Hollow Mesoporous Silica Nanoparticles (HMSNs) Synthesis and in vitro Evaluation of Cisplatin Delivery
محورهای موضوعی : Journal of Nanoanalysis
Zohreh Jomeh Farsangi
1
(School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Keshavarz Blvd., Tehran, Iran)
Seyed Mehdi Rezayat
2
(School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Keshavarz Blvd., Tehran, Iran)
Ali Beitollahi
3
(Center of Excellence for advanced Materials and processing, Iran University of Science and Technology, Narmak, Tehran, Iran)
Saeed Sarkar
4
(School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Keshavarz Blvd., Tehran, Iran)
Mahmoudreza Jaafari
5
(Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran)
Amir Amani
6
(School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Keshavarz Blvd., Tehran, Iran)
کلید واژه: Cisplatin, Drug delivery, Hollow mesoporous silica, Sustained release,
چکیده مقاله :
Cisplatin continues to be a first line chemotherapy agent alone or in combination with other cytotoxic agents orradiotherapy. Dose-limiting side effects, intrinsic and acquired resistance are the main reasons for inventing and developing new ways of delivering cisplatin. Biocompatible hollow porous materials offer high void volume, shell porosity, low density and controllable size which make them promising platforms for efficient drug delivery systems. In this study, hollow mesoporous silica nanoparticles (HMSNs) were successfully synthesized by a hard-templating method. Further, the synthesized HMSNs were studied by characterizing their morphology, nanostructure, specific surface area, particle size distribution and chemical composition using FESEM, HRTEM, N2-Sorption and FTIR techniques, respectively. The high specific surface area (1201 m2g-1) of the prepared HMSNs resulted in relatively high loading capacity of cisplatin (35 wt.%). Furthermore, release test performed at pH value of 7.4 showed a sustained release pattern. The cytotoxicity of the formulated drug was also examined in c26 colon carcinoma cell lines by MTT assay. The drug loaded HMSNs showed a lower toxicity than free drug due to the sustained drug release.
