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دسترسی آزاد مقاله
1 - Design, Characterization and Application of N1,N1,N2,N2-Tetramethyl-N1,N2-bis(sulfo)ethane-1,2-diaminium Trifluoroacetate as a Novel Ionic-Liquid Catalyst for the Production of Polyhydroquinolines
Zahra Kordrostami Abdolkarim ZareA novel Brønsted acidic ionic liquid namely N1,N1,N2,N2-tetramethyl-N1,N2-bis(sulfo)ethane-1,2-diaminium trifluoroacetate {[TMBSED][TFA]2} was synthesized, and characterized by studying its1H NMR, 13C NMR, 19F NMR and mass spectral data. Afterward, the ionic liqu چکیده کاملA novel Brønsted acidic ionic liquid namely N1,N1,N2,N2-tetramethyl-N1,N2-bis(sulfo)ethane-1,2-diaminium trifluoroacetate {[TMBSED][TFA]2} was synthesized, and characterized by studying its1H NMR, 13C NMR, 19F NMR and mass spectral data. Afterward, the ionic liquid was applied ascatalyst for the production of polyhydroquinoline derivatives via the one-pot multi-componentreaction of arylaldehydes with dimedone, β-ketoesters and ammonium acetate under solvent-freeconditions. The protocol had several advantages, which include: (i) efficiency, (ii) generality, (iii)excellent yields of the products, (iv) short reaction times, (v) clean reaction profile, (vi) simplicity,(vii) usage of a few amount of the catalyst, (viii) easy preparation the catalyst from available andinexpensive starting materials, (ix) mild reaction conditions, (x) performing the reaction in solventfreeconditions, and (xi) easy work-up. پرونده مقاله -
دسترسی آزاد مقاله
2 - One –Pot Synthesis of Polyhydroquinoline Derivatives via Hantzsch Condensation Reaction Using Nanosized Magnesium Oxide as Heterogeneous Catalyst
Hakimeh Mirzaee Ahmad Izadyar Abolghsem Davoodnia Hoseyn EshghiAn efficient, recyclable and environmental-friendly synthetic route to polyhdroquinoline derivatives have been developed via multi-component one-pot Hantzsch reaction of various aromatic aldehyde, 2 equivalents of 5,5-dimethyl-1,3-cyclohexanedione (dimedone), ethyl acet چکیده کاملAn efficient, recyclable and environmental-friendly synthetic route to polyhdroquinoline derivatives have been developed via multi-component one-pot Hantzsch reaction of various aromatic aldehyde, 2 equivalents of 5,5-dimethyl-1,3-cyclohexanedione (dimedone), ethyl acetoacetate and ammonium acetate using nano magnesium oxide as a catalyst in ethanol under reflux condition. Reaction with 4-chlorobenzaldehyde was selected as the model reaction and different conditions for temperature, amount of catalyst and kind of solvent have been studied on it. It was found that 0.03 g catalyst in reflux condition and ethanol as solvent is the optimum condition which resulted in 94% yield. The present approach offers several advantages such as short reaction times, easy isolation and purification of product, and safe, non-toxic, recyclable and economic use of catalyst. پرونده مقاله -
دسترسی آزاد مقاله
3 - P2O5/Al2O3 as an effieientcatalystfor one-potsynthesis of polyhydroquinoline derivativesundersolvent-free conditions
Tayebeh Sanaeishoar Sara RoueenThe condensation of aromatic aldehydes, dimedone, ethylacetoacetate and ammonium acetate promoted by was Phosphorus pentoxide supported on alumina carried out under solvent-free conditions to afford corresponding polyhydroquinolinederivatives. This method provides sever چکیده کاملThe condensation of aromatic aldehydes, dimedone, ethylacetoacetate and ammonium acetate promoted by was Phosphorus pentoxide supported on alumina carried out under solvent-free conditions to afford corresponding polyhydroquinolinederivatives. This method provides several advantages including highyields, low reaction times, easy work up and little catalyst loading. پرونده مقاله -
دسترسی آزاد مقاله
4 - P2O5/Al2O3 as an effieient catalyst for one-pot synthesis of polyhydroquinoline derivatives under solvent-free conditions
Tayebeh Sanaeishoar Sara RoueenThe condensation of aromatic aldehydes, dimedone, ethylacetoacetate and ammonium acetate promoted by was Phosphorus pentoxide supported on alumina carried out under solvent-free conditions to afford corresponding polyhydroquinolinederivatives. This method provides sever چکیده کاملThe condensation of aromatic aldehydes, dimedone, ethylacetoacetate and ammonium acetate promoted by was Phosphorus pentoxide supported on alumina carried out under solvent-free conditions to afford corresponding polyhydroquinolinederivatives. This method provides several advantages including high yields, low reaction times, easy work up and little catalyst loading. پرونده مقاله -
دسترسی آزاد مقاله
