Eight weeks of high intensity interval training improve the expression of interleukin-17 and interleukin-18 genes in the heart tissue of cadmium-poisoned rats
محورهای موضوعی : Journal of Physical Activity and HormonesAhmad Ahmadloo 1 , Sirous Farsi 2 , Mohammad Ali Azarbayjani 3
1 - Ph.D candidate in Exercise Physiology, Department of Physical Education, Larestan branch, Islamic Azad University, Larestan, Iran
2 - Assistant Professor in Exercise Physiology, Department of Physical Education, Larestan branch, Islamic Azad University, Larestan, Iran
3 - Professor in Exercise Physiology, Department of Physical Education, Central Tehran branch, Islamic Azad University, Tehran, Iran
کلید واژه: Cadmium, HIIT training, IL-17, IL-18,
چکیده مقاله :
Introduction: lL-17 and IL-18 are pro-inflammatory cytokines. The aim of present study is to evaluate the effect of endurance training on IL-17 and IL-18 in heart tissue of rats which have been poisoned by cadmium. Material & Methods: Twenty Wistar rats were randomly divided into four groups: 1) control, 2) sham, 3) cadmium and 4) high intensity interval training (HIIT training) with cadmium. HIIT training was performed 8 weeks and 3 days a week (80 to 110% of their VO2max). Cadmium groups received 2mg/kg cadmium intraperitoneally everyday. At the end of protocol, the rats were sacrificed and their heart tissues were prepared to measure gene expression of IL-17 and IL-18. The data was analyzed by independent sample t-test and one-way ANOVA (P≥ 0.05). Results: The HIIT training led to significantly reducing IL-17 and IL-18 gene expression in heart issue of rats (P= 0.001). Conclusion: The 8 weeks of HIIT training will improve the levels of pro-inflammatory cytokines in rats which have been poisoned by cadmium.
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