Bronsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Multi-Component Solvent-Free Synthesis of Dihydropyrimidinones
محورهای موضوعی : Journal of Chemical Reactivity and SynthesisHeshmatollah Alinezhad 1 , Neda Ghobadi 2
1 - Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
2 - Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
کلید واژه: thiourea, Ionic liquid, reusable catalyst, Dihydropyrimidinone, Brønsted acidic,
چکیده مقاله :
An efficient and convenient procedure for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones by condensation of 1,3-dicarbonyl compounds, Aromatic and aliphatic aldehydes, and urea or thiourea in the presence of catalytic amount of Brønsted acidic ionic liquid 3-methyl-1-sulfonic acid imidazolium chloride {[Msim]Cl} under thermal solvent-free conditions reacted easily to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones and thiones. Straightforward and clean workup, short reaction time, good to excellent yields and reusability of the catalyst are the advantages of this method
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