مطالعه برون‌تنی نانوذرات GdF3:Bi سنتز شده به روش هیدروترمال به عنوان ماده حاجب دوگانه (MRI-CT)
محورهای موضوعی : بیومواد
محمد عباسی
1
(
گروه مهندسی مواد دانشگاه بین المللی امام خمینی (ره)
)
رضا احمدی
2
(
گروه مهندسی مواد، دانشکده فنی و معندسی، دانشگاه بین الملل امام خمینی (ره)، قزوین، ایران
)
امیرحسین مغنیان
3
(
مهندسی و علم مواد، دانشکده فنی مهندسی، دانشگاه بین المللی امام خمینی (ره)، قزوین
)
اعظم جنتی اصفهانی
4
(
دانشگاه علوم پزشکی قزوین
)
کلید واژه: نانوذرات مغناطیسی, پلی اتیلن گلیکول, سورفکتانت, MRI, CT Scan,
چکیده مقاله :
در این پژوهش نانوذرات گادلنیوم فلوراید (GdF3) دوپ شده با بیسموت (Bi) به روش هیدروترمال سنتز شد و تاثیر دما و مدت زمان فرآیند و همچنین غلظت NH4F (تنظیم کننده pH) مطالعه شد. برای این منظور از پلی اتیلن گلیکول به عنوان سورفکتانت در فرآیند سنتز نانوذرات GdF3:Bi استفاده شد. شناسایی فازها با طیف‌سنجی پراش اشعه ایکس (XRD)، تصویربرداری میکروسکوپی با میکروسکوپ الکترونی روبشی گسیل میدانی (FE-SEM) و آنالیز عنصری با طیف‌سنجی پراش انرژی اشعه ایکس (EDS) انجام گرفت. بررسی خواص کنتراست‌زایی نمونه‌ی مطلوب از طریق تصویربرداری رزونانس مغناطیسی (MRI) و توموگرافی کامپیوتری (CT) در شرایط برون‌تنی انجام گرفت. نمونه‌ی تولید شده در دمای °C180، طی مدت زمان 6 ساعت و با غلظت دو برابر ضریب استوکیومتری NH4F با داشتن مورفولوژی مکعبی، اندازه ذرات کمتر از nm 100 و یکنواختی توزیع عناصر مطلوب‌ترین نمونه بوده و بررسی کنتراست‌زایی در حالت برون‌تنی نشان داد که این نانوذرات در تصویربرداری CT یک کنتراست‌زای مثبت عالی است و در تصاویر MRI نیز غلظت‌های 5/22 تا 180 میلی مولار آن کنتراست بالایی ایجاد می‌کند. به طور خلاصه می‌توان نتیجه گرفت، دوپ کردن Bi با GdF3 موفقیت‌آمیز بوده است و می‌توان از این نانوذرات به عنوان یک ماده حاجب در تصویربرداری دوگانه MRI-CT استفاده کرد.
In the present study, the Bismuth doped GdF3 nanoparticles were synthesized via the hydrothermal method and the effect of temperature, time and NH4F concentration was investigated. The Poly Ethylene Glycol was used as the surfactant. The phases characterization was inducted via XRD, FE-SEM and EDS techniques. The in vitro investigation of the samples as the contast agents were performed using MR and CT imaging. the sample synthesized at 180 oC,, 6 hours and the NH4F concentration twice the Stoichiometric concentration that had the semi spherical structure with mean size lower than 100 nm was the suitable sample and the in vitro studies show that the particles act as an excellent CT contrast agent and also as an effective MRI contrast agent at concentrations between 22.5 and 180 mM. Briefly, The use of Bismuth dopant ant GdF3 nanoparticles was successfully performed and The particles can used as the potential MRI-CT contrast agents.
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