SOLVENT-FREE SYNTHESIS OF PYRROL DERIVATIVES USING MULTICOMPONENT REACTIONS OF 1,3-DICARBONYLS, ACTIVATED CARBONYL COMPOUNDS, AND PRIMARY ALKYLAMINES
محورهای موضوعی : Journal of Chemical Reactivity and SynthesisFaramarz Rostami-Charati 1 , Mehdi Shahraki 2 , Mohammad R. Hosseini- Tabatabaei 3 , Zinatossadat Hossaini 4
1 - Islamic Azad University, Zahedan Branch, Zahedan, Iran
2 - Islamic Azad University, Zahedan Branch, Zahedan, Iran
3 - Islamic Azad University, Zahedan Branch, Zahedan, Iran
4 - Chemistry Department, Islamic Azad University, Qaemshahr Branch,
Mazandaran, Iran
کلید واژه: Solvent-free, One-pot reactions, 1, 3-Dicarbonyl, Pyrroles, Primary Amines,
چکیده مقاله :
A one-pot synthesis of pyrrole derivatives via reaction between activated carbonyl compounds, primary amines and 1,3-dicarbonyls under solvent-free conditions is described.
1. J. Zhu, H. Bienayme, Wiley.,VCH Verlag. Weinheim, 2005.
2. M. Torok, M. Abid, S. C. Mhadgut, B. Torok, Biochemistry 2006, 45, 5377.
3. R. J. Sundberg, In Comprehensive Heterocyclic Chemistry; A. Katritzky, C. W. Rees, E. F. V. Scriven, Eds; Pergamon: Oxford, 1996, 2, 119.
4. H.Tao, I. Hwang, D. L. Boger, Bioorg. Med. Chem. Lett. 2004, 14, 5979.
5. M. Baumgarten, N. Tyutyulkov, Chem. Eur. J. 1998, 4, 987.
6. J. Lehuede, B. Fauconneau, L. Barrier, M. Ourakow, A. Piriou, J. M. Vierfond, Eur. J. Med. Chem. 1999, 34, 991.
7. R. W. Burli, P. Jones, D. McMinn, Q. Le, J. X. Duan, J. A. Kaizerman, S. Difuntorum, H. E. Moser, Bioorg. Med. Chem. Lett. 2004, 14, 1259.
8. R. Jonas, M. Klockow, I. Lues, H. Pruecher, H. J. Schliep, H. Wurziger, Eur. J. Med. Chem. 1993, 28, 129.
9. W. A. Denny, G.W. Rewcastle, B. C. Baguley, J. Med. Chem. 1990, 33, 814.
10. V. J. Demopoulos, E. Rekka, J. Pharm. Sci. 1995, 84, 79.
11. M. Del Poeta, W. A. Schell, C. C. Dykstra, S. Jones, R. R. Tidwell, A. Czarny, M. Bajic, A. Kumar, D. Boykin, J. R. Perfect, Antimicrob. Agents Chemother. 1998, 42, 2495.
12. D. L. Boger, C. W. Boyce, M. A. Labrili, C. A. Sehon, Q. Lin, J. Am. Chem. Soc. 1999, 121, 54.
13. I.Yavari, M. Sabbaghan, Z. Hossaini, M. Ghazanfarpour-Darjani, Helv Chim Acta, 2008, 91, 1144.
14. S. Y. Wang, S. J. Ji, Tetrahedron 2006, 62, 1527.