Novel procedure for preparation of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition

Subject Areas :

Ali Ezabadi ¹ , Fatemeh Tosan ²

1 - Department of Chemistry, Faculty of Sciences, Islamic Azad University, Central Tehran Branch, Sanat Square, Iran
2 - Department of Chemistry, Faculty of Sciences, Islamic Azad University, Central Tehran Branch, Sanat Square, Iran

Received: 2015-07-10 Accepted : 2015-10-10 Published : 2015-12-01

Keywords: Hantzsch 1, 4 – dihydropyridines, PEG-400, Three-component reaction, catalyst-free, Aldehydes, ethyl acetoacetate, ammonium acetate,

Abstract :

An efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at 110°С and the products were obtained in good to high yields.

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