فهرست مقالات Spermacoce radiata

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  1 - Combined ethanol extract of Spermacoce radiata and Hypselodelphyspoggeana prevents renal damage and dyslipidemia in benign prostatic hyperplasia induced rats
  رابرت اورکو پوول آنیام امانوئل اویو اوبینا آجا
  10.30495/medherb.2021.688096
  Background & Aim: A combined ethanol extract of Spermacoce radiata and Hypselodelphyspoggeana leaves are used for the treatment of benign prostatic hyperplasia, but there is no scientific data on its safety level and effects on vital organs and biochemical parameter چکیده کامل

  Background & Aim: A combined ethanol extract of Spermacoce radiata and Hypselodelphyspoggeana leaves are used for the treatment of benign prostatic hyperplasia, but there is no scientific data on its safety level and effects on vital organs and biochemical parameters. This study investigated the effects of a combined ethanol extract of Spermacoce radiata and Hypselodelphyspoggeana leaves (CESHL) on the lipid profile and kidney function of benign prostatic hyperplasia (BPH) induced rats.Experimental: A total of 21 rats were used for the acute toxicity study, while 30 were randomly distributed into five groups comprising six rats each (n = 6) for the BPH study. Group 1 served as normal control, while group 2 was BPH control that received 5 mg/kg of testosterone propionate/day for 28 consecutive days without treatment. Groups 3 – 5 received 5 mg/kg of testosterone propionate/day for 28 days but after an hour, they treated with 5 mg/kg of finasteride, 200 and 600mg/kg of CESHL/day, respectively, for 28 days.Results: The acute toxicity result of CESHL indicated no mortality or any sign of toxicity. Administration of the extract caused a significant reduction (p<0.05) of theprostate weight, triacylglycerol, cholesterol, low-density lipoprotein (LDL-C), urea and creatinine concentrations in the treated groups when compared to the BPH control. A significant increase (P<0.05) in High-Density Lipoprotein (HDL) concentration was observed in all treated groups when compared to the BPH control group. Histological outcomes of rats’ kidneys corroborated these findings.Recommended applications/industries: These results indicate that the combined extracts possess antilipidemic and nephroprotective effects, which might help in the management of complications that might arise during BPH. پرونده مقاله
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  2 - Evaluation of phytochemicals, antioxidant contents and in vitro antioxidant activities of a combined ethanol extract of Spermacoce radiata and Hypselodelphys poggeana leaves
  رابرت اوروکو چیندو آگووامبا چینومسو آرون پوئل نیوجی-آنیالوو مرسیلین اوچه
  10.30495/medherb.2022.698466
  Background & Aim: Oxidative stress causes lipid peroxidation, damages various macromolecules, tissues and organs, and is involved in the pathogenesis of several diseases. Antioxidant supplementation could help scavenge free radicals and prevent oxidative stress. Thi چکیده کامل

  Background & Aim: Oxidative stress causes lipid peroxidation, damages various macromolecules, tissues and organs, and is involved in the pathogenesis of several diseases. Antioxidant supplementation could help scavenge free radicals and prevent oxidative stress. This study evaluated the phytochemicals, antioxidant compositions and in vitro antioxidant activities of a combined extract of Spermacoce radiata and Hypselodelphy spoggeana leaves (CEESH).Experimental: This study determined phytochemicals and antioxidant vitamins contained in CEESH. The in vitro antioxidant activities of CEESH comprising DPPH (1,1-diphenyl-2-picrylhydrazyl), nitric oxide, ferric reducing antioxidant power (FRAP), total antioxidant capacity (TAC) and thiobarbituric acid reactive substances (TBARS) were assayed.Results: The phytochemical results indicated substantial amounts of total phenols, alkaloids, and terpenoids, along with moderate amounts of tannins, flavonoids, and steroids in CEESH with a low glycoside concentration, but saponin was not detected. The plant extract also showed substantial concentrations of vitamins A, C, and E.The DPPH, nitric oxide, FRAP, TAC and TBARS for the CEESH indicated that the extract has substantial free radical scavenging activities. The CEESH demonstrated a dose-dependent significant increase in the nitric oxide, TAC, and TBARS scavenging activities, while the CEESH showed dose-dependent marked increase in FRAP within a concentration range of 40–640 µg/mL. The half-optimal effective concentration (EC50) values of the CEESH for DPPH, nitric oxide, and TBARS were 7.23, 39.40, and 63.41 µg/mL, respectively.Recommended applications/industries: These findings suggest that CEESH contains abundant phytochemicals and antioxidant vitamins and possesses high free radical scavenging potential. Therefore, CEESH could be a viable therapeutic agent for managing oxidative stress. پرونده مقاله