A new pyrrolidinyl-piperazine alkaloid derivative from Oxyanthus speciosus DC. (Rubiaceae)

Subject Areas : Phytochemistry: Isolation, Purification, Characterization

Judith Caroline Ngo Nyobe ¹ , Désiré Mama Bikélé ² , Matiedjie Becky Fodouop ³ , Emmanuel Mpondo Mpondo ⁴ , Jean Claude Ndom ⁵

1 - Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon
2 - Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon
3 - Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon
4 - Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, P.O. Box 24157, Douala, Cameroon
5 - Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon

Received: 2019-12-18 Accepted : 2020-07-08 Published : 2020-09-01

Keywords: 2-(7'-methylhexyloxy)-furan-5'-yl6-(pyrrolidin-7-yl)piperazine, Oxyanthus speciosus DC, Rubiaceae, Anti-inflammatory activity,

Abstract :

A new pyrrolidinyl-piperazine alkaloid derivative named 2-(7’-methylhexyloxy)furan-5’-yl)-6- (pyrrolidin-7-yl)piperazine (1), along with five known compounds were isolated from methanolic extract of the roots of Oxyanthus speciosus DC. (Rubiaceae). The structure of this new alkaloid was elucidated on the basis of the relevant NMR and MS analyses. Compound (1) possesses potent in vitro anti-inflammatory activity by protein denaturation assay with an IC50 value of 1.930 ± 0.9123 µg/mL. The obtained results indicated that the crude methanolic extract of O. speciosus DC. roots and its isolated pyrrolidinyl-piperazine alkaloid have potentials for further development as an effective and natural anti-inflammatory agents.

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