Microwave assisted synthesis of [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazine Derivatives
محورهای موضوعی : Journal of Chemical Reactivity and Synthesis
Javad Azizian
1
(Factually of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran.)
Ramin Miri
2
(Medicinal & Natural Products Chemistry Research Center , Shiraz University of Medical Sciences , Shiraz , Iran)
Mohammad Kazem Mohammadi
3
(Factually of science , Ahvaz Branch Islamic Azad University , Ahvaz , Iran .)
کلید واژه: heterocyclization, 5-Bromo-2, 4-dichloro-6-methylpyrimidine, Pyrimido[4, 5-e][1, 3, 4]thiadiazine, Binucleophile, Bielectrophile,
چکیده مقاله :
New pyrimido [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazines were synthesized via the cyclocondensation of alkyl-2-phenylhydrazinecarbodithioates as a binucleophile with 5-bromo-2,4-dichloro-6-methylpyrimidine as a bielectrophile , and replacement of C-7 chloro atom by hydrazine in ethanol as the solvent . This method has advantages over methods currently described in the literature for the construction of such heterocyclic ring systems.
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