the iridoids as anti-inflammatory agents. Planta Med. 60(3), 232-4.
68. Tatum M., 2007. What Is Red Light Therapy. [online]. Available from URL: http://www.wisegeek.com/what-is-red-lighttherapy. htm
69. Hsu S., 2005. Green tea and the skin. J Am Acad Dermatol. 52(6), 1049-59.
70. Schuman M., 2001. Over view of Purslane Edible and Medicinal Herb. NNFA Today. 15 (6), 10-12.
71. Simopoulos A.P., Norman H.A., Gillaspy J.E., Duke J.A., 1998. Common Purslane a souree of Omega 3- fattyaads and antioxidants. J. Ethnopharmacol. 22, 33 - 44.
72. Yan J., Sun L.R., Zhou Z.Y., Chen Y.C., Zhang W.M., Dai H.F., 2012. Homoisoflavonoids from the medicinal plant Portulaca oleracea. Phytochem. 80(0), 37-41.
73. Weng Q., Yuan K., Zhang H., Xiong J., Wang C., Xu G., Determination of dopamine and norepinephrine in Portulaca oleracea L. by micellar electrokinetic capillary chromatography with amperometric detection. Se Pu. 23(1), 18-21.
74. Mohammad Beigi N., Haghighi Asl A., Hormozi F., 2008. Investigation of various factors Drasansgyry of cinnamon. College of Engineering. 42(2), 199-203.
75. Parthasarathy V.A., Chempakam B., Zachariah T.J., 2008. Chemistry of Spices. Chapter 7. pp 3.
76. Owen R.W., Haubner R., Würtele G., Hull E., Spiegelhalder B., Bartsch H., 2004. Olives and olive oil in cancer prevention. Eur J Cancer Prev. 13(4), 319-26.
77. Huang Z.R., Lin Y.K., Fang J.Y., 2009. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology. Molecules. 14(1), 540-54.
78. Zargari A., 1996. Medicinal plants. Tehran: Tehran University Publications, Vol 3, 513- 514.
79. Mukherjee P.K., Verpoorte R., Suresh B., 2000. Evaluation of in-vivo wound healing activity of hypericum patulum (family: hypericaceae) leaf extract on different wound model in rats. J Ethnopharmacol. 70(3), 315-21.
80. Jean D., Pouligon M., Henriot A.C., 2006. Pharmacological activity of three commercial hypericum perforatum preparations in mice. Phytother Res. 20(8), 653-4.
81. Sanchez Mateo C.C., Bonkanka C.X., Hernandez Perez M., Rabanal R.M., 2006. Evaluation of the analgesic and topical anti-inflammatory effects of Hypericum reflexum L. fil. J Ethnopharmacol. 107(1), 1-6.
82. Lazos E.S., 1986. Nutritional, fatty acids and oil characteristics of pumpkin and melon seeds. J Food Sci. 51(5), 1382-3.
83. Bombardelli E., Morazzoni P., 1997. Curcubita pepo L. Fitoterapia. 68(4), 291-302.
84. Fissore E.N., Matkovic L., Wider E., 2009. Rheological properties of pectin-enriched products isolated from butternut (Cucurbita moschata Duch ex Poiret). Food Sci Tech. 42(8), 1413-21.
85. Caili F., Huan S., Quanhong L., 2006. A review on pharmacological activities and utilization technologies of pumpkin. Plants Food Hum Nutr. 61(8), 73-80.
86. Xia T., Wang Q., 2006. Antihyperglycemic effect of Cucurbita ficifolia fruit extract in streptozotocin-induced diabetic rats. Fitoterapia. 77(7-8), 530-3.
87. Ogalesyan G.B., Galstyan A.M., Mnatsakanyan V.A., Shashkov A.S., Agababyan P.V., 1999. Phenylpropanoid glycosides of teucrium polium. Chem Nat Comp. 27, 90-95.
88. Abrurjari T., Hadaib M., Cavrini V., 2008. Composition of the essential oil from Jordanian germander (Teucvium poliuml). Journal of Eessential Oil Research. 18, 97-99.
89. Ansari M., Alizadeh A.M., Paknejad M., Khaniki M., Naeimi S.M., 2009. Effects of Teucrium Polium honey on burn wound healing process. J Babol Uni Med Sci. 11, 7-12.
