بررسی اثرات عصاره و پودر پوست انار بر الگوی لیپیدی سرم و ساختار بافتی کلیه به‌دنبال مسمومیت تجربی با کادمیوم در بلدرچین ژاپنی
محورهای موضوعی :
آسیب شناسی درمانگاهی دامپزشکی
رحمت اله فتاحیان
1
,
محمرضا علیجانی
2
,
رسول رحیمی جونقانی
3
,
شهاب بهادران
4
1 - دانشیار گروه علوم پایه، دانشکده دامپزشکی، دانشگاه شهرکرد، شهرکرد، ایران.
2 - دانشجوی رشته دامپزشکی، دانشکده دامپزشکی، دانشگاه شهرکرد، شهرکرد، ایران.
3 - دانشجوی رشته دامپزشکی، دانشکده دامپزشکی، دانشگاه شهرکرد، شهرکرد، ایران.
4 - استادیار گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهرکرد، شهرکرد، ایران.
تاریخ دریافت : 1398/02/11
تاریخ پذیرش : 1398/11/27
تاریخ انتشار : 1399/02/01
کلید واژه:
انار,
کادمیوم,
الگوی لیپیدی,
بلدرچین ژاپنی,
بافت کلیه,
چکیده مقاله :
کادمیوم عنصر کمیابی است که مواجه طولانی با آن منجر به مسمومیت در انسان و حیوانات می‌گردد. هدف از مطالعه حاضر، بررسی اثرات عصاره و پودر پوست انار بر الگوی لیپیدی سرم و ساختار بافتی کلیه به‌دنبال مسمومیت با کادمیوم در بلدرچین ژاپنی بود. بدین منظور تعداد 510 قطعه جوجه بلدرچین ژاپنی 7 روزه به 10 گروه مساوی تقسیم شدند. گروه‌های 1 و 2 به‌ترتیب به‌عنوان کنترل منفی و کنترل مسمومیت با کادمیوم با دز ppm 20، گروه‌های 3 و 4 به ترتیب به‌عنوان دریافت کننده عصاره 1/0 و 2/0 درصد پوست انار به‌همراه ppm 20 کادمیوم، گروه های 5 و 6 به ترتیب به‌عنوان دریافت کننده پودر 1 و 2 درصد پوست انار به‌همراه ppm 20 کادمیوم، گروه 7 به‌عنوان دریافت کننده عصاره 1/0 درصد پوست انار، گروه 8 به‌عنوان دریافت کننده عصاره 2/0 درصد پوست انار و گروه‌های 9 و 10 به ترتیب به‌عنوان دریافت کننده پودر 1 و 2 درصد پوست انار انتخاب شدند. در روز 42، همه پرندگان کشتار شده و از بافت کلیه آن ها مقاطع بافتی تهیه گردید و با استفاده از شبکه نقطه‌ای تحت بررسی استریولوژی قرار گرفت. نتایج حاکی از عدم وجود اختلاف آماری معنی‌دار بین گروه‌های مختلف از لحاظ شمارش تعداد لوله‌های پیچیده دور و مساحت بافت بینابینی کلیه بود. اما اختلاف آماری معنی‌داری از لحاظ شمارش تعداد لوله‌های پیچیده نزدیک در واحد سطح بین گروه‌های 9 و 2 مشاهده گردید (05/0p < ). همچنین یافته‌های پاتولوژی، آسیب‌های بافتی را در گروه‌های دریافت کننده کادمیوم نشان داد. همچنین مشخص گردید که میزان کلسترول در گروه دریافت کننده عصاره 2/0 درصد پوست انار به علاوه کادمیوم و گروه دریافت کننده عصاره 1/0 درصد کاهش معنی‌داری نسبت به گروه کنترل کادمیوم داشت (05/0p < ). مطالعه حاضر نشان داد که استفاده از عصاره و پودر پوست انار تا‌حدودی باعث کاهش آسیب کلیه و بهبود الگوی لیپیدی سرم در مسمومیت با کادمیوم در جوجه بلدرچین های ژاپنی می‌شود.
