reaction of thiohydantoins and ethylbromopyruvate for Synthesis of imidazo[2,1-b]thiazole 3-carboxylate

محورهای موضوعی : Journal of Chemical Reactivity and Synthesis

Nasimeh Zarei ¹ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran,)
Mohammad Mehdi Ghanbari ² (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)
Marzieh Jamali ³ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)
Mahboobeh Kiamarsi ⁴ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)
Pegah Mohagheghzadeh ⁵ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)

تاریخ دریافت : 1393/08/28 تاریخ پذیرش : 1394/02/12 تاریخ انتشار : 1394/01/12

کلید واژه: Thiohydantoin, Imidazo[2, 1-b]thiazole, Ethylbromopyruvate, anticancer, Thioxoimidazolidin,

چکیده مقاله :

Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate. These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions

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