تاثیر یک دوره تمرین هوازی-مقاومتی بر سطوح پلاسمایی نروگلین 1 و اینترلوکین 6 در بیماران بای‌پس عروق کرونری

محورهای موضوعی : فصلنامه زیست شناسی جانوری

امین زاهدی انارکی ¹ (گروه تربیت بدنی و علوم ورزشی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران)
رامبد خواجه ای ² (گروه تربیت بدنی و علوم ورزشی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران)
امیر رشیدلمیر ³ (گروه بیوشیمی و متابولیسم ورزشی، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران)
آمنه برجسته ⁴ (گروه تربیت بدنی و علوم ورزشی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران)

تاریخ دریافت : 1400/10/25 تاریخ پذیرش : 1400/12/16 تاریخ انتشار : 1401/09/01

کلید واژه: تمرینات هوازی, مقاومتی, نروگلین1, اینترلوکین6, بای‌پس عروق کرونری,

چکیده مقاله :

بیماری سرخرگ کرونری در حال حاضر یکی از علل ناتوانی و مرگ ومیر در سراسر جهان است. هدف از پژوهش حاضر اثر هشت هفته تمرینات هوازی- مقاومتی بر نروگلین1 و اینترلوکین6 در بیماران بای پس عروق گرونری بود. روش پژوهش حاضر نیمه تجربی و با طرح پیش آزمون- پس آزمون بود. جامعه آماری کلیه بیماران بای پس عروق کونری شهر مشهد بودند. در مطالعه حاضرنمونه پژوهشی شامل24 مرد میانسال با دامنه سنی 75/3 ± 73/56 (سال)، قد 03/0 ± 58/1 (متر)، وزن 54/5 ± 11/68 (کیلوگرم)، شاخص توده بدن 47/2 ± 18/27 (کیلوگرم/مترمربع) و سابقه ی بیماری 75/8 ± 20/25 (ماه) پس ازعمل بای پس عروق کرونر تشکیل شده بود. براساس معیارهای ورود به تحقیق، در دو گروه دوازده تایی تجربی و کنترل قرارگرفتند. داده ها با استفاده از آزمون تی مستقل و تی همبسته در سطح معنی داری 05/0≥p و نرم افزار SPSS نسخه 21 تحلیل شدند. نتایج پژوهش حاضر نشان داد که هشت هفته تمرینات هوازی-مقاومتی سبب افزایش نروگلین1 (001/0= p)، و کاهش غیرمعنادار اینترلوکین6 در گروه تمرین ترکیبی نسبت به گروه کنترل شد (061/0= p). همچنین بر اساس نتایج آماری آزمون تی همبسته، افزایش معنی دار نروگلین1(001/0=p )، و کاهش غیر معنی دار اینترلوکین6 در گروه تمرین ترکیبی در پس آزمون نسبت به پیش آزمون مشاهده شد. (889/0=p ) که این تغییرات در گروه کنترل معنی دار نبود (331/0=p ، 789/0=p ). داده های پژوهش حاضر نشان داد تمرینات هوازی- مقاومتی با افزایش فاکتورهای مورد بررسی می تواند به بهبود وضعیت بیماران بای پس عروق کرونری کمک کند.

چکیده انگلیسی:

Coronary artery disease is currently one of the leading causes of disability and death worldwide. The present study aims at investigating the effect of eight weeks aerobic-resistance training on neuroglin-1 and interleukin-6 in patients with coronary artery bypass grafting. The research method was quasi-experimental and pre-test-post-test. The statistical population was all patients with coronary artery bypass grafting in Mashhad. Height 1.58 ± 0.03 (m), weight 68.11 ± 5.54 (kg), body mass index 27.18 ± 2.47 (2 kg / m2) and disease history 8.75 ± 25/20 (month) was formed after coronary artery bypass surgery. According to the inclusion criteria, they were divided into experimental (12) and control (12) groups. Data was analyzed using independent t-test and paired t-test at the significance level of P≥0.05 and SPSS software version 21. The results of the present study showed that eight weeks aerobic-resistance training increases neuroglin1 (P = 0.001) and insignificantly decreases interleukin 6 in the combination training group compared with the control group (P = 0.061). Statistical results of t-correlated t-test showed a significant increase in neuroglin1 (P = 0.001) and a non-significant decrease in interleukin 6 in the post-test combination test group compared with the pretest (P = 0.889). These changes were not significant in the control group (P = 0.331, P = 0.789. The data of the present study showed that aerobic-resistance training can improve the condition of patients with coronary artery bypass graft by increasing the studied factors.

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