فهرست مقالات Thioridazine

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  1 - Electrochemical Determination of Thioridazine at Carbon Ionic Liquid Electrode
  Mahzad Sakiani Abulhasan Fatemeh Farjami
  In this manuscript a simple, rapid, and sensitive electrochemical method for the direct determination of thioridazine (TR) was developed. The electrochemical behavior of TR was studied at carbon ionic liquid electrode (CILE). The cyclic voltammetric results showed that چکیده کامل

  In this manuscript a simple, rapid, and sensitive electrochemical method for the direct determination of thioridazine (TR) was developed. The electrochemical behavior of TR was studied at carbon ionic liquid electrode (CILE). The cyclic voltammetric results showed that CILE remarkably improved electrocatalytic activity towards the oxidation of TR in slightly acidic solutions. It led to a significant enhancement of the anodic peak current for TR with three anodic peaks at 0.59V, 0.78V and 0.93V, respectively and could effectively accumulate the drug at the electrode surface. The electrocatalytic performance was further exploited as a sensitive detection scheme for the determination of TR by differential-pulse voltammetry (DPV). Under optimized conditions, the calibration linear range and detection limit were 0.25 to 100 𝜇M and 50 nM, respectively. The proposed method was successfully used to quantification of TR in pharmaceutical samples. Also the analytical performance of this sensor has been evaluated for detection of TR in human serum samples. پرونده مقاله
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  2 - Voltammetric Investigation of Thioridazine Using a Carbon Nanocomposite Electrode in Human Biological Samples
  Elham Eslami Fatemeh Farjami
  An electrochemical method employing a carbon nanocomposite electrode was developed to measure thioridazine. The electrode has been designed by incorporation of montmorillonite nanoclay into the carbon ionic liquid electrode. Surface morphology of the electrodes was d چکیده کامل

  An electrochemical method employing a carbon nanocomposite electrode was developed to measure thioridazine. The electrode has been designed by incorporation of montmorillonite nanoclay into the carbon ionic liquid electrode. Surface morphology of the electrodes was done using scanning electron microscopy. Adsorptive stripping voltammetry was applied as a very sensitive analytical method for the determination of sub-micromolar amounts of thioridazine. The optimized linear working range and detection limit (S/N=3) are 0.1-50 μM and 21nM, respectively. The nanocomposite electrode demonstrates several advantages such as simple preparation method, excellent activity in physiological conditions, low detection limit, long-term stability, and remarkable voltammetric reproducibility. As a result, it can find promising applications in blood serum and urine samples. پرونده مقاله