مروری بر اثرات درمانی سه گونه پسته وحشی (بنه، مصطکی و کلخونگ) در انسان
محورهای موضوعی : فصلنامه زیست شناسی جانوری
1 - گروه زیست شناسی، واحد دامغان، دانشگاه آزاد اسلامی، دامغان، ایران
کلید واژه: پسته وحشی, پسته کوهی, بنه, مصطکی, کلخونگ, سلامت,
چکیده مقاله :
پسته وحشی یکی از محصولات کشاورزی خودرو در ایران است که فواید بسیاری در صنایع دارویی، بهداشتی، پزشکی و خوراکی دارد. سه گونه پسته وحشی شامل بنه (Pistacia atlantica Desf.)، مصطکی (Pistacia lentiscus L.) و خینجوک یا کلخونگ (Pistacia khinjuk Stoks) در ایران وجود دارند که سرشار از مواد مغذی و پر انرژی بوده و خواص آنها در برخی موارد از پسته خوراکی آجیل بیشتر است. از درخت پسته وحشی یا بنه صمغی ترشح میشود که به سقز معروف است و دارای خواص درمانی بسیاری است و میوه، روغن و صمغ آن در حوزه طب سنتی از دیرباز مورد استفاده بوده است. این مطالعهی مروری با بررسی منابع معتبر داخلی و خارجی به بررسی اثرات درمانی سه گونه پسته وحشی موجود در ایران میپردازد. به این منظور با استفاده از پایگاه مرکز اطلاعات علمی جهاد دانشگاهی (SID)، Scopus، ScienceDirect و PubMed با تاکید بر جدیدترین و مرتبطترین منابع، تعداد 82 مقاله انتخاب و بررسی شدند. نتایج بیانگر اثرات آنتیاکسیدانی، ضدالتهابی، ضدمیکروبی، ضدانگلی و درمانی فراوانی پسته وحشی هستند که مهمترین آنها عبارتند از: بهبود اضطراب و افسردگی، کمک به درمان دیابت، سرطان، آسیبهای قلبی، کبدی، کلیوی، استئوآرتریت، بهبود پارامترهای خونی (قند و چریی)، بیوشیمیایی (آنزیمهای کبدی)، هورمونهای تیروئیدی، پاسخ ایمنی و ترمیم مو، ناخن و انواع زخمها میباشد. مصطکی یک صمغ طبیعی و از بهترین داروهای طبیعی برای تقویت دستگاه گوارش است. این صمغ به درمان زخم معده، سوءهاضمه، رفلاکس، تنظیم حرکات روده، رفع یبوست و پاکسازی کبد و کلیهها کمک میکند. میوه کلخونگ بهعنوان خوشبوکننده دهان، برای دنداندرد، زخم معده، کاهش کلسترول و پیشگیری از بیماریهای قلبی عروقی کاربرد دارد.
Wild pistachios are one of the major agricultural products in Iran that have many benefits in the pharmaceutical, health, medical and food industries. Three species of wild pistachios, including Pistacia atlantica Desf., Pistacia lentiscus L. and Pistacia khinjuk Stoks, are found in Iran, which are rich in nutrients and high in energy, and their properties are in some cases greater than those of edible pistachios. It is secreted from the wild pistachio tree or gum tree, which is known as turpentine and has many therapeutic properties, and its fruit, oil, and gum have been used in traditional medicine for a long time. This review study examines the therapeutic effects of three species wild pistachio found in Iran by examining reliable domestic and foreign sources. For this purpose, 82 articles were selected and reviewed using the Scientific Information Database (SID), Scopus, ScienceDirect and PubMed databases, with an emphasis on the most recent and relevant sources. The results indicate that wild pistachios have antioxidant, anti-inflammatory, antimicrobial, antiparasitic and therapeutic effects, the most important of which are: improving anxiety and depression, helping to treat diabetes, cancer, heart, liver, kidney damage, osteoarthritis, improving blood parameters (sugar and cholesterol), biochemical (liver enzymes), thyroid hormones, immune response and repairing hair, nails and all types of wounds. Pistacia lentiscus is a natural gum and one of the best natural medicines for strengthening the digestive system. This gum helps treat stomach ulcers, indigestion, reflux, regulate bowel movements, relieve constipation and cleanse the liver and kidneys. The fruit of the Pistacia khinjuk is used as a mouth freshener, for toothache, stomach ulcers, reducing cholesterol and preventing cardiovascular diseases.
