Synthesis of alkyl 2-(4-oxoquinazolin-3(4H)-yl) acrylate by nucleophilic additionof alkyl propiolates catalysed by Ph3P
محورهای موضوعی : Journal of Chemical Reactivity and Synthesis
Mehdi babakeshizadeh
1
(Department of Organic Chemistry, Karaj Branch, Islamic Azad university, Karaj, Iran)
Bita Mohtat
2
(Department of Organic Chemistry, Karaj Branch, Islamic Azad university, Karaj, Iran)
کلید واژه: Alkyl propiolates, Triphenylphosphine, 4-Hydroxyquinazoline, alkylacrylat,
چکیده مقاله :
4-Hydroxyquinazoline undergoes neutral conditions with alkyl propiolates in the presence of triphenylphosphine (0.26g), and by α substituation the corresponding 2-(4-oxoquinazolin-3(4H)-yl acrylate was obtained in good yields.
