Effect of a strenuous aerobic exercise on sdLDL concentration in healthy men
محورهای موضوعی : Journal of Physical Activity and Hormones
1 - MS in Exercise Physiology, Department of Exercise physiology, Marvdasht branch, Islamic Azad University, Marvdasht, Iran
کلید واژه: sdLDL, Coronary heart disease, Intensive exercise, Lipoprotein subfractions,
چکیده مقاله :
Introduction: Clinical studies indicated that small dense LDL (sdLDL) levels are more powerful than LDL levels for the determination of severe stable coronary heart disease (CHD). The effects of intensive aerobic exercise on sdLDL levels are not well known; thus the aim of present study was to investigate effect of a strenuous aerobic exercise on sdLDL concentration in healthy men. Material & Methods: Elevenhealthy young men (aged: 20.8 ± 1.8 years; ± SD) volunteered to participate in this study. All the subjects were performed Repeated High-Intensity Endurance Test (RHIET) as a strenuous aerobic exercise. Blood samples were taken at baseline and immediately after the RHIET. Wilcoxon and paired-sample t-test was used to analyze the data. Results: The results showed that sdLDL (38.8 ± 11.3 mg/dl vs. 39.9 ± 11.3 mg/dl), TC (188.6 ± 36.2 mg/dl vs. 194.1 ± 42.2 mg/dl), TG (139.6 mg/dl ± 55.0 vs. 157.7 ± 79.7 mg/dl), LDL (109.1 ± 33.4 mg/dl vs. 121.5 ± 53.0 mg/dl) and HDL (44.0 ± 13.6 mg/dl vs. 44.6 ± 14.0 mg/dl) remained unchanged in response to strenuous aerobic exercise. Significant correlation was observed between changes of sdLDL with TC (r = 0.74, P = 0.008), TG (r = 0.65, P = 0.02) and LDL (r = 0.64, P = 0.03) levels. Conclusions: The results suggest strenuous aerobic exercise had not significant effect on blood lipids and lipoprotein subfractions.
1. Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, et al. National Heart, Lung, and Blood Institute; American College of Cardiology Foundation; American Heart Association: Implications of recent clinical trials for the National Cholesterol Education Program Adult Treat ment Panel III guidelines. Circulation 2004; 110: 227-239.
2. Ballantyne C, Arroll B, Shepherd J. Lipids and CVD management: towards a global consensus. Eur Heart J 2005; 26: 2224-2231.
3. Saito Y. The Japan Atherosclerosis Society Guidelines for Diagnosis and Treatment of Atherosclerotic Cardiovascular Disease 2002 (Editorial). J Atheroscler Thromb 2004; 11: 101-103.
4. Sniderman AD. How, when, and why to use apolipoprotein B in clinical practice. Am J Cardiol 2002; 90: 48i-54i.
5. Griffin BA. Lipoprotein atherogenicity: an overview of current mechanisms. Proc Nutr Soc 1999; 58: 163-169.
6. Berneis KK, Krauss RM. Metabolic origins and clinical significance of LDL heterogeneity. J Lipid Res 2002; 43: 1363-1379.
7. St-Pierre AC, Cantin B, Dagenais GR, Mauriège P, Bernard PM, Després JP, et al. Low-density lipoprotein subfractions and the long-term risk of ischemic heart disease in men, 13-year follow-up data from the Québec Cardiovascular Study. Arterioscler Thromb Vasc Biol 2005; 25: 553-559.
8. Koba S1, Yokota Y, Hirano T, Ito Y, Ban Y, Tsunoda F, et al. Small LDL-cholesterol is superior to LDL-cholesterol for determining severe coronary atherosclerosis. J Atheroscler Thromb 2008; 15: 250-260.
9. Myers J. Cardiology patient pages. Exercise and cardiovascular health. Circulation 2003; 107: e2-e5.
10. Ghasemianpoor J, Nematollahzadeh Mahani M. Effects of short term lifestyle activity modification on lipid profiles in obese and overweight middle aged men with type 2 diabetes.
J Physic Act Horm 2017; 1: 1-10.
11. Eskandary S, Rahimi E. Effects of eight weeks aerobic training, resistance training and concurrent training on the metabolic syndrome and HbA1c in men with type 2 diabetes. J Physic Act Horm 2017; 1: 51-64.
