تأثیر 8 هفته تمرین هوازی بر سطوح مایونکتین سرمی و مقاومت به انسولین در زنان چاق و دارای اضافه وزن
محورهای موضوعی : علوم ورزش
عبدالرضا کاظمی
1
,
خاطره نادری پور
2
1 - دانشیار فیزیولوژی ورزشی، گروه تربیت بدنی، دانشکده ادبیات و علوم انسانی، دانشگاه ولی عصر (عج) رفسنجان، رفسنجان، ایران
2 - کارشناسی ارشد فیزیولوژی ورزشی، گروه تربیت بدنی، دانشکده ادبیات و علوم انسانی، دانشگاه آزاد اسلامی، کرمان، ایران
کلید واژه: زنان چاق, مقاومت به انسولین, مایونکتین,
چکیده مقاله :
چاقی با بیماریهای قلبی عروقی، سندروم متابولیک و دیابت و مقاومت به انسولین مرتبط است. مایونکتین، مایوکاینی است که بیشتر از عضله اسکلتی ترشح و با چاقی ارتباط معکوس دارد. هدف از پژوهش حاضر بررسی اثر 8 هفته تمرین هوازی بر سطوح مایونکتین و مقاومت به انسولین در زنان چاق و دارای اضافه وزن می‌باشد. 21 زن چاق به دو گروه تمرین (11) و کنترل (10) تقسیم بندی شدند. برنامه تمرین ورزشی شامل 8 هفته،تمرین هوازی شامل 30 دقیقه دویدن با 50 تا 70 درصد حداکثر ضربان قلب بود. در دو هفته اول با 50 درصد، دو هفته دوم با 60، دو هفته سوم با 65 و دو هفته آخر با 70 درصد ضربان بود.48 ساعت قبل از شروع و 48 ساعت بعد از آخرین جلسه تمرینی خون‌گیری انجام و سطوح مایونکتین سرمی، گلوکز و انسولین اندازه گیری شد. از آزمون تحلیل کوواریانس برای بررسی تفاوت بین گروهی استفاده شد. تجزیه و تحلیل دادهها با نرم افزار SPSS نسخه 21 انجام گرفت. سطوح مایونکتین در گروه تجربی نسبت به گروه کنترل افزایش نشان داد اما معنیدار نبود) 08/0P=)، همچنین سطوح مقاومت به انسولین در گروه تجربی نسبت به گروه کنترل کاهش معنیدار نشان داد (006/0 P=).نتایج پژوهش که تمرین استقامتی سبب افزایش مایونکتین سرمی و کاهش مقاومت انسولین گردید. از طرف دیگر با توجه به نقش مایونکتین در افزایش جذب اسیدهای چرب، تمرینات ورزشی میتوانند نقش قابل توجهی در کاهش بیماریهای مرتبط با چاقی و ایفا کنند، بر اساس پژوهش حاضر، این تأثیر تا حدودی به نقش مایونکتین مرتبط است.
AbstractObesity is associated with cardiovascular disease, metabolic syndrome and diabetes, and insulin resistance. Myonectin is a type of myokine that has a high rate of secretion in skeletal muscle and is inversely related to obesity. This study aimed to investigate the effect of 8 weeks of aerobic exercise on myonectin levels and insulin resistance in obese and overweight women. In the present study, 21 overweight and obese women participated as subjects, who were divided into two groups of exercise and control. The exercise program was performed for 8 weeks, which included three sessions of aerobic exercise per week, each session lasting 30 minutes with an intensity of 50 to 70% of the maximum heart rate. The maximum heart rate in exercise was 50% in the first two weeks, 60% in the second two weeks, 65% in the third two weeks, and 70% in the last two weeks. Blood sampling was drawn 48 hours before the start and 48 hours after the last training session and serum levels of mayonectin, glucose, and insulin were measured. Analysis of covariance was applied to examine the differences between groups by using IMB SPSS v.21 software. Serum levels of myonectin increased in the exercise group compared to the control group, but this amount was not significant (P=0.08). Furthermore, the level of insulin resistance in the exercise group compared to the control group was significantly reduced (P=0.006). Based on the results, aerobic training led to an increase in serum levels of myonectin and a decrease in insulin resistance in the subjects of this study. It can be concluded that due to the role of mayonectin in increasing the absorption of fatty acids, aerobic exercise can play a significant role in reducing obesity-related diseases and metabolic syndrome, which according to the current results, this effect is relatively associated with the role of mayonectin.
