نقش جنسیت در سطح فاکتور رشد اندوتلیال عروقی سرم و پاسخ آن به فعالیت ورزشی

محورهای موضوعی : علوم ورزش

مهدی یادگاری ¹ , علی اصغر رواسی ² , عباسعلی گائینی ³ , هاجر پاکمنش ⁴ , پریناز مصدق ⁵

1 - دکتری تخصصی، گروه فیزیولوژی ورزشی دانشکده تربیت بدنی و علوم ورزشی، دانشگاه مازندران، بابلسر، ایران
2 - استاد، دکترای تخصصی فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی ، دانشگاه تهران، تهران، ایران
3 - استاد، دکترای تخصصی فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی ، دانشگاه تهران، تهران، ایران
4 - کارشناس ارشد، گروه فیزیولوژی ورزشی دانشکده تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران
5 - کارشناس ارشد، گروه فیزیولوژی ورزشی دانشکده تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران

تاریخ دریافت : 1400/04/15 تاریخ پذیرش : 1400/04/15 تاریخ انتشار : 1399/11/01

کلید واژه: جنسیت, توان هوازی, آنژیوژنز, فعالیت هوازی, فاکتور رشدی,

چکیده مقاله :

تفاوت های جنسیتی زیادی در شاخص های ظرفیت عملکردی و پاسخ به استرس ورزشی وجود دارد. فاکتور رشد آندوتلیال عروقی (VEGF) واسطه مهم در فرایند آنژیوژنز و از عوامل توسعه توان هوازی به شمار می رود. هدف پژوهش حاضر بررسی نقش جنسیت در سطح VEGF سرم و پاسخ آن به فعالیت ورزشی بود. 11 مرد و 11 زن (میانگین سنی80/1±80/23 و64/1±63/22 سال) غیر ورزشکار انتخاب و به اجرای یک جلسه فعالیت هوازی پیشرونده پرداخت اند. نمونه های سرمی قبل، بلافاصله و 2 ساعت بعد از اجرا جمع آوری و سطوح VEGF سرمی با کیت الایزا اندازه گیری شد. بررسی داده ها با استفاده از آزمون های آماری تحلیل واریانس با اندازه گیری های تکراری و t مستقل انجام شد. یافته ها نشان داد سطح VEGF سرمی زنان در حالت استراحت به طور معناداری از مردان بیشتر بود (002/0P= )، در حالی که این اختلاف بلافاصله (052/0P=) و دو ساعت بعد از فعالیت ورزشی (077/0P=) مشاهده نشد. بر اساس یافته های پژوهش حاضر به نظر می رسد در حالت استراحتی، زنان نسبت به مردان دارای سطح بالاتری از فاکتور رشدی اندوتلیال عروقی هستند اما در پاسخ به استرس ورزشی این مردان هستند که افزایش بیشتری در VEGF سرمی تجربه می کنند.

چکیده انگلیسی:

Men and women have significant differences in performance indicators and their response to exercise stress. Vascular endothelial growth factor (VEGF) is an important mediator in the process of angiogenesis and is one of the factors promoting aerobic capacity. The purpose of the present study was to investigate the role of gender in serum VEGF levels and its response to exercise. For this purpose 11 non- athletes male and 11 non- athletes Female (23/8 , 22/63 years) Were selected  and performed a single bout of progressive aerobic exercise. Blood samples was collected before, immediately and 2 hours post exercise and serum VEGF levels were measured by ELISA kit. ANOVA test (Repeated Measures) and independent t test were used to data analysis. The results showed that the serum VEGF level of women at rest was significantly higher than men         (P = 0.002), while this difference was not observed immediately (P = 0.052) and two hours after exercise (P = 0.07).  According to the findings of the present study, it seems that at rest, women have a higher level of vascular endothelial growth factor than men but in response to exercise stress men experience greater increase in serum VEGF.

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