1. Hajisharifi A. The secret and mystery of herbal medecin. 1th ed. Tehran: Hafez Novin Publication Center. 2012;236-237.
2. Bozorgi M, Memariani Z, Mobli M, Salehi Surmaghi MH, Shams-Ardekani MR, Rahimi R. Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): a review of their traditional uses, phytochemistry, and pharmacology. Sci World J. 2013;2013:219815.
3. Ben Ahmed Z, Yousfi M, Viaene J, Dejaegher B, Demeyer K, Heyden YV. Four Pistacia atlantica subspecies (atlantica, cabulica, kurdica and mutica): A review of their botany, ethnobotany, phytochemistry and pharmacology. J Ethnopharmacol. 2021;265:113329.
4. Oryan M, Hakimi Meybodi M H, Ebrahimzadeh Ardekani M, Kiani B. Efficacy of Pistacia atlantica extract in the treatment of acne. J Dermatol Cosmet. 2018;9(2):93-99.
5. Mahjoub F, Akhavan Rezayat K, Yousefi M, Mohebbi M, Salari R. Pistacia atlantica Desf. A review of its traditional uses, phytochemicals and pharmacology. J Med Life. 2018;11(3):180-186.
6. Sehaki C, Jullian N, Ayati F, Fernane F, Gontier E. A review of Pistacia lentiscus polyphenols: chemical diversity and pharmacological activities. Plants (Basel). 2023; 12(2):279.
7. Azadmard Damirchi S, Mahmodi R, Sowti Khiabani M, Shirmohammadi M. Chemical composition and antioxidant properties of hull and core of Pistacia khinjuk stocks. Iran Food Sci Technol Res J. 2015;11(4):408-419.
8. Bahrebar, M, Mirzaei, A, Meghgian E, and Bahebar, A. Antioxidant activity of hydroalcoholic extract of cotoneaster fruit in vitro and in vivo in rats. Armaghan Danesh, 2012;17(6):540-551.
9. Tavakoli J, Hadad Khodaparast MH, Esmaeilzadeh Kenari R, Aminlari M, Sharif A. Evaluating antioxidant activity of Kolkhung skin oil as a new edible source in Iran. Iran Food Sci Technol Res 2013; 9(1):61-67.
10. Eghbali-Feriz S, Taleghani A, Al-Najjar H, Emami SA, Rahimi H, Asili J, Hasanzadeh S, Tayarani-Najaran Z. Anti-melanogenesis and anti-tyrosinase properties of Pistacia atlantica subsp. mutica extracts on B16F10 murine melanoma cells. Res Pharm Sci. 2018;13(6):533-545.
11. Taleghani A, Eghbali S, Shokouhnam P, Emami S A, Farhadi F, et al. Anti-melanogenic Activities of Different Extracts from Pistacia atlantica subsp. Kurdica. Jundishapur J Nat Pharm Prod. 2021;16(2):e69844.
12. Papada E, Forbes A, Amerikanou C, Torović L, Kalogeropoulos N, Tzavara C, Triantafillidis JK, Kaliora AC. Antioxidative efficacy of a Pistacia Lentiscus supplement and its effect on the plasma amino acid profile in inflammatory bowel disease: A randomised, double-blind, placebo-controlled trial. Nutrients. 2018;10(11):1779.
13. Papada E, Amerikanou C, Torović L, Kalogeropoulos N, Tzavara C, Forbes A, Kaliora AC. Plasma free amino acid profile in quiescent Inflammatory Bowel Disease patients orally administered with Mastiha (Pistacia lentiscus); a randomised clinical trial. Phytomedicine. 2019; 56:40-47.
