Synthesis of Chitosan Nanoparticles Loaded with Antibiotics as Drug Carriers and the Study of Antibacterial Activity
محورهای موضوعی : Journal of NanoanalysisMilad Golmohamadi 1 , Hamid reza Ghorbani 2 , Maryam Otadi 3
1 - Department of Chemical Engineering, Central Tehran Branch Islamic Azad University, Tehran, Iran
2 - Department of Chemical Engineering, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
3 - Department of Chemical Engineering, Central Tehran Branch Islamic Azad University, Tehran, Iran
کلید واژه: Clarithromycin, antibacterial activity, Nano-Carriers, Chitosan Nanoparticles,
چکیده مقاله :
In recent years, there is a lot of interest in synthesis of nanostructures as carriers for drug delivery.These structures are considered as a highly effective drug delivery system due to controlling drugrelease, protecting the pharmaceutical molecule, and environmentally friendly. In this study, thesynthesis of chitosan nanoparticles was carried out by chemical method. The nanoparticles size wasmeasured by dynamic light scattering (DLS). Also, it was used from atomic absorption spectrometry(AAS), FTIR and transmission electron microscopy (TEM) to confirm the loading of antibiotic ontonanoparticles and to calculate the percentage of the drug loaded. In addition, it was used forclarithromycin as antibiotic. The antibacterial activity was studied by the disc-diffusion methodand the effect of different concentrations of the drug in nano-carriers were investigated and it wasdetermined the optimum antibacterial activity of drug nanocarrier was happened in concentration0.6 gr/10 ml.
1. L. Zhang, D. Pornpattananangkul, C. M. J. Hu and C. M. Huang, Curr. Med. Chem. 17, 585 (2010).
2. P. Calvo, C. Remunan-Lopez, J. L. Vila-Jata and M. J. Alonso, J. Appl. Polym. Sci. 63, 125 (1997).
3. L. Brunet, D. Y. Lyon, E. M. Hotze, P. J. Alvarez and M. R. Wiesner, Environ. Sci. Technol. 43, 4355 (2009).
4. K. I. Okada, S. Hirono, M. Kawai, M. Miyazawa, A.Shimizu, Y. Kitahata, M. Ueno, S. Hayami and H. Yamaue, Anticancer Res. 37, 853 (2017).
5. M. R. Jones, K. D. Osberg, R. J. Macfarlane, M. R. Langille and C. A. Mirkin, Chem. Rev. 111, 3736 (2011).
6. Q. Li, S. Mahendra, D. Y Lyon, L. Bru-net, M. V Liga, D. Li and P. J.J Alvarez, Water Res. 42, 4591 (2008).
7. S.A. Marathe, R. Kumar, P. Ajitkumar, V. Nagaraja and D. Chakravortty, J. Antimicrob. Chemother. 68, 139 (2013).
8. A. J. Huh and Y. J. Kwon, J. Control. Release 156, 128 (2011).
9. L. Han, C. Tang and C. Yin, Biomater. 60, 42 (2015).
10. X. Zhu, A.F. Radovic-Moreno, J. Wu, R. Langer and J. Shi, Nano Today 9, 478 (2014).
11. T. Sagir, M. Huysal, Z. Durmus, B.Z. Kurt, M. Senel and S. Isık, Biomed. Pharmacother. 77, 182 (2016).