چکیده انگلیسی:
Chronic exposure to cadmium, a trace metal, leads to poisoning in humans and animals. The purpose of this study was to investigate the effects of pomegranate skin extract and powder on tissue structure of the kidneys following experimental cadmium poisoning in Japanese quail. For this purpose, 510 seven day old Japanese quail chicks were divided into 10 groups. Groups 1 and 2 served as negative control and cadmium poisoning control (20 ppm) respectively, groups 3 and 4 received 0.1% and 0.2% pomegranate skin extract along with 20 ppm of cadmium respectively, groups 5 and 6 received 1% and 2% pomegranate skin powder along with 20 ppm of cadmium respectively, groups 7 and 8 received 0.1% and 0.2% pomegranate skin extract respectively and groups 9 and 10 received 1% and 2% pomegranate skin powder respectively. On day 42, all birds were slaughtered and kidney samples were removed from the abdominal area and transferred to formalin, then 5 micrometer sections were prepared and stained and a stereological study was performed using a point grid. The results showed no significant difference between the groups in the number of distal tubules and the area of the interstitial tissue. However, significant differences were observed in the number of proximal tubules between groups 9 and 2. Pathologic findings also revealed tissue damages in treatment groups which had received cadmium. Cholesterol levels were significantly decreased in groups which had received 0.2% and 0.1% pomegranate skin extract along with cadmium in comparison to cadmium control group. It can be concluded that the use of pomegranate skin extract and powder does somewhat improve recovery conditions in the kidney structure after administration of cadmium.
منابع و مأخذ:
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Aviram, M., Dornfeld, L., Rosenblat, M., Volkova, N., Kaplan, M., Coleman, R., et al. (2000). Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E–deficient mice. The American Journal of Clinical Nutrition, 71(6): 1062-1076.
Babu, K.R., Rajmohan, H.R.R. and Rajan, B.K.M. (2006). Plasma lipid peroxidation and erythrocyte antioxidant enzymes status in workers exposed to cadmium. Toxicology and Industrial Health, 22(3): 329-335.
Bernard, A., Lauwerys, R., and Amor, A.O. (1992). Loss of glomerular polyanion correlated with albuminuria in experimental cadmium nephropathy. Archives of Toxicology, 66(2): 272-278.
Beytut, Y., Kamiloglu, B. and Aksakal, H .(2003). Role of dietary vitamin E in cadmium-induced oxidative damage in rabbit’s blood, liver and kidneys. International Journal for Vitamin and Nutrition Research, 73(2): 351-355.
Bhandari, P.R. (2012). Pomegranate (Punica granatum L). Ancient seeds for modern cure? Review of potential therapeutic applications. International Journal of Nutrition, Pharmacology, Neurological Diseases, 2(3): 171.
Boujelben, M., Ghorbel, F., Vincent, C., Makni-Ayadi, F., Guermazi, F., Croute, F., et al. (2006). Lipid peroxidation and HSP72/73 expression in rat following cadmium chloride administration: interactions of magnesium supplementation. Experimental and Toxicologic Pathology, 57(7): 437-443.
Chwełatiuk, E., Włostowski, T., Krasowska, A. and Bonda, E. (2006). The effect of orally administered melatonin on tissue accumulation and toxicity of cadmium in mice. Journal of Trace Elements in Medicine and Biology, 19(4): 259-265.
Commission, E. (2001). Commission Regulation (EC) No 466/2001 of 8 March 2001 setting maximum levels for certain contaminants in foodstuffs. Brussels: European Commission, 56(3): 12-13.
El-Sharaky, A., Newairy, A., Badreldeen, M., Eweda, S. and Sheweita, S. (2007). Protective role of selenium against renal toxicity induced by cadmium in rats. Toxicology, 235(19): 185-193.