14. Papada E, Gioxari A, Amerikanou C, Forbes A, Tzavara C, Smyrnioudis I, Kaliora AC. Regulation of faecal biomarkers in inflammatory bowel disease patients treated with oral mastiha (Pistacia lentiscus) supplement: A double-blind and placebo-controlled randomised trial. Phytother Res. 2019;33(2):360-369.
15. Ostovan M. The anti inflammatory effect of Pistacia lentiscus in a rat model of colitis. J Inflamm Res. 2020;13:369-376.
16. Pachi VK, Mikropoulou EV, Gkiouvetidis P, Siafakas K, Argyropoulou A, Angelis A, Mitakou S, Halabalaki M. Traditional uses, phytochemistry and pharmacology of Chios mastic gum (Pistacia lentiscus var. Chia, Anacardiaceae): A review. J Ethnopharmacol. 2020;254: 112485.
17. Ahmadi Basir Z, Hasani R, Birjandian Z, Ahmmadzadeh S, Mirghazanfari SM. The effect of Pistacia lentiscus L. extract on Formalin induced pain in the male rat paw. J Nurse Phys War. 2021;9(30):6-12.
18. Mohammadzadeh M, Babaeifar F, Babaei F. Combination thrapy of hydroalcoholic extract of Pistacia atlantica kurdica and fluvoxamine on spatial memory of immobilization rat. J Gorgan Univ Med Sci 2017;19(3):24-31.
19. Babaeifar F, Mohammadzadeh M, Ilkhanipour M, Babaei F. Effects of hydroalcoholic extract of mountain pistachio and fluvoxamine on anxiety behavior of male rats under immobilization stress. J Qom Univ Med Sci. 2017;11(9):10-19.
20. Babaeifar F, Mohammadzadeh M, Babaei F. Comparison of the effects of hydro-alcoholic extract of Pistacia atlantica kurdika and fluvoxamine drug on depression in male rat under immobilization stress. J Guilan Univ Med Sci. 2017; 26(103):1-13.
21. Azadbakht R, Jafarian Dehkordi M, Khanamani Falahatipour S, Ghasemi Pirbaluti A, Khanamani Falahatipour S. Hematological evaluation of hydroalcoholic extract of Pistachia atlantica Desf. in male Wistar rats. Iran Med Arom Plant Res. 2018;34(6):936-948.
22. Jafarian Dehkordi M, Azadbakht R, Fathi Hafshejani R, Khanamani Falahatipour S, Khanamani Falahatipour S. Baneh fruits (Pistacia atlantica) improved some biochemical parameters in wistar male rats. Pistachio Health. 2021;4(2):4-12.
23. Omidi H, Omidi H, Naqdibadi H. The effect of wild pistachio powder on the activity of phosphatidate phosphohydrolase enzyme and blood lipid profile of rats. J Medic Plants. 2008;7(26):70-78.
24. Heidarian E. Effects of pistachio nut powder on rat liver phosphatidate phosphohydrolase and serum lipids and lipoproteins profile. J. Ilam Uni. Med. Sci. 2008; 16(1):47-55.
25. Ghanbari Niaki A, Fathi R., Shahandeh F, Yazdani M, Hajizadeh A. The effect of endurance training and Pistacia atlantica (bene) extraction on resting plasma visfatin and lipids levels in female rats. Daneshvar Medicine, 2011;19(3):53-62.
26. Izadi Motlagh MH, Moghtadaei Khorasgani E. The effect of hydroalcoholic extract of Corium on testicular tissue and testosterone hormone in male Wistar rats. Anim Physiol Dev. 2020;13(2):75-84.
27. McVey MJ, Cooke GM, Curran IH, Chan HM, Kubow S, Lok E, Mehta R, et al. Effects of dietary fats and proteins on rat testicular steroidogenic enzymes and serum testosterone levels. Food Chem Toxicol. 2008;46(1):259-69.