References
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- Blaschke, F., Takata, Y., Caglayan, E., Law, RE., Hsueh, WA. (2006). Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes. Arterioscler Thromb Vasc Biol. 26(1):28-40.
- Boghrabadi, V., Hejazi, SM., Soltani, M., Behnam, VH., Kharazian, S., Soltani, A. (2012). The Effect of Aerobic Exercise on Leptin, Fasting Blood Sugar, Blood Insulin Levels and Insulin Resistant Factor in Patients with Type II Diabetes Mellitus.
- Després, J-P., Lemieux, I., Bergeron, J., Pibarot, P., Mathieu, P., Larose, E., (2008). Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol. 28(6):1039-49.
- Fox, AK., Kaufman, AE., Horowitz, JF. (2004). Adding fat calories to meals after exercise does not alter glucose tolerance. J Appl Physiol. 97(1):11-6.
- Hadji, L., Berger, E., Soula, H., Vidal, H., Géloën, A. (2014). White Adipose Tissue Resilience to Insulin Deprivation and Replacement. PloS one. 9(8):e106214.
- Hotamisligil GS. (2005). Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes. 54(suppl 2):S73-S8.
- Kraniou GN, Cameron-Smith D, Hargreaves M.(2006). Acute exercise and GLUT4 expression in human skeletal muscle: influence of exercise intensity. J Appl Physiol. 101(3):934-7.
- Lambers S, Van Laethem C, Van Acker K, Calders P. (2008). Influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients. Clin Rehabil. 22(6):483-92.
- Maggio AB, Wacker J, Montecucco F, Galan K, Pelli G, Mach F, et al. (2012). Serum resistin and inflammatory and endothelial activation markers in obese adolescents. J Pediatr. 161(6):1022-7.
- Mann S, Beedie C, Balducci S, Zanuso S, Allgrove J, Bertiato F. (2014). Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence. Diabetes Metab Res Rev. 30(4):257-68.
- Peterson JM. Mart, R., Bond, CE. (2014). Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5. PeerJ. 2:e605.
- Pessin, JE., Saltiel, AR. (2000). Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest. 106(2):165.
- Raschke, S., Ecke,l J. (2013). Adipo-myokines: two sides of the same coin—mediators of inflammation and mediators of exercise. Mediators Inflamm. 2013.
- Sardar, MA., Shamsian, AA., Taghavi, M. (2006). THE intraction effect of Glibenclamide and aerobic aerobic training on C-Peptide , Insulin and Insuline resistance in type 2 diabetic patients . Iranian Journal of Diabetes and Lipid Disorders. 6(1):91-9.
- Snowling, NJ., Hopkins, WG. (2006). Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients a meta-analysis. Diabetes care. 29(11):2518-27.
- Seldin, MM., Peterson, JM., Byerly, MS., Wei, Z., Wong, GW. (2012). Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 287(15):11968-80.
- Seldin, MM., Lei, X., Tan, SY., Stanson, KP., Wei, Z., Wong, GW. (2013). Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem. 288(50):36073-82.
- Stanson, KP., Wei, Z., William, G., Seldin, MM., Lei, X., Tan, SY. (2013). Skeletal muscle-derived myonectin.
- Tolfrey, K., Jones, AM., Campbell, IG. (2000). The effect of aerobic exercise training on the lipid-lipoprotein profile of children and adolescents. Sports Med. 29(2):99-112.