Friedewald, W.T., Levy, R.I. and Fredrickson, D.S. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18(6): 499-502.
Fani makki, O., Ebrahimzadeh, A., Ansari, N.H. and Ghazaghi, M. (2013). Effect of Milk thistle (Silybum marianum L.) and Thyme (Thymus vulgaris L.) herbs on immunity and some blood metabolites in broiler chicks. Journal of Veterinary Clinical Pathology, 7(26): 1836-1843. [In Persian]
Garcá-Fernández, A., Sanchez-Garcia, J., Gomez-Zapata, M. and Luna, A. (1996). Distribution of cadmium in blood and tissues of wild birds. Archives of Environmental Contamination and Toxicology, 30(3): 252-258.
Goyer, R.A., Miller, C.R., Zhu, S. and Victery, W. (1989). Non-metallothionein-bound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat. Toxicology and Applied Pharmacology, 101(4): 232-244.
Heber, D., Schulman, R.N. and Seeram, N.P. (2006). Pomegranates: ancient roots to modern medicine. CRC Press, 30(7): 25-28.
Howard, C.V. and Reed, M.G. (1998). Unbiased stereology Three-dimensional measurement in microscopy. Oxford: Bios Scientific Publishers, 3(1): 143.
Ikeda, M., Ezaki, T., Moriguchi, J., Fukui, Y., Ukai, H., Okamoto, S. and Sakurai, H. (2005). The threshold cadmium level that causes a substantial increase in β2-microglobulin in urine of general populations. The Tohoku Journal of Experimental Medicine, 20(5): 247-261.
Järup, L. (2002). Cadmium overload and toxicity. Nephrology Dialysis Transplantation, 17(1): 35-39.
Jin, T., Leffler, P. and Nordberg, G.F. (1987). Cadmium-metallothionein nephrotoxicity in the rat: transient calcuria and proteinuria. Toxicology, 45(5): 307-317.
Jurczuk, M., Brzóska, M.M., Moniuszko-Jakoniuk, J., Gałażyn-Sidorczuk, M. and Kulikowska-Karpińska, E. (2004). Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol. Food and Chemical Toxicology, 42(7): 429-438.
Karimi, O., Hesaraki, S. and Mortazavi, S.P (2017). Histological and Functional Alteration in the Liver and Kidney and the Response of Antioxidants in Japanese quail Exposed to Dietary Cadmium. Iranian Journal of Toxicology, 11(3): 19-26.
Khateeb, J., Gantman, A., Kreitenberg, AJ., Aviram M. and Fuhrman, B. (2010). Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-γ pathway. Artherosclerosis, 208(3): 119-25.
Kim, Y.S., Hwang, J.W., Kang, S.H., Kim, E.H., Jeon, Y.J., Jeong., et al. (2014). Thymol from Thymus quinquecostatus Celak. protects against tert-butyl hydroperoxide-induced oxidative stress in Chang cells. Journal of Natural Medicines, 68(2): 154-162.
Kumar, K.P., Reddy, V.R. and Prakash, M.G. (2018). Effect of supplementing pomegranate (punicagranatum) peel extract on serum biochemical parameters and immune response in broiler duringsummer. Pharma Innovation, 7(1): 591-601.
Larregle, E.V., Varas, S.M. and Olivreos, L.B. (2008). Lipidmetabolism in liver of rat exposed to cadmium. Food and Chemical Toxicology, 46(2): 1786-1792.
Larrosa, M., González-Sarrías, A., Yáñez-Gascón, M.J., Selma, M.V., Azorín-Ortuño, M., Toti, S., et al. (2010). Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism. The Journal of Nutritional Biochemistry, 21(1): 717-725.
Lee, C., Chen, L. and Wang, C. (2010). Anti-inflammatory effects of Punica granatum Linne in LPS-induced primary human chondrocytes. Planta Medica, 76(6): 659.
