Design of Biosensor for Diagnosis of Bio-molecules Using Surface Enhanced Raman Spectroscopy
محورهای موضوعی : Biomedical Spectroscopy, Microscopy, Imaging, Endoscopy
Babak Hassanshahi
1
(
Department of Electrical and Electronic Engineering, Islamic Azad University, Tabriz Branch, Tabriz, Iran
)
Sayyedjavad Sayyedfattahi
2
(
Department of Electrical and Electronic Engineering, Islamic Azad University-Tabriz Branch, Tabriz, Iran
)
کلید واژه: FDTD, Nano-Particle, Nano Structure, Raman spectroscopy, Plasmonic,
چکیده مقاله :
In recent years, surface enhanced Raman Spectroscopy (SERS) method have been applied in the area of biotechnology, nanotechnology and diagnostic issues. For that, nanoparticles have been arranged near the flat film structure. By doing so, it is found that the local field enhancement can be greatly improved. In this paper, using two type of nanoparticles namely Ag, Au, we have obtained a double resonance system structure. The process is carried out by the application of nanoparticles, Ag and Au with Ag as a grating coupler. The space and interspace of 3 nm and 5-20 nm for the two particles Au and Ag are considered, respectively. A double resonance system structure has been proposed and simulated with the LUMERICAL FDTD. Our result show that for nanoparticle-film coupling, the highest enhancement factor of 〖(10〗^13) can be obtained for Ag nanosphere and Ag-grating coupler. Finally the simulation results show that application of multiple couplings associated with Ag grating filed and tooth like binding of Ag grating coupling can be used to significantly improve the near-field enhancement.
[1] M. Fleischmann, P.J. Hendra, and A. McQuillan, “Raman spectra of pyridine adsorbed at a silver electrode,” Chemical Physics Letters, vol. 26, pp.163-66, 1974.
[2] S. Cong, X. Liu, Y. Jiang, W. Zhang, and Z. Zhao " Surface Enhanced Raman Scattering Revealed by Interfacial Charge-Transfer Transitions," The Innovation, vol. 1, pp. 100051 (1-22), 2020
[3] M. M. Hernández, P. J. Rivero, J. Goicoechea and F. J. Arregui, “Trends in the Implementation of Advanced Plasmonic Materials in Optical Fiber Sensors (2010–2020),” Chemosensors, vol. 9, pp. 64 (1-38), 2021.
[4] M. Choi, T. Kang, S. H. Choi and K. M. Byun, “Dual modal Plasmonic substrates based on a convective self-assembly technique for enhancement in SERS and LSPR detection,” Optics Express, Vol. 29, pp. 6179-6187, 2021.
[5] C. Junfan, Z. Cong, Z. Jie, and Z. Yong, “Raman enhancement of large-area silver grating arrays based on self-assembled polystyrene microspheres,” Optical Materials Express. Vol. 11, pp, 1234-1248, 2021
[6] B. Huang, J. Wang, S. Huo, and W. Cai, “Facile fabrication of silver nanoparticles on silicon for surface‐enhanced infrared and Raman analysis,” Surface and Interface Analysis, vol. 40, pp. 81-84, 2008.
[7] B. Messinger, K. Von Raben, R. Chang, and P. Barber, “Local fields at the surface of noble-metal microspheres,” Physical Review B, vol. 24, pp. 649-657, 1981
[8] E. Le Ru, M. Meyer, E. Blackie, and P. Etchegoin, “Advanced aspects of electromagnetic SERS enhancement factors at a hot spot,” Journal of Raman Spectroscopy, vol. 39, pp.1127-1134, 2008.
[9] P. Camargo, M. Rycenga, and Y. Xia, “Isolating and probing the hot spot formed between two silver nanocubes,” Angewandte Chemie International Edition. Vol. 48, pp. 2180 (1-4), 2009
[10] K. Kneipp, H. Kneipp, and H. Bohr, “Single-molecule SERS spectroscopy,” Surface-Enhanced Raman Scattering: Springer, vol. 60, pp. 261-277, 2006
[11] E. Le Ru and P. Etchegoin, “Rigorous justification of the|E|4 enhancement factor in surface enhanced Raman spectroscopy,” chemical Physics letters, vol. 423, pp.63-66, 2006.
[12] Y. Hou, J. Xu, W. Li, and X. Wang, “Coupled sub wavelength gratings for surface-enhanced Raman spectroscopy,” Physical Chemistry Chemical Physics, vol. 13, pp. 10946-109451, 2011.
