One-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar
محورهای موضوعی : Journal of Chemical Reactivity and SynthesisAlireza Kiasat 1 , Maryam Nikmanesh 2
1 - Department of Chemistry , Shahid Chamran University , Ahwaz , Iran
2 - Department of Chemistry , Shahid Chamran University , Ahwaz , Iran
کلید واژه: Green Chemistry, Synthesis, solvent free, Phenytoin, Grinding,
چکیده مقاله :
phenytoine derivatives were synthesized , via the pinacol condensation with the reaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thiourea in presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle at room temperatures. The reaction was completed at short reaction times (approximately 15min) and pure products were obtained with high yields (81-94%).
