Green synthesis and study of antioxidant activity of indole derivatives using multicomponent reaction of 2,4-diaminoacetophenone

Subject Areas : Iranian Journal of Organic Chemistry

Parvaneh Firoozi-khanghah ¹ , Nafiseh Tabarsaei ² , Morad Avarsaji ³

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Received: 2022-12-21 Accepted : 2022-12-21 Published : 2022-08-01

Keywords: Water, 2, Three-component reaction, Isopropenylacetylene, 4-diamino acetophenone,

Abstract :

An efficient procedure for the synthesis of indole derivatives employing 2,4-diamino acetophenone, isopropenylacetylene and activated acetylenic compounds in the presence of KF/CP NPs as a heterogeneous base nanocatalyst in water at 80 oC is investigated. Also, the antioxidant activity of some synthesized compounds was studied. The workup of reaction is simple and the products can be separated easily from the reaction mixture. KF/CP NPs show a good improvement in the yield of the product. The catalyst displayed significant reusable activity.