Leffel, E.K., Wolf, C., Poklis, A. and White Jr, K.L. (2003). Drinking water exposure to cadmium, an environmental contaminant, results in the exacerbation of autoimmune disease in the murine model. Toxicology, 188(11): 233-250.
Leiva, K.P., Rubio, J., Peralta, F. and Gonzales, G.F. (2011). Effect of Punica granatum (pomegranate) on sperm production in male rats treated with lead acetate. Toxicology Mechanisms and Methods, 21(3): 495-502.
Mason, J., Chemat, F. and Vinatoru, M. (2011). The extraction of natural products using ultrasound or microwaves. Current Organic Chemistry, 15(2): 237-47.
Matés, J.M., Pérez-Gómez, C. and De Castro, I.N. (1999). Antioxidant enzymes and human diseases. Clinical Biochemistry, 32(8): 595-603.
McFarland, C., Bendell-Young, L., Guglielmo, C. and Williams, T. (2002). Kidney, liver and bone cadmium content in the Western Sandpiper in relation to migration. Journal of Environmental Monitoring, 4(1): 791-795.
Mehraein-Ghomi, F., Basu, H.S., Church, D.R., Hoffmann, F.M. and Wilding, G. (2010). Androgen receptor requires JunD as a coactivator to switch on an oxidative stress generation pathway in prostate cancer cells. Cancer Research, 25 (3): 18-25.
Murugavel, P., Pari, L. (2007). Diallyl tetrasulfide modulates the cadmium-induced impairment of membrane bound enzymes in rats. Journal of Basic Clinical Physiology and Pharmacology, 18(3): 37- 48.
Nai, G.A., Golghetto, J.J. and Estrella, M.P. (2015). pH Dependence of Cadmium-Contaminated Drinking Water on the Development of Cardiovascular Injury in Wistar Rats. Biological Trace Element Research, 165(3): 81-85.
Parseh, H., Hassanpour, S., Emam-djome, Z. and Lavasani, A.S. (2012). Antimicrobial properties of Pomegranate (Punica granatum L.) as a Tannin rich Fruit, The 1st International and the 4th National Congress on Recycling of Organic Waste in Agriculture, Isfahan, Iran.
Renugadevi, J. and Prabu, S.M. (2009). Naringenin protects against cadmium-induced oxidative renal dysfunction in rats. Toxicology, 256(3): 128-134.
Renugadevi, J. and Prabu, S.M. (2010). Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Experimental and Toxicologic Pathology, 62(4): 471-481.
Ricci, D., Giamperi, L., Bucchini, A. and Fraternale, D. (2006) Antioxidant activity of Punica grantum fruits. Fitoterapia, 77(3): 310-312.
Rouzmehr, F., Mohit A., Khoshsekeh, M. and Hassanzadeh, M. (2014). The Effect Of The Additive Containing Artichoke Extract (Apc) On Growth Performance, Blood Cholesterol Level, Carcass Characteristics And Immune System Of Broiler Chickens. Journal of Veterinary Clinical Pathology, 8(29): 357-366. [In Persian]
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Adema, C.M., Van der Knaap, W. and Sminia, T. (1991). Ediated Cytotoxicity: The Role of Reactive Oxygen Intermediates. Reviews in Aquatic Sciences, 4(1): 201-223.
Aviram, M., Dornfeld, L., Rosenblat, M., Volkova, N., Kaplan, M., Coleman, R., et al. (2000). Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E–deficient mice. The American Journal of Clinical Nutrition, 71(6): 1062-1076.
Babu, K.R., Rajmohan, H.R.R. and Rajan, B.K.M. (2006). Plasma lipid peroxidation and erythrocyte antioxidant enzymes status in workers exposed to cadmium. Toxicology and Industrial Health, 22(3): 329-335.
Bernard, A., Lauwerys, R., and Amor, A.O. (1992). Loss of glomerular polyanion correlated with albuminuria in experimental cadmium nephropathy. Archives of Toxicology, 66(2): 272-278.