28. Abe M, Ito Y, Oyunzul L, Oki-Fujino T, Yamada S. Pharmacologically relevant receptor binding characteristics and 5alpha-reductase inhibitory activity of free fatty acids contained in saw palmetto extract. Biol Pharm Bull. 2009;32: 646-50.
29. Porhemmat F, Shariati M, Sepehrara L. Effect of Pistacia vera oil on pituitary gonad axis and histological testis changes in adult male rats. Armaghane Danesh (Yasuj Univ Med Sci). 2013;18(8):641-649.
30. Tansaz M, Bahman M, Khodadoost M, Athari SS, Ghafarzadeh S, Kashafroodi H, Choopani R. Effects of compound honey syrup (Ma-ol-asal) on polycystic ovary syndrome (PCOS) induced by estradiol valerate in female rats. Iran J Obstet Gynecol Infertil. 2021;23(12):13-24.
31. Saeb M, Nazifi Habibabadi S, Mousavi SM, Jalaei J. Studying the effect of oral consumption of wild pistachio oil (Pistacia atlantica) on the levels of leptin and thyroid hormones in the serum of female rats. Zahedan J Res Med Sci (Tabibe-Shargh), 2007;9(4):263-274.
32. Saeb M, Nazifi, Beizaee A, Gheisari H, Jalaee J. Effect of wild pistachio oil on serum leptin concentration and thyroid hormones in the male rat. Iran J Endocrinol Metab. 2008; 9(4):429-437.
33. Saeb M, Nazifi S, Sabet M, Nazem H, Gheisari HR, Saeb S et al. Effect of dietary wild pistachio oil on serum thyroid hormones, lipids and leptin concentration in experimental hyperthyroidism in male rat. J Gorgan Univ Med Sci. 2009;11(4):8-15.
34. Nazifi S, Saeb M, Pourgonabadi S, Saeb S, Ansari Lari M. The effect of dietary wild pistachio oil (Pistacia atlantica) on serum thyroid hormones and leptin concentration in experimental hyperthyroidism in the female rat. Iran South Med J. 2011;14(1):1-8.
35. Choghakhori R, Abbasnezhad A, Yazdi M, Ahmadvand H. Antidiabetic, hypolipidemic, and antioxidant activities of Pistacia atlantica: A systematic review and meta-analysis of preclinical studies. Phytother Res. 2023;37(9): 3698-3711.
36. Majd FS, Talebi SS, Ahmad Abadi AN, Poorolajal J, Dastan D. Efficacy of a standardized herbal product from Pistacia atlantica subsp. Kurdica in type 2 diabetic patients with hyperlipidemia: A triple-blind randomized clinical trial. Compl Ther Clin Pract. 2022;48:101613.
37. Canudas S, Hernández-Alonso P, Galié S, Muralidharan J, Morell-Azanza L, Zalba G, García-Gavilán J, Martí A, Salas-Salvadó J, Bulló M. Pistachio consumption modulates DNA oxidation and genes related to telomere maintenance: a crossover randomized clinical trial. Am J Clin Nutr. 2019;109(6):1738-1745.
38. Sauder KA, McCrea CE, Ulbrecht JS, Kris-Etherton PM, West SG. Effects of pistachios on the lipid/lipoprotein profile, glycemic control, inflammation, and endothelial function in type 2 diabetes: A randomized trial. Metabolism. 2015; 64(11):1521-1529.
39. Hasan-Zaiem A, Saghebjoo M, Foadodini M, Saed-Mocheshi S. The Effect of Aerobic Training and Pistacia Atlantica Extract on the Levels of Heat Shock Protein 70 and Protein Carbonyl in the Heart Tissue of Diabetic Rats. J Isfahan Med Sch 2015; 33(347):1337-1348.
40. Mahmudzadeh T, Saghebjoo M, Seghatol Eslami A, Hedayati M. Effect of aerobic training and Pistacia atlantica extract consumption on pancre B-cellsatic function in streptozotocin-induced diabetic rats. Iran J Diabet Metab 2014; 13(3):252-262.
