فهرست مقالات Galectin-3

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  1 - Effect of a bout of heavy resistance training on galectin-3 in healthy young men
  Hamid Reza Nayeri khoob
  Introduction: Galectins are a family of carbohydrate-binding proteins with an affinity for beta-galactosides. Galectin-3 is a member of the galectin family and numerous previous studies have indicated that galectin-3 may be used as a diagnostic or prognostic biomarker f چکیده کامل

  Introduction: Galectins are a family of carbohydrate-binding proteins with an affinity for beta-galactosides. Galectin-3 is a member of the galectin family and numerous previous studies have indicated that galectin-3 may be used as a diagnostic or prognostic biomarker for certain types of heart disease, kidney disease and cancer. The aim of present study was to investigate the effect of a bout of heavy resistance training on galectin-3 in healthy young men. Material & Methods: Elevenhealthy young men (aged: 26.6 ± 1.5 years; ± SD) volunteered to participate in this study. One reparation maximum (1-RM) was measured and the subjects were performed a heavy resistance exercise trial consisted of eight exercises (chest press, triceps extension, latissimus pull down, shoulder press, arm curls, leg extension, leg curls, and curl-up) of 8 repetitions with 3 sets at 80% of 1RM. Blood samples were taken at baseline and immediately after the heavy resistance exercise trial. Results: The results showed that galectin-3 level was increased significantly in response to heavy resistance exercise trial (365.9±110.3 mg/dl vs. 390.6±117.7 mg/dl; P=0.012). No significant relationships were observed between galectin-3 levels after the intervention with cholesterol (P=0.16), triglycerides (P=0.29), LDL (P=0.34) or HDL (P=0.92). Conclusions: The results suggest a bout of heavy resistance training increases galectin-3 healthy young men. پرونده مقاله
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  2 - The relationships between Galectin-3 levels with cardiac structure and function in well- trained endurance athletes
  Ibrahim Radmehr
  Introduction: Clinical studies support a potential role of galectin-3 in the pathogenesis of remodelling in heart failure in humans; but these relationships in athletes are not well known. The present study was conducted to examine the relationships between galectin-3 l چکیده کامل

  Introduction: Clinical studies support a potential role of galectin-3 in the pathogenesis of remodelling in heart failure in humans; but these relationships in athletes are not well known. The present study was conducted to examine the relationships between galectin-3 levels with cardiac structure and function in well-trained endurance athletes. Material & Methods: Fifteen well-trained endurance male athletes (aged: 21.4 ± 3.0 years; mean ± SD) volunteered to participate in this study. Galectin-3 concentrations were assessed by enzyme-linked immunosorbent assay (ELISA) kits and cardiac morphology and function were assessed by echocardiography. Pearson correlation test was used to analyze the relationship between the variables. Results: The results demonstrated that galectin-3 concentrations positively related to aorta diameter (r = 0.61, P = 0.01) and negatively related to left ventricle end-diastolic volume (LVEDV) (r = ‒ 0.6, P = 0.01). No significant relationships were observed between galectin-3 concentrations with left ventricle ejection fraction (LVEF) (r= ‒ 0.08, P = 0.7), pulmonary artery diameter (r = 0.25, P = 0.3), posterior wall thickness of left ventricle at end diastole (PWTLV) (r = 0.37, P = 0.1), interventricular septal (r = 0.15, P = 0.5), and left ventricle end-systolic volume (LVESV) (r = 0.48, P = 0.07). Conclusions: In conclusion, galectin-3 concentrations are associated with echocardiographic markers of ventricular function in endurance athletes. پرونده مقاله
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  3 - Effect of 8 weeks regular endurance training on galectin-3 changes after a strenuous aerobic exercise
  Nooshin Khajeian Mehrzad Moghadasi
  Introduction: Galectin-3 (gal-3) is a member of the lectin family that is associate with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and ventricular remodeling. Although gal-3 increases after high intensity exercise, چکیده کامل

  Introduction: Galectin-3 (gal-3) is a member of the lectin family that is associate with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and ventricular remodeling. Although gal-3 increases after high intensity exercise, regular training may attenuate these conditions. The aim of present study was to investigate the effect of 8 weeks regular endurance training on galectin-3 changes after a strenuous aerobic exercise. Material & Methods: Elevenhealthy young men (aged: 20.8 ± 1.8 years; ± SD) volunteered to participate in this study. All the subjects were performed Repeated High-Intensity Endurance Test (RHIET) as a strenuous aerobic exercise. Thereafter, the subjects were performed endurance training 3 days a week for 8 weeks at an intensity corresponding to 60-75% individual heart rate reserve (HRR) for 30-45 min. After the 8 weeks intervention, the RHIET was performed a gain. Blood samples were taken at baseline (1st step), immediately after the RHIET (2nd step), 48h after 8 weeks intervention (3rd step) and immediately after the second RHIET (4th step). Results: The results showed that gal-3 level was increased after the first strenuous aerobic exercise (P<0.05). After 8 weeks exercise training, gal-3 was decreased compared to 2nd step of blood sampling (P<0.05) and no significant change was observed in gal-3 in this step compare to the baseline. The results indicated that gal-3 level was lower after the second strenuous aerobic exercise than compare to the after the first strenuous aerobic exercise (P<0.05). Conclusions: The results suggest regular endurance training with specific intensity and duration utilized in this study, attenuate gal-3 changes after single session of strenuous aerobic exercise. پرونده مقاله
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  4 - Galectin-3 concentrations in response to an exhaustive aerobic exercise
  Mohammad Ghassami Saeid Naraghi
  Introduction: Elevated levels of galectin-3 have been found to be significantly associated with higher risk of death in both acute decompensate heart failure and chronic heart failure populations. Although endurance exercise is a crucial element in cardiovascular diseas چکیده کامل