12. Nayeri khoob HR, Moghadasi M. Effect of 8 weeks regular resistance training on attenuation of sdLDL changes after single session of heavy resistance exercise. J Physic Act Horm 2017; 1: 39-50.
13. Medlow P, McEneny J, Murphy MH, Trinick T, Duly E, Davison GW. Lipoprotein subfraction oxidation in acute exercise and ageing. Free Radical Res 2016; 50: 345-353.
14. Yu HH, Ginsburg GS, O'Toole ML, Otvos JD, Douglas PS, Rifai N. Acute changes in serum lipids and lipoprotein subclasses in triathletes as assessed by proton nuclear magnetic resonance spectroscopy. Arterioscler Thromb Vasc Biol 1999; 19: 1945-1949.
15. Srisawasdi P, Chaloeysup S, Teerajetgul Y, Pocathikorn A, Sukasem C, Vanavanan S, et al. Estimation of plasma small dense LDL cholesterol from classic lipid measures. Am J Clin Pathol 2011; 136: 20-29.
16. Skoglund-Andersson C, Tang R, Bond MG, de Faire U, Hamsten A, Karpe F. LDL particle size distribution is associated with carotid intima-media thickness in healthy 50-year-old men. Arterioscleros Thrombos Vas Biol 1999; 19: 2422-2430.
17. Tsimikas S, Willerson JT, Ridker PM. C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J Am Coll Cardiol 2006; 47: C19-C31.
18. Zambon A, Hokanson JE, Brown BG, Brunzell JD. Evidence for a new pathophysiological mechanism for coronary artery disease regression: hepatic lipase-mediated changes in LDL density. Circulation1999; 99: 1959-1964.
19. Zambon A, Austin MA, Brown BG, Hokanson JE, Brunzell JD. Effect of hepatic lipase on LDL in normal men and those with coronary artery disease. Arterioscler Thromb 1993; 13: 147-153.
20. Zambon A, Austin MA, Brown BG, Hokanson JE, Brunzell JD. Effects of hepatic lipase on LDL in normal men and those with coronary artery disease. Arterioscler Thromb 1993; 13: 147-153.
21. Johansson J, Carlson LA, Landou C, Hamsten A. High-density lipoproteins and coronary atherosclerosis: a strong inverse relation with the largest particles is confined to normo-triglyceridemic patients. Arterioscler Thromb 1991; 11: 174-182.
22. Herbert PN, Bernier DN, Cullinane EM, Edelstein L, Kantor MA, Thompson PD. High-density lipoprotein metabolism in runners and sedentary men. JAMA 1984; 252: 1034-1037.
23. Elmahgoub SM, Lambers S, Stegen S, Van Laethem C, Cambier D, Calders P. The influence of combined exercise training on indices of obesity, physical fitness and lipid profile in overweight and obese adolescents with mental retardation. Eur J Pediatr 2009; 168: 1327-1333.
24. Greene NP, Martin SE, Crouse SF. Acute exercise and training alter blood lipid and lipoprotein profiles differently in overweight and obese men and women. Obesity (Silver Spring) 2012; 20: 1618-1627.
25. Hojjati Z, Shahsavari S. Acute effects of aerobic and combined exercise on serum lipid profile in type II diabetic females. Iran J Health Sci 2015; 3: 31-37.
26. Chapman MJ, Ginsberg HN, Amarenco P, Andreotti F, Boren J, Catapano AL, et al. Triglyceride-rich lipoproteins and high density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J 2011; 32: 1345-1361.
27. Daly RM, Miller EG, Dunstan DW, Kerr DA, Solah V, Menzies D, et al. The effects of progressive resistance training combined with a whey-protein drink and vitamin D supplementation on glycaemic control, body composition and cardiometabolic risk factors in older adults with type 2 diabetes: study protocol for a randomized controlled trial. Trials 2014; 15: 431-443.
28. MacLaren D, Morton J. Biochemistry for sport and exercise metabolism. 1st ed. London, UK: Wiley, 2011; 185-187.
29. Jensen TE, Richter EA. Regulation of glucose and glycogen metabolism during and after exercise. J Physiol 2012; 590: 1069-1076.