90. Capasso F., Cerri R., Morrica P., Senator F., 1983. Chemical composition and anti-inflammatory activity of an alcoholic extract of teucrium polium. Boll Soc Ital Biol Sper. 59, 1639-1643.
91. Tarig M., Ageel A., Al-Yahya M.A., Mossa J.S., al Said M.S., 1989. Anti-inflammatory activity of teucrium polium. Int J Tissue React. 11, 185-188.
92. Feisst C., Franke L., Appendino G., Werz O., 2005. Identification of molecular targets of the oligomeric nonprenylated acylphlorolucinols from Myrtus communis and their implication as anti-inflammatory compounds. J Pharmacol Exp Ther. 315(1), 389-96.
93. Domaracky M., Rehak P., Juhas S., Koppel J., 2007. Effects of selected plant essential oils on the growth and development of mouse preimplantation embryos in vitro. Physiol Res. 56(1), 97-104.
94. Burt S.A., Reinders R.D., 2003. Antibacterial activity of selected plant essential oils against Escherichia coli O157: H7. Lett Appl Microbial. 36(3), 162-6.
95. Gálvez M., Martín-Cordero C., López-Lázaro M., Cortés F., Ayuso M.J., 2003. Cytotoxic effect of plantago spp. On cancer cell lines. J Ethnopharmacol. 88(2-3), 125-30.
96. Mehrabian S., Majd A., Dana A., 2009 Antimutagenic and anticarcinogenic effect of vegetative and generative parts of Plantago major l. In langrood (gilan) and hesarak (karaj) areas. Q J Biol Sci. 1(2), 23-31.
97. Sharma R.A., Singh B., Singh D., Chandrawat P., 2009 Ethnomedicinal, pharmacological properties and chemistry of some medicinal plants of Boraginaceae in India. J Med Plant Res. 3(13), 153-75.
98. Shen C.C., Syu W.J., Li S.Y., Lin C.H., Lee G.H., Sun C.M., 2002. Antimicrobial activities of naphthazarins from Arnebia euchroma. J Nat Prod. 65(12), 1857-62.
99. Papageorgiou V.P, Assimopoulou A.N, Couladouros E.A., Hepworth D., Nicolaou K.C., 1999. The chemistry and biology of alkannin, shikonin and related naphthazarin natural products. Angew Chem. 38(3), 270-301.
100. Kaith B.S., Kaith N.S., Chauhan N.S.,1996Anti-inflammatory effect of Arnebia euchroma root extracts in rats. J Ethnopharmacol. 55(1), 77-80.
101. Azadbakht M., Semnani K., Khansari N., 2003. The Essential Oils Composition of Achillea Wilhelmsii C. Koch Leaves and Flowers. J Med Plan. 2, 55-59.
102. Csupor-Löffler B., Hajdú Z., Zupkó I., Réthy B., Falkay G., Forgo P., 2009. Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines. Phytother Res. 23(5), 672-6.
103. Abolhasani A., Bathaie S.Z., Yavari I., Moosavimovahedi A.A., Ghaffari M., 2005. Separation and Purification of Some Components of Iranian Saffron. Asian J Chem. 17(2), 727- 729.
104. Ernst E., 1999. Is garlic an effective treatment for Helicobacter pylori infection? Arch Intern Med. 8, 159(20), 2484-5
105. Sivam G.P., Lampe J.W., Ulness B.,1997. Helicobater pylori--invitro susceptibility to garlic (Allium sativum) extract. Nutr Cancer. 27(2), 118-21.
106. Rostaei M., Fallah S., Lorigooini Z., Surki A.A., 2018. The effect of organic manure and chemical fertilizer on essential oil, chemical compositions and antioxidant activity of dill (Anethum graveolens) in sole and intercropped with soybean (Glycine max). J Clean Prod. 199, 18-26.
107. Fallah S., Rostaei M., Lorigooini Z., Surki A.A., 2018. Chemical compositions of essential oil and antioxidant activity of dragonhead (Dracocephalum moldavica) in sole crop and dragonhead-soybean (Glycine max) intercropping system under organic manure and chemical fertilizers. Ind Crops Prod. 115, 158-65.
108. Behruzian A., Hosseinzadeh Samani B., Rostami S., Lorigooini Z., Behruzian M., 2018. The effect of combined AC electric field and ultrasound on the chemical compositions and Escherichia coli content of spearmint aromatic water. J Food Proc Eng. 41(2), 12650.
