فهرست مقالات Imatinib

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  1 - Electrocatalytic Determination of Anti-Cancer Drug Imatinib, Using Ni Nanoparticle Modified Carbon Paste Electrode
  Fatemeh Khakpoor Shahla Fathi
  In this research, nickel nanoparticles were synthesized by non-aqueous polyol method and morphology of nanoparticles was studied using scanning electron microscopy. Then Ni nanoparticle modified carbon paste electrode was prepared. Electrochemical behavior of modified e چکیده کامل

  In this research, nickel nanoparticles were synthesized by non-aqueous polyol method and morphology of nanoparticles was studied using scanning electron microscopy. Then Ni nanoparticle modified carbon paste electrode was prepared. Electrochemical behavior of modified electrode was studied in basic solution, using cyclic voltammetry and chronoamperometry methods. A pair of oxidation-reduction peaks relating to Ni(OH)2/ NiOOH redox couple was observed in cyclic voltammogram of this electrode. Also, the electrochemical behavior of this electrode in presence of imatinib drug was studied. Results show that this modified electrode has a good ability for electrocatalytic oxidation of imatinib in basic solution. In presence of imatinib, current intensity of oxidation peak of electrode was increased, depending on its concentration. Linear dynamic range, limit of detection and rate constant of electrocatalytic reaction were determined using cyclic voltammetry and chronoamperometry methods. Amount of limit of detection (LOD) in cyclic voltammetry and hydrodynamic amperometry methods were calculated 1.2 × 10 -6 M and 3.5 × 10-7M respectively. Finally, the proposed sensor was successfully applied for determination of imatinibin real samples such as tablet and human blood plasma. پرونده مقاله
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  2 - Evaluation of antimicrobial effects of synthesized Zinc sulphide nanoparticles and their potentiation by the anticancer drug imatinib
  Bushra Issa Kayid Al-Zuabidi Mai Yaqoob Yousif Al-Marzooq Ahmed Naser Herez Al-Musawi
  Zinc sulphide (ZnS) nanoparticles were synthesized by simple aqueous chemical reaction of zinc chloride and sodium sulphide in an aqueous solution. The main advantage of ZnS nanoparticles of diameter 29 nm was that the sample could be prepared by using of cheap precurso چکیده کامل

  Zinc sulphide (ZnS) nanoparticles were synthesized by simple aqueous chemical reaction of zinc chloride and sodium sulphide in an aqueous solution. The main advantage of ZnS nanoparticles of diameter 29 nm was that the sample could be prepared by using of cheap precursors in a cost effective and eco-friendly manner. Structural, morphological and chemical composition of the prepared nanoparticles were investigated by X-Ray Diffraction(XRD),Scanning Electron Microscopy(SEM) with energy dispersion X-ray dispersive fluorescence spectroscopy (EDAX) and Fourier transform infrared (FTIR) spectroscopy. The antimicrobial effects of the zinc sulphide (ZnS) nanocrystals and the anticarcinogenic agent imatinib were studied by spot inoculation technique and also by well diffusion technique against twelve pathogenic bacterial strains. Nanoparticles of ZnS showed antimicrobial activity against both Gram positive and Gram negative strains except Shigella sonnei. The anticancer drug imatinib was inhibitory for only Gram positive organisms, Bacillus subtilis and Staphyloccus aureus. Synergism between imatinib and ZnS nanoparticles was distinctly observed in all the Gram positive strains. پرونده مقاله