- Zou, C., Shao, J. (2008). Role of adipocytokines in obesity-associated insulin resistance. J Nutr Biochem. 19(5):277-86.
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References
- Abedi, B., Azarbayjani, MA., Peeri, M., Rasaee, MJ. (2011). The effect of a single session of resistance training on serum adiponectin level and insulin resistance index in sedentary men. Arak University of Medical Sciences Journal. 14(5):53-620.
- Blaschke, F., Takata, Y., Caglayan, E., Law, RE., Hsueh, WA. (2006). Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes. Arterioscler Thromb Vasc Biol. 26(1):28-40.
- Boghrabadi, V., Hejazi, SM., Soltani, M., Behnam, VH., Kharazian, S., Soltani, A. (2012). The Effect of Aerobic Exercise on Leptin, Fasting Blood Sugar, Blood Insulin Levels and Insulin Resistant Factor in Patients with Type II Diabetes Mellitus.
- Després, J-P., Lemieux, I., Bergeron, J., Pibarot, P., Mathieu, P., Larose, E., (2008). Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol. 28(6):1039-49.
- Fox, AK., Kaufman, AE., Horowitz, JF. (2004). Adding fat calories to meals after exercise does not alter glucose tolerance. J Appl Physiol. 97(1):11-6.
- Hadji, L., Berger, E., Soula, H., Vidal, H., Géloën, A. (2014). White Adipose Tissue Resilience to Insulin Deprivation and Replacement. PloS one. 9(8): e106214.
- Hotamisligil GS. (2005). Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes. 54(suppl 2): S73-S8.
- Kraniou GN, Cameron-Smith D, Hargreaves M.(2006). Acute exercise and GLUT4 expression in human skeletal muscle: influence of exercise intensity. J Appl Physiol. 101(3):934-7.
- Lambers S, Van Laethem C, Van Acker K, Calders P. (2008). Influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients. Clin Rehabil. 22(6):483-92.
- Maggio AB, Wacker J, Montecucco F, Galan K, Pelli G, Mach F, et al. (2012). Serum resistin and inflammatory and endothelial activation markers in obese adolescents. J Pediatr. 161(6):1022-7.
- Mann S, Beedie C, Balducci S, Zanuso S, Allgrove J, Bertiato F. (2014). Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence. Diabetes Metab Res Rev. 30(4):257-68.
- Peterson JM. Mart, R., Bond, CE. (2014). Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5. PeerJ. 2:e605.
- Pessin, JE., Saltiel, AR. (2000). Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest. 106(2):165.
- Raschke, S., Ecke,l J. (2013). Adipo-myokines: two sides of the same coin—mediators of inflammation and mediators of exercise. Mediators Inflamm. 2013.
- Sardar, MA., Shamsian, AA., Taghavi, M. (2006). THE intraction effect of Glibenclamide and aerobic aerobic training on C-Peptide , Insulin and Insuline resistance in type 2 diabetic patients . Iranian Journal of Diabetes and Lipid Disorders. 6(1):91-9.
- Snowling, NJ., Hopkins, WG. (2006). Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients a meta-analysis. Diabetes care. 29(11):2518-27.
- Seldin, MM., Peterson, JM., Byerly, MS., Wei, Z., Wong, GW. (2012). Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 287(15):11968-80.
- Seldin, MM., Lei, X., Tan, SY., Stanson, KP., Wei, Z., Wong, GW. (2013). Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem. 288(50):36073-82.
- Stanson, KP., Wei, Z., William, G., Seldin, MM., Lei, X., Tan, SY. (2013). Skeletal muscle-derived myonectin.
- Tolfrey, K., Jones, AM., Campbell, IG. (2000). The effect of aerobic exercise training on the lipid-lipoprotein profile of children and adolescents. Sports Med. 29(2):99-112.
- Zou, C., Shao, J. (2008). Role of adipocytokines in obesity-associated insulin resistance. J Nutr Biochem. 19(5):277-86.