41. Hosseini M, Shemshaki A, Saghebjoo M, Gharari Arefi R. Effect of aerobic training and Pistacia atlantica extract consumption on plasma levels of lipocalin-2 and insulin resistance index in streptozotocin-induced diabetic rats. Intern Med Today. 2016;22(1):27-33.
42. Hojati V. The combined effects of saffron (Crocus sativus L.) and exercise on body health: A review study. J Chem Health Risks. 2025; 15(2):255-273.
43. Hojati, V., Shafahi, M. The effects of the antidiabetic drug metformin on other diseases: A review study. Expe Anim Biol. 2024;13(1):81-96.
44. Hojati V. A review of the therapeutic effects of Salvia species in Iran. J Anim Biol. 2023;15(3):1-21.
45. Ghamaridaz S, Hojati V, Molzemi S, Roudi B. The effect of kombucha mushroom and garlic extracts on blood biochemical parameters of healthy and diabetic rats. Iran J Diabet Metabol. 2023;23(4):214-224.
46. Zarekar M, Saghebjoo M, Foadodini M, Hedayati M. Combined effect of aerobic training and Pistacia athlantica extract on GLUT-4 protein expression and muscle glycogen in diabetic rats. Iran J Endocrinol Metab. 2014; 16(4):245-253.
47. Saghebjoo M, Mahmoudzadeh T, Thaqe El-eslami A, Hedayati M. The effect of aerobic exercise and wild pistachio extract on pancreatic beta cell repair in streptozotocin-induced diabetic mice. 9th International Conference on Physical Education and Exercise. 2015.
48. Vazifeshenas Darmiyan K., Hosseini M, Rezaei R, Ezi S, Malekaneh M. Effect of aqueous extract of wild pistachio (Pistacia atlantica) leaves on diabetic nephropathy in rat. Armaghan-E-Danesh, 2016;21(5):420-434.
49. Memariani Z, Tatari M, Zahedi M, Hesari Z, Davarian A, Kolangi F. Evaluation of the effect of Pistacia atlantica oleoresin on blood sugar, pressure and lipids in patients with type 2 diabetes: A Single-Blind, Placebo-Controlled Trial. Endocrinol Diabetes Metab. 2024; 7(4):e504.
50. Gioxari A, Amerikanou C, Valsamidou E, Kleftaki SA, Tzavara C, Kalaitzopoulou A, Stergiou I, Smyrnioudis I, Kaliora AC. Chios mastiha essential oil exhibits antihypertensive, hypolipidemic and anti-obesity effects in metabolically unhealthy adults - a randomized controlled trial. Pharmacol Res. 2023; 194:106821.
51.
Floris S, Di Petrillo A, Pintus F, Delogu GL. Pistacia lentiscus: Phytochemistry and Antidiabetic Properties. Nutrients. 2024;16(11): 1638. 52. Kant R, Singh A, Raina R, Dhingra V, Bairwa M, Kanwar V. Real-world safety and effectiveness of Pistacia lentiscus (mastic gum) in patients with diabetic gastroparesis: 24-week interim analysis postintervention. Indian J Pharmacol. 2024;56(1):4-9.
53. Mahjoub F, Salari R, Yousefi M, Mohebbi M, Saki A, Rezayat KA. Effect of Pistacia atlantica kurdica gum on diabetic gastroparesis symptoms: a randomized, triple-blind placebo-controlled clinical trial. Electron Physician. 2018;10(7):6997-7007.
54. Norasteh H, Mohammadi S, Nikravesh M, Taraz Jamshidi S. Protective effect of Pistacia atlantica on busulfan-induced renal-liver injury in laboratory mice. J Babol Univ Med Sci. 2020; 22(1):17-23.
55. Hadinia A, Hosseini SM, Ghanbari Hassanabad A, Arianpour R, Seyidi F, Askarian S. The effect of Khanjak fruit extract on the humoral immune system of rats. Armaghan Danesh, 2010;15(4):387-395.
