مروری بر تشکیل بیوفیلم و کوروم سنسینگ در باکتری سودوموناس آئروژینوزا
محورهای موضوعی : فصلنامه کیفیت و ماندگاری تولیدات کشاورزی و مواد غذاییراضیه بهزادمهر 1 , مریم بیگمی 2 , سعیده سعیدی 3
1 - دانشیار، گروه رادیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی زابل، زابل، ایران
2 - استادیار، گروه صنایع غذایی، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران
3 - کارشناسی ارشد، پژوهشکده زیست‌فناوری کشاورزی، دانشگاه زابل، زابل، ایران
کلید واژه: کوروم سنسینگ, بیوفیلم, سودوموناس آئروژینوزا, عصاره گیاه,
چکیده مقاله :
چکیده:سودوموناس آئروژینوزایک پاتوژن فرصت طلب و عامل10الی15درصد از عفونت های بیمارستانی میباشـد.وجـود ژن هـایحدت یکی از مهمترین مکانیسم های تهاجمی سودوموناس آئروژینوزامیباشد و این موضوع از نظر پزشـکی از اهمیـت ویـژه ای برخـورداراست.بیان بسیاری از ژن های بیماریزای باکتری سودوموناس آئروژینوزابه وسیله یک سیستم ژنی بـه نـام سیسـتمQuorum Sensing(QS)کنترل و تنظیم میگردند. کروم سنسینگ سیستم ارتباطی سلول به سلول با استفاده از مولکولهـای کوچـکSMsدر ارگانیسـم های تک سلولی است.هدف از تحقیق بررسی تشکیل بیوفیلم در سیستم کروم سنسـینگ در سـویه هـایسـودوموناس آئروژینـوزامیباشد.مطالعه مروری حاضر با کمک مقالات نمایهشده درپایگاههای علمی فارسی Magiran و SID وپایگاههای علمی انگلیسی Scopus، Google scholar، Ebscohostو Science Directبدست آمد.ژنهای سیستم QSفراوانی بالایی در بین سویه های سودوموناس آئروژینوزاجداشده از منابع انسانی دارند.همچنین این باکتری بعنوان یک باکتری عفونت زابا مقاومت آنتی بیوتیکی بالا میباشد.نتایج مطالعه نشان داد که گیاهان دارویی در رقت های مختلف مهار کننده کوروم سنسینگ و بیوفیلم در باکتری ها می باشند.
Pseudomonas aeruginosa is an opportunistic pathogen and causes 10 to 15% of nosocomial infections. The presence of unity genes is one of the most important invasive mechanisms of Pseudomonas aeruginosa and this issue is of special medical importance.The expression of many Pseudomonas aeruginosa pathogenic genes is controlled by a gene system called the Quorum Sensing System (QS). Chromosensing is a cell-to-cell communication system using small SMs molecules in single-celled organisms. The present review study was obtained with the help of articles indexed in Magiran and SID Persian scientific databases and Scopus, Google scholar, Ebscohost and Science Direct English databases.The QS system genes are highly abundant among human-derived Pseudomonas aeruginosa strains. It is also known as an infectious bacterium with high antibiotic resistance.The results showed that medicinal plants in different dilutions inhibit chromosome sensing and biofilm in bacteria.The results showed that medicinal plants in different dilutions inhibit chromosome sensing and biofilm in bacteria.
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