Solvent-free One Pot Biginelli Method for Synthesis of new Dihydropyrimidinone compounds
محورهای موضوعی : Journal of Chemical Reactivity and Synthesis
1 - Department of polymer engeeniering, Tehra Science and Reaserch Branch, Islamic Azad University,Tehran, Iran
کلید واژه: Solvent-free, One-pot, Biginelli reaction, Dihydropyrimidinones,
چکیده مقاله :
An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.