56. Kord Zanganeh S, Ghorbani MR, Tatar A, Barzegar H. Effect of different levels of wild pistachio (Pistacia atlantica) leaves extract on performance, ceca microbial population and immunity responses in broiler chickens. Iran J Anim Sci Res. 2018;10(3):367-379.
57. Alsharairi NA. An analysis of three Pistacia species' phenolic compounds and their potential anticancer and cytotoxic activities on cancer cells-a review. Curr Issues Mol Biol. 2025;47(6):393.
58. Keikhaei F, Naghsh N, Modaresi M. The comparison between hydroethanolic extraction of Pistacia atlantica and suzin effects on growth inhibition of K562 cell line in vitro condition. J Arak Uni Med Sci 2014;17(6):66-73.
59. Seyed Alipour B, Pourakbar E, Taravati A. Investigation of the cytotoxic effect of ethanolic extract of wild pistachio leaves (Pistacia Khinjuk) on two cancer cell lines Hela and MCF-7. J Rafsanjan Univ Med Scie. 2015;14(11):939-952.
60. Ostovan, M, Anbardar, MH, Khazraei, H, Fazljou, SMB, Khodabandeh, Z, Shamsdin, SA, Araj Khodaei, M, Torbati, MA. The short-term effects of Pistacia lentiscus oil and sesame oil on liver and kidney pathology of rats and human cancer cell lines. Galen Med J. 2020;9(1):2001.
61. Yarmohammadi Jalali R, Abbasi S. A review of some effective plants on adrenal cancer. Med History. 2022;14(47):1-15.
62. Alwadi MAM, Sidhu A, Khaled MB, Aboul-Enein BH. Mastic (Pistacia lentiscus) gum and oral health: a state-of-the-art review of the literature. J Nat Med. 2023;77(3):430-445.
63. Adibifard A, Bozorgi M, Kolangi F, Enayati A, Daneshfard B, Gorji N, Memariani Z. Effects of Pistacia genus on gastrointestinal tract disorders: A systematic and comprehensive review. Fitoterapia. 2024;176:106038.
64. Moudi Z, Edozahi M, Emami SA, Asili J, Pour MS. Effects of mastic oleoresin on wound healing and episiotomy pain: A mixed methods study. J Ethnopharmacol. 2018;214:225-231.
65. Ebrahimi S, Farahpour MR, Najjar MS. Studying the effectiveness of the combination of Aloe vera gel (Aloe vera L.) with hydroethanolic extract of the skin of the pistachio fruit (Pistacia atlantica Desf) on the healing process of incision-shear wounds in diabetic laboratory mice. Iran Med Arom Plant Res. 2018;34(5):794-804.
66. Shahouzehi B, Sepehri G, Sadeghiyan S, Masoumi Ardakani Y. Ameliorative effects of Pistacia atlantica resin oil on experimentally-induced skin burn in rat. Res J Pharmacogn. 2019;6(1):29-34.
67. Sistani Karampour N, Arzi A, Rezaei A, Ghasemi F, Pashmforosh M. Gastroprotective effects of Pistacia atlantica extract on ethanol-induced gastric ulcers in rats. Jundishapur J Nat Pharm Prod. 2019;14(1):e13635.
68. Elyasi Ghahfarrokhi A, Saeedi M, Khanavi M, Mojtabavi S, Kobarfard F, Faramarzi MA. Chemical composition and biological effects of Pistacia atlantica Desf. oleoresin essential oil. Res J Pharmacogn. 2022;9(3):25-33.
69. Aala F, Khodaveisi S, Baghdadi E, Rezaei S. The antifungal effect of Pistacia atlantica subsp. Kurdica on the growth of Aspergillus parasiticus. J Sch Public Health Inst Public Health Res. 2016;13(4):79-84.