  Introduction: Elevated levels of galectin-3 have been found to be significantly associated with higher risk of death in both acute decompensate heart failure and chronic heart failure populations. Although endurance exercise is a crucial element in cardiovascular disease prevention, the relationship between exercise and plasma levels of galectin-3 is still unknown. The aim of this study was to determine the effect of an exhaustive aerobic exercise on galectin-3 levels in healthy males. Material & Methods: Fifteen healthy male (aged: 22.2 ± 2.3 years; ± SD) volunteered to participate in this study. The subjects were performed Bruce protocol as the exhaustive aerobic exercise. The blood sample was taken before and immediately after the completion of the exhaustive aerobic exercise. Wilcoxon test and Spearman correlation test were used to analyze the data. Results: The results demonstrated that galectin-3 had no significant changes in response to the exhaustive aerobic exercise (297.6 ± 180.5 vs. 294.9 ± 190.3 pg/ml). No significant correlation was observed between the post-exercise levels of galectin-3 with body mass (r = 0.1, P = 0.7), BMI (r = ‒ 0.1, P = 0.7), body fat percentage (r = 0.06, P = 0.8), WHR (r = 0.02, P = 0.9), or VO2max (r = 0.2, P = 0.4). Conclusions: In conclusion, the exhaustive aerobic exercise had not significant effects on galectin-3 concentrations in healthy individuals. پرونده مقاله
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  5 - The effect of an exhausting aerobic exercise session on plasma NT-proBNP and galectine-3 levels in male runners
  Saeed Ilbeigi Hossein Saeedi Mohammad Esmaeil Afzalpour Asghar Haghighi Maryam Heidarian Mostafa Haghighi Masoud Nadrian Jahromi
  Introduction: Brain natriuretic peptide (BNP) is an indicator released by the effect of increased intra-ventricular pressure and increased volume of ventricular myocarditis. Galectin-3 is a protein produced by the production of myocardial macrophages. The purpose of thi چکیده کامل

  Introduction: Brain natriuretic peptide (BNP) is an indicator released by the effect of increased intra-ventricular pressure and increased volume of ventricular myocarditis. Galectin-3 is a protein produced by the production of myocardial macrophages. The purpose of this study was to investigate the effect of an exhaustive aerobic exercise session on plasma NT-proBNP and galectine-3 levels in male runners. Material & Methods: A total of 12 semi-professional male runners were selected as the subject. The Bruce test protocol was used to achieve the exhaustion. The blood sample was taken before and immediately after the completion of the exhaustive endurance exercise. Results: The results indicated that galectin-3 was increased after the exhaustive endurance exercise (P<0.05); however for NT-pro BNP no significant change was observed. Conclusions: Generally, the acute effect of exhaustive aerobic exercise on cardiac muscle function and the secretion of NT-pro BNP and galectin-3 seem to be different. It seems that galectin-3 has a higher sensitivity. However, more research is needed in this regard. پرونده مقاله
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  6 - The relationships between galectin-3 levels with cardiac structure and function in resistance-trained athletes
  Ebrahim Radmehr
  Introduction: Galectin-3 is a new and promising biomarker for heart failure and myocardial fibrosis. Although clinical studies indicated that galectin-3 levels are strongly associated with changes of left ventricular structure and function in patients with chronic heart چکیده کامل

  Introduction: Galectin-3 is a new and promising biomarker for heart failure and myocardial fibrosis. Although clinical studies indicated that galectin-3 levels are strongly associated with changes of left ventricular structure and function in patients with chronic heart failure, but these relationships in athletes are not well known. The present study was conducted to examine the relationships between galectin-3 levels with cardiac structure and function in resistance-trained athletes. Material & Methods: Fifteen resistance-trained male athletes (aged: 23.0 ± 1.4 years and BMI: 24.1 ± 1.4 kg/m2; ± SD) volunteered to participate in this study. Galectin-3 concentrations were assessed by enzyme-linked immunosorbent assay (ELISA) kits and cardiac morphology and function were assessed by echocardiography. Pearson correlation test was used to analyze the relationship between the variables. Results: The results demonstrated that there were no significant relationships between galectin-3 concentrations with left ventricle ejection fraction (LVEF) (r= ‒ 0.12 , P = 0.6), aorta (r = 0.12 , P = 0.6) and pulmonary artery diameter (r = 0.25 , P = 0.3), posterior wall thickness of left ventricle at end diastole (PWTLV) (r = ‒ 0.27 , P = 0.3), interventricular septal (r = ‒ 0.15 , P = 0.9), left ventricle end-diastolic volume (LVEDV) (r = 0.009 , P = 0.9), and left ventricle end-systolic volume (LVESV) (r = 0.24 , P = 0.3). Conclusions: In conclusion, galectin-3 concentration is not a powerful predictor for cardiac structure and function in resistance-trained athletes. پرونده مقاله