Cross-linked sulfonated polyacrylamide (Cross-PAA-SO3H) attached to nano-Fe3O4 as a superior catalyst for the synthesis of oxindoles
محورهای موضوعی : Journal of Nanoanalysis
Hossein Shahbazi-Alavi
1
(
Young Researchers and Elite Club, Kashan Branch, Islamic Azad University, Kashan, Iran, E-mail addresses: hossien_shahbazi@yahoo.com
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Iran
)
Javad Safaei-Ghomi
2
(
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Iran
)
کلید واژه: Isatin, Nanocatalyst, Polyacrylamide, Nano-Fe3O4, Oxindoles,
چکیده مقاله :
Cross-linked sulfonated polyacrylamide (Cross-PAA-SO3H) attached to nano-Fe3O4 as an efficientheterogeneous solid acid catalyst has been used for the preparation of spiro[pyrazoloquinoline-oxindoles]and spiro[chromenopyrazolo-oxindoles] through a four-component reactions of phenylhydrazineor hydrazine hydrate, isatins, ketoesters and naphthylamine or 2-naphthol under reflux conditions inethanol. The remarkable advantages of this methodology are easy work-up, short reaction times, highto excellent product yields, operational simplicity, low catalyst loading and reusability of the catalyst.