109. Karimi M., Parsaei P., Shafiei‐Alavijeh S, Rafieian‐Kopaei M, Yazdan Asadi S., 2016. Effect of silymarin alcoholic extract on surgery‐induced intraperitoneal adhesion in rats. Surg Prac. 20, 27-33.
110. Lavasanijou M.R., Sohrabi H.R., Karimi M., Ashjazade M.A., Salajeghe M., Farzineejadizadeh H., Parsaei P., Elmamooz A., 2012. Wound Healing Effects of Quercus Brantii and Pelargonium Graveolens Extracts in Male Wistar Rats. Wounds. 28(10), 369-375.
111. Ezzati S., Asadi S.Y., Parsaei P., Rafieian-kopaei M., 2015. Effect of hydroalcoholic extract of Rosa damascena on post-laparotomy intra-abdominal adhesions in rat. Sci J Kurdistan Uni Med Sci. 73-84.
112. Parsaei P., Karimi M., Asadi S.Y., Rafieian-Kopaei M., 2013. Bioactive components and preventive effect of green tea (Camellia sinensis) extract on post-laparotomy intra-abdominal adhesion in rats. Int J Surg. 11(9), 811-815.
113. Sedighi M., Sewell R.D.E, Nazari A., Abbaszadeh S., Cheraghi M., Amini A., Heydari Z., Rafieian-Kopaei M., 2019. A review on the most important medicinal plants effective in cardiac ischemia-reperfusion injury. Current Pharmaceutical Design. 25(3), 352-358.
114. Asadi S.Y., Parsaei P., Karimi K., Ezzati S., Zamiri A., 2013. Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat. Int J Surgery. 11(4), 332-337.
115. Gholami-Ahangaran M., Ostadpoor M., Heidari S.H., 2020. An Overview of Cinnamon Properties Effects on Blood Glucose and Hemoglobin A1C in Diabetic People. Plant Biotechnol Persa. 2(2), 33-37.
116. Karimi M., Parsaei P., Asadi S.Y., Ezzati S., 2013. Effectsof Camellia sinensis ethanolic extract on histometric and histopathological healing process of burn wound in rat. Middle East J Sci Res. 13(1), 14-19.
117. Abbaszadeh S., Andevari A.N., Koohpayeh A., Naghdi N., Alizadeh M., Beyranvand F., Harsej Z., 2018. Folklore medicinal plants used in liver disease: A review. Int J Green Pharmacy. 12(3), 463-472.
118. Solati K., Karimi M., Rafieian-Kopaei M., Abbasi N., Abbaszadeh S., Bahmani M., 2020. Phytotherapy for wound healing: The most important herbal plants in wound healing based on iranian ethnobotanical documents. Mini-Reviews Med Chem. 21(4), 500-519.
119. Abbasi N., Khalighi Z., Eftekhari Z., Bahmani M., 2020. Extraction and phytoanalysis of chemical compounds of Eucalyptus globulus leaf native to Dehloran, Ilam province, Iran by HS-SPME and GC-MS. Adv Animal Vet Sci. 8(6), 647-652.
120. Aidy A., Karimi E., Ghaneialvar H., Mohammadpour S., Abbasi N., 2020. Protective effect of Nectaroscordum tripedale extract and its bioactive component tetramethylpyrazine against acetaminophen-induced hepatotoxicity in rats. Adv Trad Med. 20(3), 471-477.
121. Abbasi N., Khosravi A., Aidy A., Shafiei M., 2016. Biphasic response to luteolin in MG-63 osteoblast-like cells under high glucose-induced oxidative stress. Iranian J Med Sci. 41(2), 118-125.
122. Karimi E., Abbasi S., Abbasi N., 2019. Thymol polymeric nanoparticle synthesis and its effects on the toxicity of high glucose on OEC cells: Involvement of growth factors and integrin-linked kinase. Drug Design Develop Therapy, 13, 2513-2532.
123. Karimipour M., Zareei L., Sabouri E., 2007. Effects of L-arginine on percentage of healing in burns in rats. Sci J Kurdistan Uni Med Sci. 12, 38-45.
120.
124. Ghorbani Ranjbary A., Varzandian S., Zarei A., Asmarian S., Jouibar F., 2014. Investigation of Hydralcoholic Extract of Silybum Marianum on Open Wound Healing in Mice. J Babol University Med Sci. 16(5), 35-41.