Beytut, Y., Kamiloglu, B. and Aksakal, H .(2003). Role of dietary vitamin E in cadmium-induced oxidative damage in rabbit’s blood, liver and kidneys. International Journal for Vitamin and Nutrition Research, 73(2): 351-355.
Bhandari, P.R. (2012). Pomegranate (Punica granatum L). Ancient seeds for modern cure? Review of potential therapeutic applications. International Journal of Nutrition, Pharmacology, Neurological Diseases, 2(3): 171.
Boujelben, M., Ghorbel, F., Vincent, C., Makni-Ayadi, F., Guermazi, F., Croute, F., et al. (2006). Lipid peroxidation and HSP72/73 expression in rat following cadmium chloride administration: interactions of magnesium supplementation. Experimental and Toxicologic Pathology, 57(7): 437-443.
Chwełatiuk, E., Włostowski, T., Krasowska, A. and Bonda, E. (2006). The effect of orally administered melatonin on tissue accumulation and toxicity of cadmium in mice. Journal of Trace Elements in Medicine and Biology, 19(4): 259-265.
Commission, E. (2001). Commission Regulation (EC) No 466/2001 of 8 March 2001 setting maximum levels for certain contaminants in foodstuffs. Brussels: European Commission, 56(3): 12-13.
El-Sharaky, A., Newairy, A., Badreldeen, M., Eweda, S. and Sheweita, S. (2007). Protective role of selenium against renal toxicity induced by cadmium in rats. Toxicology, 235(19): 185-193.
Friedewald, W.T., Levy, R.I. and Fredrickson, D.S. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18(6): 499-502.
Fani makki, O., Ebrahimzadeh, A., Ansari, N.H. and Ghazaghi, M. (2013). Effect of Milk thistle (Silybum marianum L.) and Thyme (Thymus vulgaris L.) herbs on immunity and some blood metabolites in broiler chicks. Journal of Veterinary Clinical Pathology, 7(26): 1836-1843. [In Persian]
Garcá-Fernández, A., Sanchez-Garcia, J., Gomez-Zapata, M. and Luna, A. (1996). Distribution of cadmium in blood and tissues of wild birds. Archives of Environmental Contamination and Toxicology, 30(3): 252-258.
Goyer, R.A., Miller, C.R., Zhu, S. and Victery, W. (1989). Non-metallothionein-bound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat. Toxicology and Applied Pharmacology, 101(4): 232-244.
Heber, D., Schulman, R.N. and Seeram, N.P. (2006). Pomegranates: ancient roots to modern medicine. CRC Press, 30(7): 25-28.
Howard, C.V. and Reed, M.G. (1998). Unbiased stereology Three-dimensional measurement in microscopy. Oxford: Bios Scientific Publishers, 3(1): 143.
Ikeda, M., Ezaki, T., Moriguchi, J., Fukui, Y., Ukai, H., Okamoto, S. and Sakurai, H. (2005). The threshold cadmium level that causes a substantial increase in β2-microglobulin in urine of general populations. The Tohoku Journal of Experimental Medicine, 20(5): 247-261.
Järup, L. (2002). Cadmium overload and toxicity. Nephrology Dialysis Transplantation, 17(1): 35-39.
Jin, T., Leffler, P. and Nordberg, G.F. (1987). Cadmium-metallothionein nephrotoxicity in the rat: transient calcuria and proteinuria. Toxicology, 45(5): 307-317.
Jurczuk, M., Brzóska, M.M., Moniuszko-Jakoniuk, J., Gałażyn-Sidorczuk, M. and Kulikowska-Karpińska, E. (2004). Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol. Food and Chemical Toxicology, 42(7): 429-438.
Karimi, O., Hesaraki, S. and Mortazavi, S.P (2017). Histological and Functional Alteration in the Liver and Kidney and the Response of Antioxidants in Japanese quail Exposed to Dietary Cadmium. Iranian Journal of Toxicology, 11(3): 19-26.
