Synthesis of imidazo[2,1-b]thiazole-3-carboxylate through the reaction of thiohydantoins and ethylbromopyruvate

محورهای موضوعی : Journal of Chemical Reactivity and Synthesis

Nasimeh Zarei ¹ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)
Mohammad Mehdi Ghanbari ² (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)
Marzieh Jamali ³ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)
Mahboobeh Kiamarsi ⁴ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)
Pegah Mohagheghzadeh ⁵ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)

تاریخ دریافت : 1395/03/09 تاریخ پذیرش : 1395/03/09 تاریخ انتشار : 1390/02/11

کلید واژه: Thiohydantoin, Imidazo[2, 1-b]thiazole, Ethylbromopyruvate, anticancer, Thioxoimidazolidin,

چکیده مقاله :

Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate. These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions