مروری بر روش فتودینامیک تراپی با رویکرد حسگر های نوری مختلف
محورهای موضوعی :
زیست شناسی سلولی تکوینی گیاهی و جانوری ، تکوین و تمایز ، زیست شناسی میکروارگانیسم
پرنیا همتی
1
,
سید مهدی طبایی
2
,
مینا سادات نادری
3
1 - گروه زیست شناسی ، دانشکده علوم زیستی، دانشگاه آزاد اسلامی واحد تهران شمال، تهران
2 - گروه پژوهشی لیزر پزشکی، مرکز تحقیقات لیزر در پزشــکی، پژوهشــکده یارا، سازمان جهاد دانشگاهی علوم پزشکی تهران،
3 - گروه بیوفیزیک، دانشکده علوم زیستی، دانشگاه آزاد اسلامی واحد تهران شمال، تهران، ایران
تاریخ دریافت : 1401/09/27
تاریخ پذیرش : 1401/11/06
تاریخ انتشار : 1402/09/01
کلید واژه:
سرطان,
پوست,
فتودینایک تراپی,
حسگر های نوری,
لیزر کم توان,
چکیده مقاله :
فتودینامیک تراپی یک روش درمانی برای بیماری هایی مانند سرطان با حداقل تهاجم است. حساس کننده نور ، که به عنوان یک کاتالیزور در هنگام جذب نور عمل می کند، اکسیژن را به گونه های اکسیژن فعال سیتوتوکسیک تبدیل می کند که سلول های بدخیم را از طریق آپوپتوز ویا نکروز از بین می برد، عروق تومور را تخریب می کند و ایمنی را تحریک می کند. هدف از این مطالعه معرفی و بررسی عملکرد انواع حساسگر های نوری در درمان بیماری های مختلف از جمله بیماری های پوستی و سرطان پوست با روش فتودینامیک تراپی است . در این مطالعه ی مروری مقالات 10 سال اخیر در سایت هایgoogle scholar, PubMed, science direct, and Scopus, با عناوین حسگر های نوری ، فتودینامیک تراپی ، سرطان ، پوست و لیزر کم توان بررسی گردید. روش های درمانی مختلفی برای سرطان وجود دارد که روش درمانی فتودینامیکی یک روش درمانی امیدوار کننده برای انواع سرطان ها است . از مزایای این روش استفاده از تشعشعات غیر یونیزه کننده است که منجر به حداقل اسیب به DNA و بافت های اطراف می شود ، بنابراین این روش می تواند با توجه به بافت مورد نظر از حسگر های نوری مختلف با طول موج های نوری مختلف در بهبود روش های درمانی با مکانیسم منحصر به فرد خود اثر کمک کننده داشته باشد ..
چکیده انگلیسی:
Photodynamic therapy is a minimally invasive treatment for diseases such as cancer. The photosensitizer, which acts as a catalyst upon absorption of light, converts oxygen into cytotoxic reactive oxygen species that destroy malignant cells through apoptosis or necrosis, destroy tumor vasculature, and Stimulate immunity. An active photosensitizer activated by a specific biomarker is able to distinguish healthy from diseased cells, thereby reducing off-target photodamage. The purpose of this study is to introduce and evaluate the performance of different types of photosensitizers in the treatment of various diseases, including skin diseases and skin cancer with the photodynamic therapy method. In this review study, the articles of the last 10 years on the sites google scholar, PubMed, science direct, and Scopus, with the titles of photosensitizers, photodynamic therapy, cancer, skin, and low-power laser were reviewed. There are different treatment methods for cancer, and photodynamic therapy is a promising treatment method for all types of cancer. One of the advantages of this method is the use of non-ionizing radiation, which leads to minimal damage to DNA and surrounding tissues, so this method can improve the method by using different photosensitizers with different optical wavelengths according to the target tissue. treatments with their unique mechanism to have a helpful effect.
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