[13] J. Camden, J. Dieringer, Y. Wang, D. Masiello, L. Marks, G. Schatz, and R. P. Van Duyne, “Probing the structure of single-molecule surface-enhanced Raman scattering hot spots,” Journal of the American Chemical Society, vol. 130, pp. 12616 (1-7), 2008.
[14] K. Ma, J. M. Yuen, N. C. Shah, J. T. Walsh, J.r. M. R. Glucksberg and R. P. Van Duyne, “In Vivo, Transcutaneous Glucose Sensing Using Surface-Enhanced Spatially Offset Raman Spectroscopy: Multiple Rats, Improved Hypoglycemic Accuracy, Low Incident Power, and Continuous Monitoring for Greater than 17 Days” Anal. Chem. Vol. 83, pp. 9146–9152, 2011.
[15] E. Le Ru, E. Blackie, M. Meyer, P. Etchegoin, “Surface enhanced Raman scattering enhancement factors: a comprehensive study,” The Journal of Physical Chemistry C, vol. 111, pp. 13794-13803, 2007.
[16] J. Gersten and A. Nitzan, “Electromagnetic theory of enhanced Raman scattering by molecules adsorbed on rough surfaces,” The Journal of Chemical Physics, vol. 73, pp. 3023-3037, 1980.
[17] B. Sharma, R. Frontiera, A. Henry, E. Ringe, and R. Van Duyne, “SERS: materials, applications, and the future,” Materials today, vol. 15, pp.16-25, 2012.
[18] A. Haes, C. Haynes, A. McFarland, G. Schatz, R. Van Duyne, and S. Zou, “Plasmonic materials for surface-enhanced sensing and spectroscopy,” MRS bulletin, vol. 30, pp. 368-375, 2005.
[19] H. Wei, F. Hao, Y. Huang, W. Wang, P. Nordlander, and H. Xu, “Polarization dependence of surface-enhanced Raman scattering in gold nanoparticle− nanowire systems,” Nano letters, vol. 8, pp. 2497-502, 2008.
[20] H. Xu and M. Käll, “Polarization‐Dependent Surface‐Enhanced Raman Spectroscopy of Isolated Silver Nanoaggregates,” ChemPhysChem, vol. 4, pp. 1001-1005, 2003.
[21] Y. Zhou, X. Li, X. Ren, L. Yang, and J. Liu, “Designing and fabricating double resonance substrate with metallic nanoparticles–metallic grating coupling system for highly intensified surface-enhanced Raman spectroscopy,” Analyst, vol. 139, pp. 4799-4805, 2014.
[22] Z. Yang, J. Aizpurua, and H. Xu, “Electromagnetic field enhancement in TERS configurations,” Journal of Raman Spectroscopy, vol. 40, pp. 1343-1348, 2009.
[23] E. Hao and G. Schatz, “Electromagnetic fields around silver nanoparticles and dimers,” The Journal of chemical physics, vol. 120, pp. 357-66, 2004.
[24] J. Lee, J. Nam, K. Jeon, D. Lim, H. Kim, S. Kwon, H. Lee, and Y. D. Suh, “Tuning and maximizing the single-molecule surface-enhanced Raman scattering from DNA-tethered nanodumbbells,” ACS nano, vol. 6, pp. 9574-9584, 2012.
[25] Z. Yang, Q. Li, F. Ruan, Z. Li, B. Ren, H. Xu, and Zh. Tian “FDTD for Plasmonics: Applications in enhanced Raman spectroscopy,” Chinese Science Bulletin, vol. 55, pp. 2635-2642, 2010.
[26] P.B. Johnson and R. Christy, “Optical constants of the noble metals,” Physical review B, vol. 6, pp. 4370 (1-10), 1972.
[27] T. L. McMeekin, M. L. Groves, and N. J. Hipp, “Refractive Indices of Amino Acids, Proteins, and Related Substances,” Advances in Chemistry, Vol. 44, pp. 54-66, 1964.
[28] H. Zhao, P. H. Brown, and P. Schuck, “On the Distribution of Protein Refractive Index Increments,” Biophysical Journal, Vol. 100, pp. 2309–2317, 2011.
[29] H. P. Erickson, “Size and Shape of Protein Molecules at the Nanometer Level Determined by Sedimentation, Gel Filtration, and Electron Microscopy,” Biological Procedures Online, Vol. 11, pp. 32-51, 2009.
[30] X. Qian and S. Nie, “Single-molecule and single-nanoparticle SERS: from fundamental mechanisms to biomedical applications,” Chemical Society Reviews, vol. 37, pp. 912-920, 2008.
