فهرست مقالات Malvaceae

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  1 - Molecular docking, anti-inflammatory, antimicrobial and antioxidant evaluation of <i>Pterospermum rubiginosum</i> B. Heyne
  Rajamohanan Anish Fathima Rumaisa Thankamani Aswathy Velappan Nair Kalpana Arun Rauf
  10.30495/tpr.2023.1977515.1316
  Pterospermum rubiginosum B.Heyne ex G.Don (PR) is a traditional medicinal plant used by the tribal people of the Western Ghats to treat bone fractures, inflammation, and sprain. Being an under-explored medicinal plant, the mechanism behind the anti-inflammatory activity چکیده کامل

  Pterospermum rubiginosum B.Heyne ex G.Don (PR) is a traditional medicinal plant used by the tribal people of the Western Ghats to treat bone fractures, inflammation, and sprain. Being an under-explored medicinal plant, the mechanism behind the anti-inflammatory activity of PR is unknown to the scientific community. FTIR analysis was done to recognize the functional groups in PR bark extract, and LCMS elucidated the phytochemical characterization. Molecular docking studies showed an excellent ligand and protein (inflammatory mediators) binding and their interactive mechanism. Total phenolic and total flavonoid contents were found to be 46.7 and 37.4 g/100 g for PRME. PRME showed hydrogen peroxide and DPPH (1,1diphenyl-2-picryl hydrazyl) radical scavenging activity with IC50 values of 48.33 and 42.70 &micro;g/mL, respectively. Gene expression study of COX-1 and COX-2 enzymes confirmed the anti-inflammatory activity of PRME. The present study justifies the potential use of PR in the traditional medicine as an anti-inflammatory agent. پرونده مقاله
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  2 - Unlocking the anthelmintic potential of <i>Grewia bilamellata</i> Gagnep.: <i>In-vitro</i> and molecular docking studies on adult Indian earthworms
  Poornima Gurivelli Sunitha Katta
  10.30495/tpr.2023.1983640.1332
  Anthelmintic resistance remains a significant challenge for the treatment of gastrointestinal parasites. The search for novel compounds is costly, but the traditional knowledge of Sashechalam hill practitioners led us to investigate Grewia bilamellata Gagnep. We assesse چکیده کامل

  Anthelmintic resistance remains a significant challenge for the treatment of gastrointestinal parasites. The search for novel compounds is costly, but the traditional knowledge of Sashechalam hill practitioners led us to investigate Grewia bilamellata Gagnep. We assessed its anthelmintic activity against Indian earthworms (Pheretima posthuma) using various extract concentrations (10, 20, 50, and 100 mg/mL), with albendazole as the positive control and normal saline as the negative control. The duration of paralysis and death indicated anthelmintic efficacy. G. bilamellata ethanol extract (GBEE) demonstrated a significant concentration-dependent effect. The IC50 values for albendazole, G. bilamellata petroleum ether extract (GBPE), G. bilamellata ethyl acetate extract (GBEA), and GBEE were 181.947, 310.337, 270.488, and 223.468 mg/mL, respectively. GBEE exhibited potent anthelmintic activity comparable to that of albendazole, with the lowest paralysis and death rates in the model. The HR-LC-MS analysis of GBEE identified 38 phytoconstituents, of which 22 compounds obeyed Lipinski&rsquo;s rule. Molecular docking with &beta;-tubulin revealed that 15 compounds exhibited superior binding energy (-8.3 to -6.3 kcal/mol) compared to albendazole (-6.1 kcal/mol). Further investigations are crucial to isolate and evaluate these compounds for the development of new anthelmintic drugs. Our findings support the traditional use of G. bilamellata Gagnep. as an anthelmintic, and highlight its potential for future therapeutic applications. پرونده مقاله