Khateeb, J., Gantman, A., Kreitenberg, AJ., Aviram M. and Fuhrman, B. (2010). Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-γ pathway. Artherosclerosis, 208(3): 119-25.
Kim, Y.S., Hwang, J.W., Kang, S.H., Kim, E.H., Jeon, Y.J., Jeong., et al. (2014). Thymol from Thymus quinquecostatus Celak. protects against tert-butyl hydroperoxide-induced oxidative stress in Chang cells. Journal of Natural Medicines, 68(2): 154-162.
Kumar, K.P., Reddy, V.R. and Prakash, M.G. (2018). Effect of supplementing pomegranate (punicagranatum) peel extract on serum biochemical parameters and immune response in broiler duringsummer. Pharma Innovation, 7(1): 591-601.
Larregle, E.V., Varas, S.M. and Olivreos, L.B. (2008). Lipidmetabolism in liver of rat exposed to cadmium. Food and Chemical Toxicology, 46(2): 1786-1792.
Larrosa, M., González-Sarrías, A., Yáñez-Gascón, M.J., Selma, M.V., Azorín-Ortuño, M., Toti, S., et al. (2010). Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism. The Journal of Nutritional Biochemistry, 21(1): 717-725.
Lee, C., Chen, L. and Wang, C. (2010). Anti-inflammatory effects of Punica granatum Linne in LPS-induced primary human chondrocytes. Planta Medica, 76(6): 659.
Leffel, E.K., Wolf, C., Poklis, A. and White Jr, K.L. (2003). Drinking water exposure to cadmium, an environmental contaminant, results in the exacerbation of autoimmune disease in the murine model. Toxicology, 188(11): 233-250.
Leiva, K.P., Rubio, J., Peralta, F. and Gonzales, G.F. (2011). Effect of Punica granatum (pomegranate) on sperm production in male rats treated with lead acetate. Toxicology Mechanisms and Methods, 21(3): 495-502.
Mason, J., Chemat, F. and Vinatoru, M. (2011). The extraction of natural products using ultrasound or microwaves. Current Organic Chemistry, 15(2): 237-47.
Matés, J.M., Pérez-Gómez, C. and De Castro, I.N. (1999). Antioxidant enzymes and human diseases. Clinical Biochemistry, 32(8): 595-603.
McFarland, C., Bendell-Young, L., Guglielmo, C. and Williams, T. (2002). Kidney, liver and bone cadmium content in the Western Sandpiper in relation to migration. Journal of Environmental Monitoring, 4(1): 791-795.
Mehraein-Ghomi, F., Basu, H.S., Church, D.R., Hoffmann, F.M. and Wilding, G. (2010). Androgen receptor requires JunD as a coactivator to switch on an oxidative stress generation pathway in prostate cancer cells. Cancer Research, 25 (3): 18-25.
Murugavel, P., Pari, L. (2007). Diallyl tetrasulfide modulates the cadmium-induced impairment of membrane bound enzymes in rats. Journal of Basic Clinical Physiology and Pharmacology, 18(3): 37- 48.
Nai, G.A., Golghetto, J.J. and Estrella, M.P. (2015). pH Dependence of Cadmium-Contaminated Drinking Water on the Development of Cardiovascular Injury in Wistar Rats. Biological Trace Element Research, 165(3): 81-85.
Parseh, H., Hassanpour, S., Emam-djome, Z. and Lavasani, A.S. (2012). Antimicrobial properties of Pomegranate (Punica granatum L.) as a Tannin rich Fruit, The 1st International and the 4th National Congress on Recycling of Organic Waste in Agriculture, Isfahan, Iran.
Renugadevi, J. and Prabu, S.M. (2009). Naringenin protects against cadmium-induced oxidative renal dysfunction in rats. Toxicology, 256(3): 128-134.
Renugadevi, J. and Prabu, S.M. (2010). Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Experimental and Toxicologic Pathology, 62(4): 471-481.
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