70. Sadeghpour M, Noorbakhsh F. The effect of the frsh peel extract pistachio (Pistacia atlantica) on the growth of Staphylococcus aureus, Streptococcus pyogenes and Bacillus cereus isolated from clinical specimens in vitro. Studies Med Sci. 2015; 26(9):813-823.
71. Mazarei A, Fahmideh L. Comparative evaluation of total phenol and flavonoid content, antioxidant and antibacterial activity of methanolic extracts of Artemisia annua L., Thymus vulgaris L., Matricaria chamomilla L., Salvia officinalis L. and Pistacia atlantica var mutica. Ecophytochem J Med Plants. 2018;6(3):78-95.
72. Ansari Cheharsughi MS, Ahmadi-Dastgerdi A, Gholami-Ahangaran M. Antibacterial effect of Capparis spinosa and Pistacia atlantica extracts on growth of Escherichia coli in vitro and in vivo. J Vet Clin Pathol. 2020;14(2):115-126.
73. Dolatyabi M, Adhami G, Marouf Y. Investigation of the anti-leishmanial effects of oil extract of mountain pistachio (Pistacia atlantica) on Leishmania major promastigotes in vitro. Updates Vet Microbiol. 2021;4(2):92-99.
74. Milia E, Bullitta SM, Mastandrea G, Szotáková B, Schoubben A, Langhansová L, Quartu M, Bortone A, Eick S. Leaves and fruits preparations of Pistacia lentiscus L.: A review on the ethnopharmacological uses and iImplications in inflammation and infection. Antibiotics (Basel). 2021;10(4):425.
75. Kohnepoushi SS, Dastan D, Nili Ahmadabadi A. Effects of Pistacia atlantica subsp. kurdica on cadmium-induced oxidative damage in rat kidney. Avicenna J Pharm Res. 2020;1(1):10-14.
76. Borzooeian G, Tanideh N, Lotfi M, Mokhtari M, Nazem H, Sani M, Salman-nezhad M, Koohi-hosseinabadi O, Daneshi S. Evaluation the effect of Pistacia atlantica hydro alcoholic extract with bone marrow- derived stem cells on induced knee osteoarthritis in rat. Iran J Orthop Surg. 2020;14(1):30-41.
77. Khamevar A, Ebrahimzadeh MA, Moosazadeh M, Shayesteh Azar M, Saeedi M, Bakhtiary Far A, Yousefi SS. Effectiveness of Pistacia atlantica on older adult knee osteoarthritis, a randomized triple blind clinical trial. Phytother Res. 2021;35(9):5125-5132.
78. Azizi F, Gorji N, Jokar R, Rezghi M, Shirafkan H, Moeini R. The effects of Pistacia atlantica Desf. Fruit oil on primary knee osteoarthritis: A randomized controlled clinical trial. J Ethnopharmacol. 2025;342:119387.
79. Soulaidopoulos S, Tsiogka A, Chrysohoou C, Lazarou E, Aznaouridis K, Doundoulakis I, Tyrovola D, Tousoulis D, Tsioufis K, Vlachopoulos C, Lazaros G. overview of Chios mastic gum (Pistacia lentiscus) effects on human health. Nutrients. 2022;14(3):590.
80. Milia EP, Sardellitti L, Eick S. Antimicrobial efficiency of Pistacia lentiscus L. derivates against oral biofilm-associated diseases-A narrative review. Microorganisms. 2023;11(6):1378.
81. Hassani AR, Baladi M, Amiri M, Hamze F, Salavati-Niasari M, Sharifi M, Hanna R. Effectiveness of plant-mediated synthesis of hydroxyapatite nano-particles impregnated in pistachio oleogum resin on mineral contents of human teeth. An in-situ single-blind controlled study. J Mech Behav Biomed Mater. 2023;148:106155.
82. Starace M, Granger C, Carpanese MA, Alessandrini A, Bruni F, Piraccini BM. Review of the literature on the efficacy and safety of a new cosmetic topical treatment containing Pistacia lentiscus and hyaluronic acid for the treatment of nail plate damages. J Cosmet Dermatol. 2022;21(11):5514-5518.