5 - Co3O4 nanoparticles as a robust and recoverable catalyst for one-pot synthesis of polyhydroquinolines and tetrahydrobenzopyrans
Mohammad Ali Ghasemzadeh Zahra ElyasiThis study introduces a green and efficient method for preparation of biologically-active substituted 4H-pyrans using the one-pot three-component reaction of aromatic aldehydes, dimedone and malononitrile in the presence of cobalt oxide nanoparticles. Co3O4 nanoparticle چکیده کاملThis study introduces a green and efficient method for preparation of biologically-active substituted 4H-pyrans using the one-pot three-component reaction of aromatic aldehydes, dimedone and malononitrile in the presence of cobalt oxide nanoparticles. Co3O4 nanoparticles were used as an efficient catalyst for the synthesis of polyhydroquinoline derivatives by the reaction of aromatic aldehydes, ethyl acetoacetate, dimedone and ammonium acetate. The preparation and use of Co3O4 as a powerful and reusable nanocatalyst under solvent-free conditions is described. The catalyst was characterized by spectral techniques including XRD, FE-SEM, FT-IR, VSM, EDX and TEM analysis. This method offers the advantages of high yield, short reaction time, comfortable work-up and reusability of the catalyst. پرونده مقاله -
دسترسی آزاد مقاله
6 - Highly efficient one-pot four-component synthesis of polyhydroquinoline derivatives catalyzed by stannous chloride under solvent-free conditions
Surekha Deshmukh Jitendra Gujar Ramrao Mane Murlidhar ShingareA rapid and efficient one-pot, four-component protocol towards the synthesis of polyhydroquinoline derivatives has been developed. The condensation of aldehyde, dimedone, ethyl acetoacetate and ammonium acetate in presence of stannous chloride was carried out under solv چکیده کاملA rapid and efficient one-pot, four-component protocol towards the synthesis of polyhydroquinoline derivatives has been developed. The condensation of aldehyde, dimedone, ethyl acetoacetate and ammonium acetate in presence of stannous chloride was carried out under solvent free condition to synthesize a variety of polyhydroquinoline derivatives in good to excellent yields. Stannous chloride was proved to be an efficient heterogeneous Lewis acid catalyst, which could be relatively non-toxic, inexpensive, possess good thermal stability and easy to handle. The present method provides several advantages such as mild reaction conditions, green methodology, inexpensive catalyst, simple work-up procedure, short reaction time and high yields. پرونده مقاله -
دسترسی آزاد مقاله
7 - SFHS: Reusable catalyst for the synthesis of polyhydroquinoline derivatives and its molecular docking studies against tyrosine protein kinase
Amit Waghmare Tushar Patil Kailash Kadam Shivaji PanditAn efficient synthesis of polyhydroquinoline derivatives is achieved via Hantzsch condensation reaction between aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of catalytic amount of SFHS in ethanol. This method gives remarkable advantages s چکیده کاملAn efficient synthesis of polyhydroquinoline derivatives is achieved via Hantzsch condensation reaction between aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of catalytic amount of SFHS in ethanol. This method gives remarkable advantages such as shorter reaction time, simple workup procedure and good to excellent yields. Furthermore the catalyst can be recovered conveniently and reused efficiently. To analyze potential anticancer activity, synthesized derivatives were docked to tyrosine protein kinase (1YJ) against 4ST and PTR binding sites. پرونده مقاله -
دسترسی آزاد مقاله
8 - 1,3-Dibromo-5,5-dimethylhydantoin (DBH) as a cheap and efficient catalyst for the synthesis of polyhydroquinolines and 12-aryl-8,9,10,12-tetrahydro [a] xanthene-11-ones
Farhad Shirini Gholam Hossein Imanzadeh Masoumeh Abedini Parisa Ghods Ghasemabadi1,3-Dibromo-5,5-dimethylhydantoin (DBH), as a cheap and commercially available reagent, is efficiently able to catalyze the synthesis of polyhydroquinoline derivatives and 12-aryl-8,9,10,12-tetrahydro[a] xanthene-11-ones via one-pot multi-component reactions. This novel چکیده کامل1,3-Dibromo-5,5-dimethylhydantoin (DBH), as a cheap and commercially available reagent, is efficiently able to catalyze the synthesis of polyhydroquinoline derivatives and 12-aryl-8,9,10,12-tetrahydro[a] xanthene-11-ones via one-pot multi-component reactions. This novel synthetic method has the advantages of low cost and availability of the catalyst, short reaction times, high to excellent yields, simple and easy work-up and purification of the products compared to the conventional methods reported in the literature. پرونده مقاله